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| Product | Description | |
|---|---|---|
| HC-067047 | HC-067047 is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC 50 values of 48 nM, 133 nM, and 17 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 883031-03-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100208. |  |
| HC-067047 | HC-067047 is a potent and selective TRPV4 antagonist. It has been shown to increase functional bladder capacity and to reduce micturition frequency in wild-type mice and rats with cystitis. HC-067047 also attenuated allodynia in diabetic mice, suggesting its potential application for the treatment of painful diabetic neuropathy (PDN). Synonyms: HC 067047; HC067047; 2-methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamide. Grades: ≥98%. CAS No. 883031-03-6. Molecular formula: C26H28F3N3O2. Mole weight: 471.5. |  |
| TRPV4 Antagonist II, HC-067047 | The TRPV4 Antagonist II, HC-067047 controls the biological activity of TRPV4. Group: Fluorescence/luminescence spectroscopy. |  |
| TRPV4 Antagonist II, HC-067047 (2-Methyl-1- (3-morpholinopropyl) -5-phenyl-N- (3- (trifluoromethyl) phenyl) -1H-pyrrole-3-carboxamide, Transient Receptor Potential Vanilloid-4 Antagonist II, HC067047) | A pyrrolocarboxamide compound that potently antagonizes TRP (transient receptor potential) family cation channel TRPV4 activity (IC50 = 17, 48, and 133nM, respectively, against mouse, human, or rat TRPV4 in whole cell voltage-gated current measurement) in a reversible manner, displaying much reduced potency against human ERG and TRPM8 (IC50 = 368 and 780nM, respectively) and little or no activity toward hKv1.3, hTRPA1, hTRPC5, hTRPV1/2/3/6, mTRPM7, mTRPV2, or rKv1.2. HC-067047 is efficacious (10mg/kg via i.p.) in reducing micturition (urination) frequency and increasing voided urine volume of mice and rats suffering from CPA-induced cystitis in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
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