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| Product | Description | |
|---|---|---|
| GYKI 53655 | GYKI 53655 is a selective AMPA receptor antagonist with anticonvulsant activity. Synonyms: GYKI 53655; GYKI53655; GYKI-53655; 5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide. Grades: 99%. CAS No. 143692-18-6. Molecular formula: C19H20N4O3. Mole weight: 352.39. |  |
| GYKI 53655 hydrochloride | GYKI 53655 hydrochloride is a non-competitive AMPA and kainate receptor antagonist displaying anticonvulsant activity. It also acts as a blocker of GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM) at high concentrations. GYKI 53655 prolongs the survival time after MgCl2- induced global cerebral ischemia. Synonyms: GYKI53655 Hydrochloride; GYKI53655 HCl; GYKI53655; GYKI 53655; GYKI-53655. LY 300168 hydrochloride; LY300168 hydrochloride; LY-300168 hydrochloride; 1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride; 5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 143692-48-2. Molecular formula: C19H20N4O3.HCl. Mole weight: 388.85. | |
| GYKI 53655 hydrochloride | GYKI 53655 (LY300168) hydrochloride is an α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid ( AMPA ) antagonist. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY300168 hydrochloride. CAS No. 143692-48-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103228. |  |
| GYKI 53655 Hydrochloride | A potent negative allosteric modulator selective for AMPA glutamate receptors (IC50 = 6 and 5uM for GluA1 and GluA4, respectively) over kainate receptors (IC50 = 63 and 32uM for GluK3 and GluK2b/GluK3 receptors. Used as neuroprotectant and anticonvulsant, and a valuable tool for the study of AMPA receptor-mediated processes in vivo. Group: Biochemicals. Alternative Names: LY 300168, GYKI-53655 Hydrochloride, AMPA Glutamate Receptor Antagonist, GYKI 53655 Hydrochloride, 1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine Hydrochloride. Grades: Highly Purified. CAS No. 143692-48-2. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| SYM 2206 | SYM 2206 is a potent and noncompetitive AMPA receptor antagonist (IC50 = 2.8 μM) that exhibits anticonvulsant activity in vivo. SYM 2206 acts allosterically at the same regulatory site as GYKI 52466 and 53655 but does not bind to the central diazepine binding site. Synonyms: SYM2206; SYM 2206; SYM-2206; (±)-4-(4-Aminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylenedioxyphthalazine; 8-(4-aminophenyl)-5-methyl-N-propyl-5H-[1,3]dioxolo[4,5-g]phthalazine-6-carboxamide. Grades: ≥99% by HPLC. CAS No. 173952-44-8. Molecular formula: C20H22N4O3. Mole weight: 366.42. | |
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