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| Product | Description | |
|---|---|---|
| 13-deoxydaunorubicin hydroxylase | The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius show broad substrate specificity for structures based on an anthracycline aglycone, but have a strong preference for 4-methoxy anthracycline intermediates (13-deoxydaunorubicin and 13-dihydrodaunorubicin) over their 4-hydroxy analogues (13-deoxycarminomycin and 13-dihydrocarminomycin), as well as a preference for substrates hydroxylated at the C-13 rather than the C-14 position. Group: Enzymes. Synonyms: DoxA. Enzyme Commission Number: EC 1.14.13.181. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0780; 13-deoxydaunorubicin hydroxylase; EC 1.14.13.181; DoxA. Cat No: EXWM-0780. |  |
| 1-deoxypentalenic acid 11β-hydroxylase | The enzyme requires Fe(II) and ascorbate. Isolated from the bacterium Streptomyces avermitilis. Part of the pathway for pentalenolactone biosynthesis. Group: Enzymes. Synonyms: ptlH (gene name); sav2991 (gene name); pntH (gene name). Enzyme Commission Number: EC 1.14.11.35. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0653; 1-deoxypentalenic acid 11β-hydroxylase; EC 1.14.11.35; ptlH (gene name); sav2991 (gene name); pntH (gene name). Cat No: EXWM-0653. | |
| 1-hydroxy-2-naphthoate hydroxylase | The enzyme is involved in the catabolic pathway for the degradation of chrysene in some bacteria. Group: Enzymes. Synonyms: 1-hydroxy-2-naphthoic acid hydroxylase. Enzyme Commission Number: EC 1.14.13.135. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0734; 1-hydroxy-2-naphthoate hydroxylase; EC 1.14.13.135; 1-hydroxy-2-naphthoic acid hydroxylase. Cat No: EXWM-0734. | |
| 24-hydroxycholesterol 7α-hydroxylase | A P450 heme-thiolate protein that is found in liver microsomes and in ciliary non-pigmented epithelium. The enzyme is specific for (24S)-cholest-5-ene-3β,24-diol, which is formed mostly in the brain by EC 1.14.14.25, cholesterol 24-hydroxylase. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH-hemoprotein reductase. Group: Enzymes. Synonyms: 24-hydroxycholesterol 7α-monooxygenase; CYP39A1; CYP39A1 oxysterol 7α-hydroxylase. Enzyme Commission Number: EC 1.14.14.26. CAS No. 288309-90-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0923; 24-hydroxycholesterol 7α-hydroxylase; EC 1.14.14.26; 288309-90-0; 24-hydroxycholesterol 7α-monooxygenase; CYP39A1; CYP39A1 oxysterol 7α-hydroxylase. Cat No: EXWM-0923. | |
| 25/26-hydroxycholesterol 7α-hydroxylase | A P-450 (heme-thiolate) protein. Unlike EC 1.14.14.26, 24-hydroxycholesterol 7α-monooxygenase, which is specific for its oxysterol substrate, this enzyme can also metabolize the oxysterols 24,25-epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol, but to a lesser extent. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH-hemoprotein reductase. Group: Enzymes. Synonyms: 25-hydroxycholesterol 7α-monooxygenase; CYP7B1; CYP7B1 oxysterol 7α-hydroxylase; 27-hydroxycholesterol 7-monooxygenase; 27-hydroxycholesterol 7α-hydroxylase; cholest-5-ene-3β,25-diol,NADPH:oxygen oxidoreductase (7α-hydroxylating); 25-hydroxycholesterol 7α-hydroxylase. Enzyme Commission Number: EC 1.14.14.29. CAS No. 149316-80-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0926; 25/26-hydroxycholesterol 7α-hydroxylase; EC 1.14.14.29; 149316-80-3; 25-hydroxycholesterol 7α-monooxygenase; CYP7B1; CYP7B1 oxysterol 7α-hydroxylase; 27-hydroxycholesterol 7-monooxygenase; 27-hydroxycholesterol 7α-hydroxylase; cholest-5-ene-3β,25-diol,NADPH:oxygen oxidoreductase (7α-hydroxylating); 25-hydroxycholesterol 7α-hydroxylase. Cat No: EXWM-0926. | |
| 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase | A heme-thiolate protein (P-450) enzyme involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus. Group: Enzymes. Synonyms: NcsB3. Enzyme Commission Number: EC 1.14.99.49. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1059; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase; EC 1.14.99.49; NcsB3. Cat No: EXWM-1059. | |
