Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Hne | Hne. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (E)-4-HYDROXYNONENAL;HNE;4-HYDROXY-2-NONENAL;4-HNE;(+/-)-4-HYDROXY-2E-NONENAL;(+/-)-4-HYDROXYNON-2-ENAL;4-HYDROXYNONENAL;4-hydroxy-2-nonena. Appearance: Colorless oil. CAS No. 75899-68-2. Molecular formula: C9H16O2. Mole weight: 156.22. Purity: 98%+. IUPACName: (E)-4-hydroxynon-2-enal. Canonical SMILES: CCCCCC(C=CC=O)O. Density: 0.941 g/cm³. Product ID: ACM75899682. Alfa Chemistry ISO 9001:2015 Certified. |  |
| HNE (4-Hydroxy-2-nonenal) | HNE is a major product of endogenous lipid peroxidation. The w-6-family (linoleic and arachidonic acids) of polyunsaturated fatty acids may produce HNE as a result of free radical attack. HNE is a highly reactive compound and it can react with several functional groups on biological material, particularly sulfydryl groups to form thioester adduct and then hemiacetals. HNE may also react with histidine and lysine residues of proteins to form stable Michael addition-type of adducts. HNE-modified proteins may display an altered biological functions. Antibodies to HNE will help to visualize the HNE-adducts. Group: Biochemicals. Grades: Highly Purified. CAS No. 75899-68-2. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| HNE-DMA | hexane solution, ?85% (GC). Group: Fluorescence/luminescence spectroscopy. |  |
| Ibrutinib Impurity HNEJ | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Grades: ≥95%. Molecular formula: C49H46N12O4. Mole weight: 866.99. |  |
| 4-Hydroxynonenal | 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 4-HNE. CAS No. 75899-68-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-113466. |  |
| 4-Hydroxynonenal | Synonyms: 4-Hydroxy-2-nonenal; 4-HNE; 4-hydroxynon-2-enal; (2E)-4-Hydroxy-2-nonenal. CAS No. 75899-68-2. Molecular formula: C9H16O2. Mole weight: 156.22. | |
| 4-Hydroxynonenal alkyne | 4-Hydroxynonenal alkyne (4-HNE alkyne) is a click chemical reagent containing alkynes. 4-Hydroxynonenal alkyne induces heme oxygenase and cell apoptosis in colon cancer (RKO) cells [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-HNE alkyne. CAS No. 1011268-23-7. Pack Sizes: 100 μg (6.57 mM * 100 μL in Methyl acetate). Product ID: HY-113803. | |
| BAY 677 | BAY 677 is an inactive control for BAY 678 and a human neutrophil elastase (HNE) inhibitor. Synonyms: BAY-677; BAY 677; BAY677; 5-[(4S)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile. Grades: ≥98% by HPLC. CAS No. 2117404-84-7. Molecular formula: C20H15F3N4O2. Mole weight: 400.35. | |
| BAY 678 | BAY 678 is a cell-permeable human neutrophil elastase (HNE) inhibitor (IC50 = 20 nM) that displays around 2000-fold selectivity for NHE over a panel of 21 other serine proteases. Synonyms: BAY 678; BAY678; BAY-678; 5-[(4R)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile. Grades: ≥98% by HPLC. CAS No. 675103-36-3. Molecular formula: C20H15F3N4O2. Mole weight: 400.35. | |
| BAY 85-8501 | This active molecular is a highly selective neutrophil elastase inhibitor.IC50 for HNE is 0.065 nM, LipE is 7.2. BAY 85-8501 was being tested in clinical studies for the treatment of pulmonary diseases. In Feb 2013, Phase-II clinical trials in Bronchiectasis in Spain were on going. In Mar 2013, Phase-II clinical trials in Bronchiectasis in France, Germany and Italy were on going. In Jun 2014, Bayer completed a phase IIa trial in Bronchiectasis in United Kingdom, Spain, France, Germany and Italy. Uses: The treatment of pulmonary diseases. Synonyms: BAY 85-8501; BAY85-8501; BAY-85-8501; BAY 858501; BAY858501; BAY-858501. (S)-4-(4-cyano-2-(methylsulfonyl)phenyl)-3,6-dimethyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidine-5-carbonitrile. Grades: 98%. CAS No. 1161921-82-9. Molecular formula: C22H17F3N4O3S. Mole weight: 474.46. | |
| Desvenlafaxine | Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC 50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: O-Desmethylvenlafaxine. CAS No. 93413-62-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0602. | |
| Desvenlafaxine succinate hydrate | Desvenlafaxine succinate hydrate, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC 50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine succinate hydrate shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: O-Desmethylvenlafaxine succinate hydrate; Desvenlafaxine succinate monohydrate. CAS No. 386750-22-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0602A. | |
