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| Product | Description | |
|---|---|---|
| HA-100 | HA-100 is a potent protein kinase inhibitor, with IC 50 s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG) , cAMP-dependent protein kinase (PKA) , protein kinase C (PKC) and MLC-kinase , respectively. HA-100 also used as a ROCK inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 84468-24-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100984. |  |
| HA-1004 | HA-1004 is a potent inhibitor of PKA and PKG with Ki values of 2.3 and 1.4 μM, respectively. It also inhibits PKC and calcium channel protein. HA-1004 was studied as a relaxant for rabbit aortic strips contracted by various agonists, suggesting its potential use for vasorelaxation. It is also an inhibitor of PKC and MLC. Synonyms: 5-Isoquinolinesulfonamide, N-[2-[(aminoiminomethyl)amino]ethyl]-; N-[2-[(Aminoiminomethyl)amino]ethyl]-5-isoquinolinesulfonamide; HA 1004; HA1004; HT 1004; HT-1004; HT1004; N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide; N-(2-guanidinoethyl)isoquinoline-5-sulfonamide. Grade: ≥95%. CAS No. 91742-10-8. Molecular formula: C12H15N5O2S. Mole weight: 293.34. |  |
| HA-1004 | HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 is an antagonist for calcium , that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 91742-10-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-123468. | |
| HA-1004 dihydrochloride | HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein. Synonyms: 5-Isoquinolinesulfonamide, N-[2-[(aminoiminomethyl)amino]ethyl]-, hydrochloride (1:2); 5-Isoquinolinesulfonamide, N-[2-[(aminoiminomethyl)amino]ethyl]-, dihydrochloride; HA 1004 dihydrochloride; HA1004 dihydrochloride; N-(2-guanidinoethyl)-5-isoquinolinesulfonamide dihydrochloride. Grade: ≥98%. CAS No. 92564-08-4. Molecular formula: C12H15N5O2S.2HCl. Mole weight: 366.27. | |
| HA-1004 monohydrochloride | HA-1004 is a potent inhibitor of PKA and PKG with Ki values of 2.3 and 1.4 μM, respectively. It also inhibits PKC and calcium channel protein. HA-1004 was studied as a relaxant for rabbit aortic strips contracted by various agonists, suggesting its potential use for vasorelaxation. Uses: A novel calcium antagonist and vasodilator with no effect on cardiac function. Synonyms: 5-Isoquinolinesulfonamide, N-[2-[(aminoiminomethyl)amino]ethyl]-, hydrochloride (1:1); 5-Isoquinolinesulfonamide, N-[2-[(aminoiminomethyl)amino]ethyl]-, monohydrochloride; HA 1004 hydrochloride; N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide Hydrochloride; N-[2-[(Aminoiminomethyl)amino]ethyl]-5-isoquinolinesulfonamide Monohydrochloride. Grade: 95%. CAS No. 92564-34-6. Molecular formula: C12H15N5O2S.HCl. Mole weight: 329.81. | |
| HA-100 Dihydrochloride | HA-100 Dihydrochloride. Group: Biochemicals. Alternative Names: AGN-PC-00L2ST, SCHEMBL5176161, 1-(5-ISOQUINOLINESULFONYL)-PIPERAZINE. Grades: Highly Purified. CAS No. 210297-47-5. Pack Sizes: 25mg. Molecular Formula: C13 H15 N3O2, Molecular Weight: 350.3. US Biological Life Sciences. |  Worldwide |
| HA-100 Dihydrochloride | HA-100 is an inhibitor of protein kinases including PKA, PKC, and PKG. HA-100 dihydrochloride was reported to increase human fibroblast reprogramming efficiency in combination with PD0325901, CHIR99021, A83-01 and hLIF. Synonyms: 5-(Piperazine-1-sulfonyl)isoquinoline dihydrochloride. Grade: >98%. CAS No. 210297-47-5. Molecular formula: C13H15N3O2S·2HCl. Mole weight: 350.3. | |
| HA-100 hydrochloride | HA-100 hydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. It exhibits potent inhibition toward protein kinase C and cyclic nucleotide dependent protein kinases. Uses: Exhibited potent inhibition toward protein kinase c and cyclic nucleotide dependent protein kinases. Synonyms: 1-(5-Isoquinolinesulfonyl)piperazine hydrochloride; 5-(piperazin-1-ylsulfonyl)isoquinoline hydrochloride. CAS No. 141543-63-7. Molecular formula: C13H16ClN3O2S. Mole weight: 313.80. | |
| 1- (5-Isoquinolinesulfonyl) piperazine, Dihydrochloride (HA-100) | Exhibited potent inhibition toward protein kinase C and cyclic nucleotide dependent protein kinases. Group: Biochemicals. Alternative Names: HA-100. Grades: Highly Purified. CAS No. 141543-63-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| C-1 | C-1 is a protein kinase inhibitor selecitive for PKG, PKA and PKC (IC50 = 4, 8 and 12 μM, respectively) and is widely used as a ROCK inhibitor. Synonyms: HA 100; HA100; HA-100; 5-Piperazin-1-ylsulfonylisoquinoline; 1-(5-Isoquinolinesulfonyl)piperazine. Grade: ≥99% by HPLC. CAS No. 84468-24-6. Molecular formula: C13H15N3O2S. Mole weight: 277.34. | |
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