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| Product | Description | |
|---|---|---|
| H-8 dihydrochloride | >98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| H-8 dihydrochloride | H-8 (dihydrochloride) is a cell-permeable, reversible and ATP-competitive PKA inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 113276-94-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-112465. |  |
| H-8 dihydrochloride | H-8 is a cell-permeable and potent inhibitor of PKA and PKG with Ki values of 1.2 and 0.48 μM, respectively. It also slightly inhibits PKC and MLCK with Ki values of 15 and 68 μM. Synonyms: N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride. Grades: ≥98%. CAS No. 113276-94-1. Molecular formula: C12H15N3O2S·2HCl. Mole weight: 338.3. |  |
| H-8 dihydrochloride | Potent cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Myosin light chain kinase (MLCK) inhibitor. Tool to study protein crystal structure-inhibitor interactions. Group: Biochemicals. Grades: Highly Purified. CAS No. 113276-94-1. Pack Sizes: 10mg, 50mg. Molecular Formula: C12H15N3O2S 2HCl. US Biological Life Sciences. |  Worldwide |
| H-89, Dihydrochloride - CAS 127243-85-0 | A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (Ki = 48 nM). Group: Fluorescence/luminescence spectroscopy. | |
| H-89 dihydrochloride hydrate | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| H-89 dihydrochloride (N-5-isoquinolinesulfonamid e . 2HCl) | Cell permeable potent and selective cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Protein kinase Cµ (PKCµ) inhibitor. Ca2+/calmodulin-dependent protein kinase II inhibitor. Casein kinase I inhibitor. Myosin light chain kinase (MLCK) inhibitor. Apoptosis enhancer. Tool to study protein crystal structure-inhibitor interactions. Rho kinase inhibitor. Cell proliferation inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 127243-85-0. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C20H20BrN3O2S. 2HCl, Molecular Weight: 519.3. US Biological Life Sciences. | Worldwide |
| H-89 Dihydrochloride (PKA Inhibitor III, N- [2- ( (p-Bromocinnamyl ) amino) ethyl ]-5-isoquinolinesulfonamid e , 2HCl) | A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (Ki = 48nM). Inhibits other kinases only at much higher concentrations: CaM kinase II (Ki = 29.7uM), casein kinase I (Ki = 38.3uM), myosin light chain kinase (Ki = 28.3uM), protein kinase C (Ki = 31.7uM), and ROCK-II (IC50 = 270nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs) such as GEFI, GEFII, or Epac (exchange protein directly activated by cAMP). Enhances radiation-induced apoptosis in the human cell line BM 13674. Group: Biochemicals. Grades: Highly Purified. CAS No. 127243-85-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| H-8, Dihydrochloride | A potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases. Group: Fluorescence/luminescence spectroscopy. | |
| InSolution H-89, Dihydrochloride | H-89, Dihydrochloride, CAS 127243-85-0, is a 10 mM solution of H-89, 2HCl in DMSO. A cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 48 nM). Group: Fluorescence/luminescence spectroscopy. | |
| N-[2- (p-Bromocinnamylamino) ethyl]-5-isoquinoline Sulfonamide, Dihydrochloride (H-89) | Selective inhibitor of Protein Kinase A (cyclic AMP-dependeant Protein Kinase) with an inhibitory constant of 0.0048 uM. Group: Biochemicals. Alternative Names: H-89. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Protein Kinase Inhibitor H-8 (PKI) (N- [2-( methyl amino) ethy l ]-5-isoquinolinesulfonamid e dihydrochloride) | Inhibits cyclic-nucleotide-dependent protein kinases. Group: Biochemicals. Alternative Names: N- [2-( methyl amino) ethy l ]-5-isoquinolinesulfonamid e dihydrochloride. Grades: Molecular Biology Grade. CAS No. 84478-11-5. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| N- [2-( methyl amino) ethy l ]-5-isoquinolinesulfonamid e dihydrochloride | N- [2-( methyl amino) ethy l ]-5-isoquinolinesulfonamid e dihydrochloride. Group: Biochemicals. Alternative Names: H-8. Grades: Highly Purified. CAS No. 84478-11-5. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C12H17Cl2N3O2S. US Biological Life Sciences. | Worldwide |
| ALB 109564(a) dihydrochloride | ALB 109564(a) is a Tubulin inhibitor as a semi-synthetic derivative of the vinka alkaloid originated by AMRI. It can bind to tubulin monomers and inhibit microtubule formation, this leads to the disruption of mitotic spindle assembly and arrest of tumor cells in the G2/M phase of the cell cycle. Phase I clinical trials for Solid tumours is on going. Uses: Solid tumours. Synonyms: ALB-109564 dihydrochloride; ALB 109564 dihydrochloride; ALB109564 dihydrochloride; Vincaleukoblastine 12(methylthio) hydrochloride (1:2);(3aR,3a1R,4R,5S,5aR,10bR)-methyl 4-acetoxy-3a-ethyl-9-((3S,5S,7S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-13-(methylthio)-2,4,5,6,7,8,9,10-octahydro-1H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate. Grades: 98%. CAS No. 1300114-12-8. Molecular formula: C47H60N4O9S. Mole weight: 930.00. | |
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