| DOV-216,303 Free Base | DOV-216,303 (Free Base) is a potent triple serotonin , norepinephrine , and dopamine reuptake inhibitor, with IC 50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively [1]. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 66504-40-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-18332C. | |
| Freselestat | Freselestat is a high affinity and selective human neutrophil elastase 1 (HNE1) inhibitor (Ki = 12 nM) with >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Freselestat can be used as treatment for neutrophil-predominant inflammatory lung diseases. Synonyms: 2-(5-amino-6-oxo-2-phenylpyrimidin-1-yl)-N-[1-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-3-methyl-1-oxobutan-2-yl]acetamide; ONO6818; ONO 6818; ONO-6818. Grades: 95%. CAS No. 208848-19-5. Molecular formula: C23H28N6O4. Mole weight: 452.51. | |
| GW311616 | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616; GW 311616. Grades: >98%. CAS No. 198062-54-3. Molecular formula: C19H31N3O4S. Mole weight: 397.53. | |
| GW311616 hydrochloride | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616 hydrochloride; GW 311616 hydrochloride; GW311616A. Grades: >98%. CAS No. 197890-44-1. Molecular formula: C19H32ClN3O4S. Mole weight: 433.99. | |
| Lonodelestat | Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF) [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: POL6014. CAS No. 906547-89-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3293. | |
| Meosuc-ala-ala-pro-ala-chloromethylketone | Meosuc-ala-ala-pro-ala-chloromethylketone. Uses: Designed for use in research and industrial production. Additional or Alternative Names: methoxysuccinyl-alanyl-alanyl-prolyl-alaninechloromethylketone;MEOSUC-AAPA-CMK;MEOSUC-ALA-ALA-PRO-ALA-CHLOROMETHYLKETONE;MEOSUC-ALA-ALA-PRO-ALA-CMK;ELASTASE INHIBITOR II;HNE INHIBITOR;MSACK. Product Category: Heterocyclic Organic Compound. CAS No. 111682-13-4. Molecular formula: C20H31ClN4O7. Mole weight: 474.94. Product ID: ACM111682134. Alfa Chemistry ISO 9001:2015 Certified. | |
| Opiorphin | Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC 50 value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 864084-88-8. Pack Sizes: 10 mg; 25 mg; 50 mg. Product ID: HY-W345510. | |
| (R)-BAY-85-8501 | (R)-BAY-85-8501 is the less active Enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent inhibitor of Human Neutrophil Elastase (HNE) , with an IC 50 of 65 pM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2446175-39-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19908B. | |
| Sivelestat | Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki=0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase. Synonyms: EI546; EI 546; EI-546; LY544349; LY 544349; LY-544349; ONO5046; ONO-5046; ONO 5046. Grades: >98%. CAS No. 127373-66-4. Molecular formula: C20H22N2O7S. Mole weight: 434.46. | |
| Sivelestat sodium tetrahydrate | Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki=0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase. Uses: Serine proteinase inhibitors. Synonyms: EI546 sodium tetrahydrate; EI 546 sodium tetrahydrate; EI-546 sodium tetrahydrate; LY544349 sodium tetrahydrate; LY 544349 sodium tetrahydrate; LY-544349 sodium tetrahydrate; ONO5046 sodium tetrahydrate; ONO 5046 sodium tetrahydrate; ONO-5046 sodium tetrahydrate. Grades: >98%. CAS No. 201677-61-4. Molecular formula: C20H29N2NaO11S. Mole weight: 528.51. | |
| Z-Pro-OH | Z-Pro-OH. Uses: Z-pro-oh can be used: as a starting material to prepare aib-pro endothiopeptides of pharmacological importance. to prepare biologically significant fluorophore-labeled peptide tetramers or dimers. as a reactant to synthesize benzoxazole derived human neutrophil elastase (hne) inhibitors. Additional or Alternative Names: Z-L-Proline. Product Category: Amino Acids. CAS No. 1148-11-4. Mole weight: 249.26. Canonical SMILES: OC(=O)[C@@H]1CCCN1C(=O)OCc2ccccc2. ECNumber: 214-557-4. Product ID: ACM1148114. Alfa Chemistry ISO 9001:2015 Certified. Categories: N-Benzyloxycarbonyl-L-proline, Zero-ohm link. | |
Our database is helping our users find suppliers everyday.
