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Biricodar, also known as VX-710 or INCEL, is a novel compound that binds directly to P-gp. VX-710 concentrations of 0.5 to 2.5 M are sufficient to fully restore sensitivity of P-gp expressing cells to the cytotoxic action of paclitaxel and other cytotoxic drugs associated with the MDR phenotype. Synonyms: 1,7-dipyridin-3-ylheptan-4-yl (2S)-1-[2-oxo-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate; biricodar; Incel; N-(2-oxo-2-(3,4,5-trimethoxyphenyl)acety)piperidine-2-carboxylic acid 1,7-bis(3-pyridyl)-4-heptyl ester; VX-710; VX 710; VX710; Biricodar; Incel. CAS No. 159997-94-1. Molecular formula: C34H41N3O7. Mole weight: 603.71.
bis(7)-Tacrine
Acetylcholinesterase (AChE) is the primary cholinesterase in the body. It is an enzyme catalyzing the breakdown of acetylcholine and some other choline esters that function as neurotransmitters. Tacrine is an amino acridine compound that inhibits acetylcholinesterase (AChE), which has been proposed as a clinical treatment for Alzheimer's disease. Bis(7)-Tacrine is a tacrine dimer, linked via a 7-carbon alkyl spacer. It inhibits AChE with an IC50 of 0.40 nM, making it more than 1,000 times more potent than tacrine. It is thought to have multiple mechanisms of action including inhibition of AChE, and inihbititon of the amyloid precursor protein/beta-amyloid cascade. It has been shown to inhibit the formation of Aβ1-42 oligomers and reduce the amount of pre-formed Aβ1-42 oligomers. Synonyms: 1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydro-acridine. Grades: ≥98%. CAS No. 224445-12-9. Molecular formula: C33H40N4·2HCl. Mole weight: 565.6.
Heptyl 2-acetamido-2-Deoxy-beta-d-glucopyranoside
Heterocyclic Organic Compound. Alternative Names: HEPTYL 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSIDE;HEPTYL 2-ACETAMIDO-2-DEOXY-SS-D-GLUCOPYRANOSIDE. CAS No. 115414-48-7. Molecular formula: C15H29NO6. Mole weight: 319.39386. Catalog: ACM115414487.
Heptyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside is an extensively studied biomedical compound, aiding in drug discovery endeavors targeting afflictions such as rheumatoid arthritand neurodegenerative disorders. CAS No. 115431-24-8. Molecular formula: C21H35NO9. Mole weight: 445.5.