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HDS 029 HDS 029. Group: Biochemicals. Grades: Purified. CAS No. 881001-19-0. Pack Sizes: 1mg, 10mg. US Biological Life Sciences. USBiological 5
Worldwide
HDS 029 HDS 029 is a potent inhibitor of the ErbB receptor family including EGFR, ErbB2 and ErbB4 (IC50 = 0.3, 0.5 and 1.1 nM for ErbB1 (EGFR), ErbB4 and ErbB2, respectively). HDS 029 inhibits EGF-induced erbB1 autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells (IC50 = 2.5 and 24 nM, respectively). Synonyms: HDS 029; HDS 029; HDS 029; N-(4-[(-3-Chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl-2-butynamide; EGFR/ErbB-2/ErbB-4 Inhibitor. Grades: ≥97% by HPLC. CAS No. 881001-19-0. Molecular formula: C17H11ClFN5O. Mole weight: 355.76. BOC Sciences 10

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