Helioxanthin Suppliers USA
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Product | Description | |
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Helioxanthin Quick inquiry Where to buy Suppliers range | Helioxanthin and its analogues decreased cellular RNA levels of HBV and antigen expression as well as selective inhibition of HBV replication in a cell culture model. Helioxanthin analogue 8-1 exhibited anti-DHBV activity as demonstrated by quantification of viral DNA, RNA, covalently closed circular DNA and protein synthesis. Analogue 8-1 did not affect the stability of cellular macromolecules and did not have a sustained antiviral effect after drug removal. When DHBV replication was induced, virus-harbouring cells were more susceptible to the cytotoxicity of 8-1 than non-induced cells. Synonyms: ACH-126447; ACH 126447; ACH126447; HE-145; HE 145; HE145. Helioxanthin. Grades: >98%. CAS No. 18920-47-3. Molecular formula: C20H12O6. Mole weight: 348.31. | |
Helioxanthin 8-1 Quick inquiry Where to buy Suppliers range | Helioxanthin 8-1 is an analogue of helioxanthin, which exhibites significant in vitro anti-HBV/HCV/HSV-1/HIV activity. It showed the most potent antiHBV activity among those helioxanthin analogues tested. It exhibited moderately potent activity against HIV and effective inhibition on DHBV replication. It would therefore be promising to study helioxanthin analogues that contain a six-membered ring instead of the five-membered ring found in the lactam. Synonyms: Helioxanthin 8 1; Helioxanthin analogue 8-1; Helioxanthin analogue 8 1. Grades: >98%. CAS No. 840529-13-7. Molecular formula: C20H12N2O6. Mole weight: 376.32. | |
Helioxanthin derivative 5-4-2 Quick inquiry Where to buy Suppliers range | Helioxanthin derivative 5-4-2 had potent anti-HBV activities in HepG2.2.15 cells, with the EC50s of 1 and 0.08 microM, respectively. The lamivudine-resistant HBV, L526M/M550V double mutant strain, was also sensitive to helioxanthin and 5-4-2. This class of compounds not only inhibited HBV DNA, but also decreased HBV mRNA and HBV protein expression. The EC50 of HBV DNA inhibition was consistent with the EC50 of HBV 3.5 Kb transcript inhibition, which was 1 and 0.09 microM for helioxanthin and 5-4-2 respectively. Synonyms: Helioxanthin 5-4-2; Helioxanthin 5 4 2. Grades: >98%. CAS No. 203935-39-1. Molecular formula: C20H13NO5. Mole weight: 347.32. |