| 3-(3-hydroxyphenyl)propanoate hydroxylase | A flavoprotein (FAD). This enzyme participates in a meta-cleavage pathway employed by the bacterium Escherichia coli for the degradation of various phenylpropanoid compounds. Group: Enzymes. Synonyms: mhpA (gene name). Enzyme Commission Number: EC 1.14.13.127. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0727; 3-(3-hydroxyphenyl)propanoate hydroxylase; EC 1.14.13.127; mhpA (gene name). Cat No: EXWM-0727. | |
| 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA 24-hydroxylase | Requires ATP. The reaction in mammals possibly involves dehydrogenation to give a 24(25)-double bond followed by hydration. However, in amphibians such as the Oriental fire-bellied toad (Bombina orientalis), it is probable that the product is formed via direct hydroxylation of the saturated side chain of (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oate and not via hydration of a 24(25) double bond. In microsomes, the free acid is preferred to the coenzyme A ester, whereas in mitochondria, the coenzyme A ester is preferred to the free-acid form of the substrate. Group: Enzymes. Synonyms: trihydroxycoprostanoyl-CoA oxidase; THC-CoA oxidase; THCA-CoA oxidase; 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA oxidase; 3α,. Enzyme Commission Number: EC 1.17.99.3. CAS No. 119799-47-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1103; 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA 24-hydroxylase; EC 1.17.99.3; 119799-47-2; trihydroxycoprostanoyl-CoA oxidase; THC-CoA oxidase; THCA-CoA oxidase; 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA oxidase; 3α,7α,12α-trihydroxy-5β-cholestan-26-oate 24-hydroxylase. Cat No: EXWM-1103. | |
| 3-hydroxyphenylacetate 6-hydroxylase | 3-hydroxyphenylacetate 6-hydroxylase from Flavobacterium sp. is highly specific for 3-hydroxyphenylacetate and uses NADH and NADPH as electron donors with similar efficiency. Group: Enzymes. Synonyms: 3-hydroxyphenylacetate 6-monooxygenase. Enzyme Commission Number: EC 1.14.13.63. CAS No. 114705-01-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0870; 3-hydroxyphenylacetate 6-hydroxylase; EC 1.14.13.63; 114705-01-0; 3-hydroxyphenylacetate 6-monooxygenase. Cat No: EXWM-0870. | |
| (-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase | This cytochrome P450 enzyme, characterized from the plant Sinopodophyllum hexandrum, produces the direct precursor to etoposide, a potent anticancer drug. It can also act on (-)-deoxypodophyllotoxin with lower efficiency. Group: Enzymes. Synonyms: CYP82D61 (gene name). Enzyme Commission Number: EC 1.14.13.214. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0816; (-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase; EC 1.14.13.214; CYP82D61 (gene name). Cat No: EXWM-0816. | |
| 4-hydroxybenzoate 1-hydroxylase | Requires FAD. The enzyme from Candida parapsilosis is specific for 4-hydroxybenzoate derivatives and prefers NADH to NADPH as electron donor. Group: Enzymes. Synonyms: 4-hydroxybenzoate 1-monooxygenase. Enzyme Commission Number: EC 1.14.13.64. CAS No. 134214-78-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0871; 4-hydroxybenzoate 1-hydroxylase; EC 1.14.13.64; 134214-78-1; 4-hydroxybenzoate 1-monooxygenase. Cat No: EXWM-0871. | |
| 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase | The enzyme, characterized from yeast and mammals, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to (4R)-4-hydroxysphinganine during de novo ceramide synthesis. The enzymes from yeast and from mammals contain an N-terminal cytochrome b5 domain that acts as the direct electron donor to the desaturase active site. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.7, dihydroceramide fatty acyl 2-hydroxylase. Group: Enzymes. Synonyms: FA2H (gene name); SCS7 (gene name). Enzyme Commission Number: EC 1.14.18.6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0968; 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase; EC 1.14.18.6; FA2H (gene name); SCS7 (gene name). Cat No: EXWM-0968. | |
