Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| GW3965 hydrochloride | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. |  |
| GW3965 hydrochloride | GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC 50 s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 405911-17-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10627A. |  |
| GW3965 Hydrochloride | GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively. Synonyms: GW3965 Hydrochloride; GW 3965 Hydrochloride; GW-3965 Hydrochloride. Grades: >98%. CAS No. 405911-17-3. Molecular formula: C33H31ClF3NO3.HCl. Mole weight: 618.51. |  |
| GW3965 | GW3965 is a potent, selective LXR agonist for hLXRα and hLXR&beta. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). In Vitro: Recruit the steroid receptor coactivator 1 to human LXRα with EC50 of 125 nM in a cell-free ligand-sensing assay; Potent antagonistic activity against hLXRα and hLXRβ in cell-based assays with EC50 of 190 nM and 30 nM, respectively; In human islets, GW3965 (1 μM) reduces expression of selected pro-inflammatory cytokines including IL-8, monocyte chemotactic protein-1 and tissue factor In Vivo: At a dose of 10 mg/kg upregulates ABCA1 expression 8-fold and raises circulating levels of HDL by 30% with Cmax of 12.7 μg/mL and t1/2 of 2 hours. Uses: A liver x receptor agonist; represses the production of pro-inflammatory cytokines by murine mast cells; in vitro: reduces tissue factor production and inflammatory responses in human islets. Synonyms: GW3965; GW 3965; GW-3965; 2- (3- (3- ( (2-chloro-3- (trifluoromethyl) benzyl) (2, 2-diphenylethyl) amino) propoxy) phenyl) acetic acid hydrochloride. Grades: ≥ 98.0%. CAS No. 405911-09-3. Molecular formula: C33H31ClF3NO3. Mole weight: 582.05. | |
Our database is helping our users find suppliers everyday.
