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| Product | Description | |
|---|---|---|
| Hetrombopag | Hetrombopag is an orally active human thrombopoietin receptor agonist. Hetrombopag protects Cardiomyocyte Survival from Oxidative Stress Damage as an Enhancer of Stem Cells. Hetrombopag specifically stimulated proliferation and/or differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells, with low nanomolar EC50 values through stimulation of STAT, PI3K and ERK signalling pathways. Notably, hetrombopag effectively up-regulated G1 -phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalized progression of the cell cycle, and prevented apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SHR8735; SHR 8735; SHR-8735; Hetrombopag. Product Category: Agonists. Appearance: Solid powder. CAS No. 1257792-41-8. Molecular formula: C25H22N4O5. Mole weight: 458.47. Purity: >98%. IUPACName: (E)-5-(2-hydroxy-3-(2-(3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)phenyl)furan-2-carboxylic acid. Canonical SMILES: O=C(C1=CC=C(C2=CC=CC(N/N=C3C(N(C4=CC=C5CCCCC5=C4)N=C/3C)=O)=C2O)O1)O. Product ID: ACM1257792418. Alfa Chemistry ISO 9001:2015 Certified. |  |
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