| 4'-methoxyisoflavone 2'-hydroxylase | A heme-thiolate protein (P-450). Acts on isoflavones with a 4'-methoxy group, such as formononetin and biochanin A. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. EC 1.14.13.89, isoflavone 2'-hydroxylase, is less specific and acts on other isoflavones as well as 4'-methoxyisoflavones. Group: Enzymes. Synonyms: isoflavone 2'-monooxygenase (ambiguous); isoflavone 2'-hydroxylase (ambiguous). Enzyme Commission Number: EC 1.14.13.53. CAS No. 110183-49-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0860; 4'-methoxyisoflavone 2'-hydroxylase; EC 1.14.13.53; 110183-49-8; isoflavone 2'-monooxygenase (ambiguous); isoflavone 2'-hydroxylase (ambiguous). Cat No: EXWM-0860. | |
| 50S ribosomal protein L16 3-hydroxylase | The enzyme, characterized from the bacterium Escherichia coli, hydroxylates an arginine residue on the 50S ribosomal protein L16, and is involved in regulation of bacterial ribosome assembly. Group: Enzymes. Synonyms: ycfD (gene name). Enzyme Commission Number: EC 1.14.11.47. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0666; 50S ribosomal protein L16 3-hydroxylase; EC 1.14.11.47; ycfD (gene name). Cat No: EXWM-0666. | |
| 5β-cholestane-3α,7α-diol 12α-hydroxylase | A heme-thiolate protein (P-450). This is the key enzyme in the biosynthesis of the bile acid cholic acid (3α,7α,12α-trihydroxy-5β-cholanoic acid). The activity of this enzyme determines the biosynthetic ratio between cholic acid and chenodeoxycholic acid. The enzyme can also hydroxylate the substrate at the 25 and 26 position, but to a lesser extent. Group: Enzymes. Synonyms: 5β-cholestane-3α,7α-diol 12α-monooxygenase; sterol 12α-hydroxylase (ambiguous); CYP8B1; cytochrome P450 8B1. Enzyme Commission Number: EC 1.14.13.96. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0904; 5β-cholestane-3α,7α-diol 12α-hydroxylase; EC 1.14.13.96; 5β-cholestane-3α,7α-diol 12α-monooxygenase; sterol 12α-hydroxylase (ambiguous); CYP8B1; cytochrome P450 8B1. Cat No: EXWM-0904. | |
| 5-methyl-1-naphthoate 3-hydroxylase | The enzyme from the bacterium Streptomyces sahachiroi is involved in the biosynthesis of 3-methoxy-5-methyl-1-naphthoate, a component of of the the antitumor antibiotic azinomycin B. Group: Enzymes. Synonyms: AziB1. Enzyme Commission Number: EC 1.14.13.189. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0788; 5-methyl-1-naphthoate 3-hydroxylase; EC 1.14.13.189; AziB1. Cat No: EXWM-0788. | |
| 6-deoxyerythronolide B hydroxylase | A heme-thiolate protein (P-450). Isolated from the bacterium Saccharopolyspora erythraea. The enzyme is involved in the biosynthesis of the antibiotic erythromycin. Group: Enzymes. Synonyms: DEB hydroxylase; eryF (gene name); P450(eryF); CYP107A1. Enzyme Commission Number: EC 1.14.13.188. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0787; 6-deoxyerythronolide B hydroxylase; EC 1.14.13.188; DEB hydroxylase; eryF (gene name); P450(eryF); CYP107A1. Cat No: EXWM-0787. | |
| 7α-hydroxycholest-4-en-3-one 12α-hydroxylase | A P-450 heme-thiolate protein. Requires EC 1.6.2.4, NADPH-hemoprotein reductase and cytochrome b5 for maximal activity. This enzyme is important in bile acid biosynthesis, being responsible for the balance between the formation of cholic acid and chenodeoxycholic acid. Group: Enzymes. Synonyms: 7α-hydroxy-4-cholesten-3-one 12α-monooxygenase; CYP12; sterol 12α-hydroxylase (ambiguous); HCO 12α-hydroxylase. Enzyme Commission Number: EC 1.14.18.8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0970; 7α-hydroxycholest-4-en-3-one 12α-hydroxylase; EC 1.14.18.8; 7α-hydroxy-4-cholesten-3-one 12α-monooxygenase; CYP12; sterol 12α-hydroxylase (ambiguous); HCO 12α-hydroxylase. Cat No: EXWM-0970. | |
| 7-deoxyloganin 7-hydroxylase | A heme-thiolate protein (P-450). Group: Enzymes. Enzyme Commission Number: EC 1.14.13.74. CAS No. 335305-40-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0881; 7-deoxyloganin 7-hydroxylase; EC 1.14.13.74; 335305-40-3. Cat No: EXWM-0881. | |
