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| Product | Description | |
|---|---|---|
| HQ461 | HQ461 is a Molecular-glue degrader. HQ461 acts by promoting an interaction between CDK12 and DDB1-CUL4-RBX1 E3 ubiquitin ligase, leading to polyubiquitination and degradation of CDK12-interacting protein Cyclin K (CCNK). Degradation of CCNK mediated by HQ461 compromised CDK12 function, leading to reduced phosphorylation of a CDK12 substrate, downregulation of DNA damage response genes, and cell death. Structure-activity relationship analysis of HQ461 revealed the importance of a 5-methylthiazol-2-amine pharmacophore and resulted in an HQ461 derivate with improved potency. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HQ461; HQ-461; HQ 461. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1226443-41-9. Molecular formula: C15H15N5OS2. Mole weight: 345.44. Purity: >98%. IUPACName: 2-(2-((6-methylpyridin-2-yl)amino)thiazol-4-yl)-N-(5-methylthiazol-2-yl)acetamide. Canonical SMILES: CC1C=CC=C(NC2=NC(CC(=O)NC3=NC=C(C)S3)=CS2)N=1. Product ID: ACM1226443419. Alfa Chemistry ISO 9001:2015 Certified. Categories: HQ-6. |  |
| HQ461 | HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1226443-41-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144981. |  |
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