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| Product | Description | |
|---|---|---|
| HM-30181 mesylate | HM30181 is a P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency among several MDR1 inhibitors with IC50 value of 0.63nM. HM30181 is currently under Phase I trials. Uses: Enhance the oral bioavailability of p-gp substrate drugs. Synonyms: HM-30181 mesylate; HM 30181 mesylate; HM30181 mesylate; N-(2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide methanesulfonate; 849675-88-3 (HM30181 HCl salt); 49675-66-7 (HM30181 Free base). Grade: 98%. CAS No. 849675-87-2. Molecular formula: C39H40N6O10S. Mole weight: 784.84. |  |
| HM-30181 mesylate monohydrate | HM-30181 mesylate monohydrate is a P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. Synonyms: Encequidar mesylate monohydrate; HM-30181 methanesulfonate monohydrate; HM30181 mesylate monohydrate; 4H-1-Benzopyran-2-carboxamide, N-(2-(2-(4-(2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-, methanesulfonate, hydrate (1:1:1); FM0F74; HM 30181A; N-[2-(2-{4-[2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl]phenyl}-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl]-4-oxo-4H-1-benzopyran-2-carboxamide methanesulfonate hydrate (1:1:1); N-[2-[2-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-4H-1-benzopyran-2-carboxamide methanesulfonate hydrate (1:1:1); TCA.MSA. Grade: ≥95%. CAS No. 2097125-58-9. Molecular formula: C38H36N6O7.CH4O3S.H2O. Mole weight: 802.85. | |
| Encequidar mesylate | Encequidar, also known as HM-30181, is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. Encequidar showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC(50)=35.4nM). Encequidar is currently under clinical trials. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HM30181; HM-30181; HM 30181; HM-30181 mesylate; Encequidar mesylate. Product Category: Inhibitors. Appearance: White solid powder. CAS No. 849675-87-2. Molecular formula: C39H40N6O10S. Mole weight: 784.84. Purity: >98%. IUPACName: N-(2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide methanesulfonate. Canonical SMILES: O=C(NC1=CC(OC)=C(C=C1C2=NN(N=N2)C3=CC=C(C=C3)CCN4CC5=C(CC4)C=C(C(OC)=C5)OC)OC)C6=CC(C7=C(C=CC=C7)O6)=O.OS(=O)(C)=O. Product ID: ACM849675872. Alfa Chemistry ISO 9001:2015 Certified. |  |
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