| 8-dimethylallylnaringenin 2'-hydroxylase | A membrane-bound cytochrome P-450 heme-thiolate monooxygenase that is associated with the endoplasmic reticulum. This enzyme is specific for sophoraflavanone B as substrate. NADPH cannot be replaced by NADH, FAD or FMN. Along with EC 2.5.1.70 (naringenin 8-dimethylallyltransferase) and EC 2.5.1.71 (leachianone G 2''-dimethylallyltransferase), this enzyme forms part of the sophoraflavanone-G-biosynthesis pathway. Group: Enzymes. Synonyms: 8-DMAN 2'-hydroxylase. Enzyme Commission Number: EC 1.14.13.103. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0702; 8-dimethylallylnaringenin 2'-hydroxylase; EC 1.14.13.103; 8-DMAN 2'-hydroxylase. Cat No: EXWM-0702. | |
| abieta-7,13-dien-18-ol hydroxylase | A heme-thiolate protein (P-450). This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine), and the gene encoding the enzyme has been identified in Pinus taeda (loblolly pine). The recombinant enzyme catalyses the oxidation of multiple diterpene alcohol and aldehydes, including levopimaradienol, isopimara-7,15-dienol, isopimara-7,15-dienal, dehydroabietadienol and dehydroabietadienal. It is not able to oxidize abietadiene. Group: Enzymes. Synonyms: CYP720B1; PtAO; abietadienol hydroxylase (ambiguous). Enzyme Commission Number: EC 1.14.13.109. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0708; abieta-7,13-dien-18-ol hydroxylase; EC 1.14.13.109; CYP720B1; PtAO; abietadienol hydroxylase (ambiguous). Cat No: EXWM-0708. | |
| abieta-7,13-diene hydroxylase | A heme-thiolate protein (P-450). This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine). The enzyme is localized in the microsomal fraction and requires both oxygen and NADPH. Inhibition by carbon monoxide and several substituted N-heterocyclic inhibitors suggests that the enzyme is a cytochrome P-450-dependent monooxygenase. Activity is induced by wounding of the plant tissue. Group: Enzymes. Synonyms: abietadiene hydroxylase (ambiguous). Enzyme Commission Number: EC 1.14.13.108. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0707; abieta-7,13-diene hydroxylase; EC 1.14.13.108; abietadiene hydroxylase (ambiguous). Cat No: EXWM-0707. | |
| (+)-abscisic acid 8'-hydroxylase | A heme-thiolate protein (P-450). Catalyses the first step in the oxidative degradation of abscisic acid and is considered to be the pivotal enzyme in controlling the rate of degradation of this plant hormone. CO inhibits the reaction, but its effects can be reversed by the presence of blue light. The 8'-hydroxyabscisate formed can be converted into (-)-phaseic acid, most probably spontaneously. Other enzymes involved in the abscisic-acid biosynthesis pathway are EC 1.1.1.288 (xanthoxin dehydrogenase), EC 1.2.3.14 (abscisic-aldehyde oxidase) and EC 1.13.11.51 (9-cis-epoxycarotenoid dioxygenase). Group: Enzymes. Synonyms: (+)-ABA 8'-hydroxylase; ABA 8'-hydroxylase. Enzyme Commission Number: EC 1.14.13.93. CAS No. 153190-37-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0902; (+)-abscisic acid 8'-hydroxylase; EC 1.14.13.93; 153190-37-5; (+)-ABA 8'-hydroxylase; ABA 8'-hydroxylase. Cat No: EXWM-0902. | |
| aklavinone 12-hydroxylase | The enzymes from the Gram-positive bacteria Streptomyces peucetius and Streptomyces purpurascens participate in the biosynthesis of daunorubicin, doxorubicin and rhodomycins. The enzyme from Streptomyces purpurascens is an FAD monooxygenase. Group: Enzymes. Synonyms: DnrF; RdmE; aklavinone 11-hydroxylase (incorrect). Enzyme Commission Number: EC 1.14.13.180. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0779; aklavinone 12-hydroxylase; EC 1.14.13.180; DnrF; RdmE; aklavinone 11-hydroxylase (incorrect). Cat No: EXWM-0779. | |
