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| Product | Description | |
|---|---|---|
| Heptelidic acid | Antibiotic. Potent selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GADPH. Anticancer compound. Selectively kills high-glycolytic cancer cells through glucose-dependent active ATP deprivation. Antimalarial. Apoptosis inhibitor. DNA fragmentation and caspase-3 activation inhibitor. Selective and competitive inhibitor of mammalian DNA polymerases beta, lambda and terminal deoxynucleotidyl transferase (TdT) in family X of pols. Source:Isolated from Trichoderma sp. Group: Biochemicals. Grades: Highly Purified. CAS No. 57710-57-3 (74310-84-2 deleted). Pack Sizes: 250ug, 1mg. Molecular Formula: C15H20O5. US Biological Life Sciences. |  Worldwide |
| Heptelidic acid | Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic [1]. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases [2]. Koningic acid (KA) is a specific GAPDH inhibitor with an IC 50 of 90 μM [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Koningic acid. CAS No. 57710-57-3. Pack Sizes: 1 mg. Product ID: HY-120838. |  |
| Heptelidic acid | It is produced by the strain of Gliocladium virens, Chaetomium globosum, Trichoderma viride. It is a sesquiterpenoid antibiotic. It has antibacterial activity against anaerobes, especially has strong effect on fragile bacilli (MIC is 0.4 μg/mL). It has anti-plasmodium (IC80 is 0.01 μg/mL) and antitumor activity. It is also an inhibitor of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) that acts by binding to the cysteine-149 residue. Synonyms: Koningic acid; (+)-Heptelidic Acid; (5aS,6R,9S,9aS)-6-isopropyl-1-oxo-1,5a,6,7,8,9a-hexahydro-3H-spiro[benzo[c]oxepine-9,2'-oxirane]-4-carboxylic acid; Spiro[2-benzoxepin-9(3H),2'-oxirane]-4-carboxylicacid,1,5a,6,7,8,9a-hexahydro-6-(1-methylethyl)-1-oxo-, (2'S,5aS,6R,9aS)-; Avocettin. Grades: ≥95%. CAS No. 57710-57-3. Molecular formula: C15H20O5. Mole weight: 280.32. |  |
| Heptelidic Acid (Koningic acid, Avocettin, FO-4443, BRN 5091359) | A sesquiterpene antibiotic, isolated from Trichoderma sp. A potent and selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GAPDH. Selectively kills high-glycolytic cancer cells through glucose-dependent active ATP deprivation. Selective and competitive inhibitor of mammalian DNA polymerases beta, lambda and terminal deoxynucleotidyl transferase (TdT) in family X of pols. Group: Biochemicals. Grades: Highly Purified. CAS No. 74310-84-2. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
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