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| Product | Description | |
|---|---|---|
| Halopemide | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Halopemide | Halopemide is a potent inhibitor of phospholipase D (PLD), and also a dopamine blocker. It is structurally related to butyrophenones and acts as a psychotropic agent, without parkinsonian side effects. Synonyms: NSC 354856; R34301; N-[2-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-fluorobenzamide. Grades: ≥98%. CAS No. 59831-65-1. Molecular formula: C21H22ClFN4O2. Mole weight: 416.9. |  |
| Fipi | FIPI is a derivative of halopemide which potently inhibits both PLD1 and PLD2 with IC50s of 25 nM and 20 nM, respectively. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 939055-18-2. Molecular formula: C23H24FN5O2. Mole weight: 421.47. Purity: 0.9982. Canonical SMILES: O=C(C(N1)=CC2=C1C=CC(F)=C2)NCCN3CCC(N4C5=CC=CC=C5NC4=O)CC3. Product ID: ACM939055182. Alfa Chemistry ISO 9001:2015 Certified. Categories: FIPIMA. |  |
| FIPI | FIPI, a derivative of halopemide, is a potent and selective phospholipase D (PLD) inhibitor with IC50 values of 20 and 25 nM for PLD2 and PLD1 respectively. It attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. It rapidly blocks in vivo PA production with subnanomolar potency. It has good pharmacokinetic parameters in rats. It did not significantly inhibit p38 or ERK phosphorylation in bone marrow-derived macrophages stimulated with lipopolysaccharide. It prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis. Synonyms: 5-Fluoro-2-Indolyl des-Chlorohalopemide; N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide; 5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-indole-2-carboxamide. Grades: >98 %. CAS No. 939055-18-2. Molecular formula: C23H24FN5O2. Mole weight: 421.47. | |
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