| α-humulene 10-hydroxylase | Requires cytochrome P-450. The recommended numbering of humulene gives 10-hydroxy-α-humulene as the product rather than 8-hydroxy-α-humulene as used by the reference. See Section F: Natural Product Nomenclature. Group: Enzymes. Synonyms: CYP71BA1. Enzyme Commission Number: EC 1.14.13.150. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0750; α-humulene 10-hydroxylase; EC 1.14.13.150; CYP71BA1. Cat No: EXWM-0750. | |
| averantin hydroxylase | A heme-thiolate (P-450) monooxygenase isolated from Aspergillus parasiticus. There is no reaction with (1'R)-averantin. Involved in aflatoxin biosynthesis. Group: Enzymes. Synonyms: AVN hydroxylase; avnA (gene name); (1'S)-averantin,NADPH:O2 oxidoreductase (5'-hydroxylating). Enzyme Commission Number: EC 1.14.13.174. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0772; averantin hydroxylase; EC 1.14.13.174; AVN hydroxylase; avnA (gene name); (1'S)-averantin,NADPH:O2 oxidoreductase (5'-hydroxylating). Cat No: EXWM-0772. | |
| β-amyrin 24-hydroxylase | A heme-thiolate protein (P-450). Group: Enzymes. Synonyms: sophoradiol 24-hydroxylase; CYP93E1. Enzyme Commission Number: EC 1.14.99.43. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1053; β-amyrin 24-hydroxylase; EC 1.14.99.43; sophoradiol 24-hydroxylase; CYP93E1. Cat No: EXWM-1053. | |
| β-carotene 3-hydroxylase | Requires ferredoxin and Fe(II). Also acts on other carotenoids with a β-end group. In some species canthaxanthin is the preferred substrate. Group: Enzymes. Synonyms: β-carotene 3,3'-monooxygenase; CrtZ. Enzyme Commission Number: EC 1.14.13.129. CAS No. 133425-64-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0729; β-carotene 3-hydroxylase; EC 1.14.13.129; 133425-64-6; β-carotene 3,3'-monooxygenase; CrtZ. Cat No: EXWM-0729. | |
| C-19 steroid 1α-hydroxylase | The enzyme, characterized from the bacterium Sorangium cellulosum, is a class I cytochrome P-450, and uses ferredoxin as its electron donor. It was shown to act on several C-19 steroid substrates, including testosterone, androstenedione, testosterone-acetate and 11-oxoandrostenedione. Group: Enzymes. Synonyms: CYP260A1. Enzyme Commission Number: EC 1.14.15.19. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0944; C-19 steroid 1α-hydroxylase; EC 1.14.15.19; CYP260A1. Cat No: EXWM-0944. | |
| (+)-camphor 6-endo-hydroxylase | A cytochrome P-450 monooxygenase from the bacterium Rhodococcus sp. NCIMB 9784. Group: Enzymes. Synonyms: P450camr. Enzyme Commission Number: EC 1.14.15.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0935; (+)-camphor 6-endo-hydroxylase; EC 1.14.15.10; P450camr. Cat No: EXWM-0935. | |
| (+)-camphor 6-exo-hydroxylase | A cytochrome P-450 monooxygenase isolated from Salvia officinalis (sage). Involved in the catabolism of camphor in senescent tissue. Group: Enzymes. Synonyms: (+)-camphor 6-hydroxylase. Enzyme Commission Number: EC 1.14.13.161. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0761; (+)-camphor 6-exo-hydroxylase; EC 1.14.13.161; (+)-camphor 6-hydroxylase. Cat No: EXWM-0761. | |
| cholesterol 24-hydroxylase | A P-450 heme-thiolate protein. The enzyme can also produce 25-hydroxycholesterol. In addition, it can further hydroxylate the product to 24,25-dihydroxycholesterol and 24,27-dihydroxycholesterol. This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood-brain barrier whereas cholesterol cannot. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH-hemoprotein reductase. Group: Enzymes. Synonyms: cholesterol 24-monooxygenase; CYP46; CYP46A1; cholesterol 24S-hydroxylase; cytochrome P450 46A1. Enzyme Commission Number: EC 1.14.14.25. CAS No. 50812-30-1, 213327-78-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0922; cholesterol 24-hydroxylase; EC 1.14.14.25; 50812-30-1, 213327-78-7; cholesterol 24-monooxygenase; CYP46; CYP46A1; cholesterol 24S-hydroxylase; cytochrome P450 46A1. Cat No: EXWM-0922. | |
| Cholesterol 24-hydroxylase-IN-1 | Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active, and highly selective cholesterol 24-hydroxylase (CH24H or CYP46A1) inhibitor ( IC 50 =8.5 nM). Cholesterol 24-hydroxylase-IN-1 can cross blood-brain barrier [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1613480-70-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144309. |  |
| cholesterol 25-hydroxylase | Unlike most other sterol hydroxylases, this enzyme is not a cytochrome P-450. Instead, it uses diiron cofactors to catalyse the hydroxylation of hydrophobic substrates. The diiron cofactor can be either Fe-O-Fe or Fe-OH-Fe and is bound to the enzyme through interactions with clustered histidine or glutamate residues. In cell cultures, this enzyme down-regulates cholesterol synthesis and the processing of sterol regulatory element binding proteins (SREBPs). Group: Enzymes. Synonyms: cholesterol 25-monooxygenase. Enzyme Commission Number: EC 1.14.99.38. CAS No. 60202-07-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1049; cholesterol 25-hydroxylase; EC 1.14.99.38; 60202-07-5; cholesterol 25-monooxygenase. Cat No: EXWM-1049. | |
| Cholesterol-25-Hydroxylase, Human (CH25H) | Cholesterol-25-Hydroxylase (CH25H) is an intronless gene that is involved in cholesterol and lipid metabolism. The encoded protein is a membrane protein and contains clusters of histidine residues essential for catalytic activity. Unlike most other sterol hydroxylases, this enzyme is a member of a small family of enzymes that utilize diiron cofactors to catalyze the hydroxylation of hydrophobic substrates. Group: Molecular Biology. Pack Sizes: 10ug, 50ug, 100ug. US Biological Life Sciences. |  Worldwide |
| Collagen proline hydroxylase inhibitor | Collagen proline hydroxylase inhibitor is a collagen proline hydroxylase inhibitor; useful for antifibroproliferative agents. Synonyms: 1,10-Phenanthroline-3-carboxamide, N-ethyl-7,10-dihydro-8-nitro-7-oxo-N-propyl-. Grades: >98%. CAS No. 223666-07-7. Molecular formula: C18H18N4O4. Mole weight: 354.36. |  |
| Collagen proline hydroxylase inhibitor | Collagen proline hydroxylase inhibitor is a collagen proline hydroxylase inhibitor; useful for antifibroproliferative agents. Uses: Scientific research. Group: Signaling pathways. CAS No. 223666-07-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15183. | |
| Collagen proline hydroxylase inhibitor-1 | Collagen proline hydroxylase inhibitor-1 is an antifibroproliferative agents. Synonyms: 1,10-Phenanthrolin-4(1H)-one, 3-nitro-8-[[4-(phenylmethyl)-1-piperazinyl]carbonyl]-. Grades: >98%. CAS No. 223663-32-9. Molecular formula: C24H21N5O4. Mole weight: 443.45. | |
| dammarenediol 12-hydroxylase | A heme-thiolate protein (P-450). Involved in the biosynthetic pathway of ginsenosides. Isolated from ginseng (Panax ginseng). Group: Enzymes. Synonyms: protopanaxadiol synthase; CYP716A47; dammarenediol-II,NADPH:O2 oxidoreductase (12β-hydroxylating). Enzyme Commission Number: EC 1.14.13.183. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0782; dammarenediol 12-hydroxylase; EC 1.14.13.183; protopanaxadiol synthase; CYP716A47; dammarenediol-II,NADPH:O2 oxidoreductase (12β-hydroxylating). Cat No: EXWM-0782. | |
| deacetoxycephalosporin-C hydroxylase | Requires iron(II). The enzyme can also use 3-exomethylenecephalosporin C as a substrate to form deacetoxycephalosporin C, although more slowly. In Acremonium chrysogenum, the enzyme forms part of a bifunctional protein along with EC 1.14.20.1, deactoxycephalosporin-C synthase. It is a separate enzyme in Streptomyces clavuligerus. Group: Enzymes. Synonyms: deacetylcephalosporin C synthase; 3'-methylcephem hydroxylase; DACS; DAOC hydroxylase; deacetoxycephalosporin C hydroxylase. Enzyme Commission Number: EC 1.14.11.26. CAS No. 69772-89-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0643; deacetoxycephalosporin-C hydroxylase; EC 1.14.11.26; 69772-89-0; deacetylcephalosporin C synthase; 3'-methylcephem hydroxylase; DACS; DAOC hydroxylase; deacetoxycephalosporin C hydroxylase. Cat No: EXWM-0643. | |
| deacetoxyvindoline 4-hydroxylase | Requires Fe2+ and ascorbate. Also acts on 3-hydroxy-16-methoxy-2,3-dihydrotabersonine and to a lesser extent on 16-methoxy-2,3-dihydrotabersonine. Group: Enzymes. Synonyms: desacetoxyvindoline 4-hydroxylase; desacetyoxyvindoline-17-hydroxylase; D17H; desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4β-hydroxylating). Enzyme Commission Number: EC 1.14.11.20. CAS No. 132084-83-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0637; deacetoxyvindoline 4-hydroxylase; EC 1.14.11.20; 132084-83-4; desacetoxyvindoline 4-hydroxylase; desacetyoxyvindoline-17-hydroxylase; D17H; desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4β-hydroxylating). Cat No: EXWM-0637. | |
| deoxysarpagine hydroxylase | A heme-thiolate protein (P-450). Group: Enzymes. Synonyms: DOSH. Enzyme Commission Number: EC 1.14.13.91. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0900; deoxysarpagine hydroxylase; EC 1.14.13.91; DOSH. Cat No: EXWM-0900. | |
| dihydroceramide fatty acyl 2-hydroxylase | The enzyme, characterized from plants, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to sphinganine during de novo ceramide synthesis. The enzyme requires an external cytochrome b5 as the electron donor. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.6, 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase. Group: Enzymes. Synonyms: FAH1 (gene name); FAH2 (gene name); plant sphingolipid fatty acid 2-hydroxylase. Enzyme Commission Number: EC 1.14.18.7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0969; dihydroceramide fatty acyl 2-hydroxylase; EC 1.14.18.7; FAH1 (gene name); FAH2 (gene name); plant sphingolipid fatty acid 2-hydroxylase. Cat No: EXWM-0969. | |
| dihydromonacolin L hydroxylase | A heme-thiolate protein (cytochrome P-450). The dehydration of 3α-hydroxy-3,5-dihydromonacolin L acid is believed to be spontaneous. The enzyme from fungi also catalyses the reaction of EC 1.14.13.198, monacolin L hydroxylase. Group: Enzymes. Synonyms: LovA (ambiguous). Enzyme Commission Number: EC 1.14.13.197. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0797; dihydromonacolin L hydroxylase; EC 1.14.13.197; LovA (ambiguous). Cat No: EXWM-0797. | |
| docosahexaenoic acid ω-hydroxylase | Isolated from human eye tissue. Defects in the enzyme are associated with Bietti crystalline corneoretinal dystrophy. The enzyme also produces some 21-hydroxydocosahexaenoate. Acts in a similar way on icosapentaenoic acid. Group: Enzymes. Synonyms: CYP4F3B; CYP4V2; docosahexaenoate,NADPH:O2 oxidoreductase (22-hydroxydocosahexaenoate forming). Enzyme Commission Number: EC 1.14.13.199. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0799; docosahexaenoic acid ω-hydroxylase; EC 1.14.13.199; CYP4F3B; CYP4V2; docosahexaenoate,NADPH:O2 oxidoreductase (22-hydroxydocosahexaenoate forming). Cat No: EXWM-0799. | |
| enduracididine β-hydroxylase | Fe2+-dependent enzyme. The enzyme is involved in biosynthesis of the nonproteinogenic amino acid β-hydroxyenduracididine, a component of the mannopeptimycins (cyclic glycopeptide antibiotic), produced by Streptomyces hygroscopicus NRRL 30439. Group: Enzymes. Synonyms: MppO; L-enduracididine,2-oxoglutarate:O2 oxidoreductase (3-hydroxylating). Enzyme Commission Number: EC 1.14.11.40. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0659; enduracididine β-hydroxylase; EC 1.14.11.40; MppO; L-enduracididine,2-oxoglutarate:O2 oxidoreductase (3-hydroxylating). Cat No: EXWM-0659. | |
| ent-cassa-12,15-diene 11-hydroxylase | Requires cytochrome P450. A rice, Oryza sativa, enzyme involved in the biosynthesis of the antifungal phytocassanes. Group: Enzymes. Synonyms: ent-cassadiene C11α-hydroxylase; CYP76M7. Enzyme Commission Number: EC 1.14.13.145. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0745; ent-cassa-12,15-diene 11-hydroxylase; EC 1.14.13.145; ent-cassadiene C11α-hydroxylase; CYP76M7. Cat No: EXWM-0745. | |
| ent-isokaurene C2-hydroxylase | This is the initial step in the conversion of ent-isokaurene to the antibacterial oryzalides in rice, Oryza sativa. Group: Enzymes. Synonyms: CYP71Z6. Enzyme Commission Number: EC 1.14.13.143. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0743; ent-isokaurene C2-hydroxylase; EC 1.14.13.143; CYP71Z6. Cat No: EXWM-0743. | |
| ent-sandaracopimaradiene 3-hydroxylase | A heme-thiolate protein (cytochrome P-450). Isolated from Oryza sativa (rice). Participates in the pathway for the biosynthesis of oryzalexins, a group of related phytoalexins produced by rice. Group: Enzymes. Synonyms: CYP701A; OsKOL4. Enzyme Commission Number: EC 1.14.13.191. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0791; ent-sandaracopimaradiene 3-hydroxylase; EC 1.14.13.191; CYP701A; OsKOL4. Cat No: EXWM-0791. | |
| erythromycin 12-hydroxylase | The enzyme is responsible for the C-12 hydroxylation of the macrolactone ring, one of the last steps in erythromycin biosynthesis. It shows 1200-1900-fold preference for erythromycin D over the alternative substrate erythromycin B. Group: Enzymes. Synonyms: EryK. Enzyme Commission Number: EC 1.14.13.154. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0754; erythromycin 12-hydroxylase; EC 1.14.13.154; EryK. Cat No: EXWM-0754. | |
| ethylbenzene hydroxylase | Involved in the anaerobic catabolism of ethylbenzene by denitrifying bacteria. Ethylbenzene is the preferred substrate; the enzyme from some strains oxidizes propylbenzene, 1-ethyl-4-fluorobenzene, 3-methylpent-2-ene and ethylidenecyclohexane. Toluene is not oxidized. p-Benzoquinone or ferrocenium can act as electron acceptor. Contains molybdopterin, [4Fe-4S] clusters and heme b. Group: Enzymes. Synonyms: ethylbenzene dehydrogenase; ethylbenzene:(acceptor) oxidoreductase. Enzyme Commission Number: EC 1.17.99.2. CAS No. 372947-56-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1102; ethylbenzene hydroxylase; EC 1.17.99.2; 372947-56-3; ethylbenzene dehydrogenase; ethylbenzene:(acceptor) oxidoreductase. Cat No: EXWM-1102. | |
| factor-independent urate hydroxylase | This enzyme was previously thought to be a copper protein, but it is now known that the enzymes from soy bean (Glycine max), the mould Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion. The 5-hydroxyisourate formed decomposes spontaneously to form allantoin and CO2, although there is an enzyme-catalysed pathway in which EC 3.5.2.17, hydroxyisourate hydrolase, catalyses the first step. The enzyme is different from EC 1.14.13.113 (FAD-dependent urate hydroxylase). Group: Enzymes. Synonyms: uric acid oxidase; uricase; uricase II; urate oxidase. Enzyme Commission Number: EC 1.7.3.3. CAS No. 9002-12-4. UO. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1626; factor-independent urate hydroxylase; EC 1.7.3.3; 9002-12-4; uric acid oxidase; uricase; uricase II; urate oxidase. Cat No: EXWM-1626. | |
| FAD-dependent urate hydroxylase | A flavoprotein. The reaction is part of the purine catabolic pathway in the bacterium Klebsiella pneumoniae. The enzyme is different from EC 1.7.3.3, factor-independent urate hydroxylase, found in most plants, which produces hydrogen peroxide. The product of the enzyme is a substrate for EC 3.5.2.17, hydroxyisourate hydrolase. Group: Enzymes. Synonyms: HpxO enzyme; FAD-dependent urate oxidase; urate hydroxylase. Enzyme Commission Number: EC 1.14.13.113. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0713; FAD-dependent urate hydroxylase; EC 1.14.13.113; HpxO enzyme; FAD-dependent urate oxidase; urate hydroxylase. Cat No: EXWM-0713. | |
| flavanoid 3',5'-hydroxylase | A heme-thiolate protein (P-450). The 3',5'-dihydroxyflavanone is formed via the 3'-hydroxyflavanone. In Petunia hybrida the enzyme acts on naringenin, eriodictyol, dihydroquercetin (taxifolin) and dihydrokaempferol (aromadendrin). The enzyme catalyses the hydroxylation of 5,7,4'-trihydroxyflavanone (naringenin) at either the 3' position to form eriodictyol or at both the 3' and 5' positions to form 5,7,3',4',5'-pentahydroxyflavanone (dihydrotricetin). The enzyme also catalyses the hydroxylation of 3,5,7,3',4'-pentahydroxyflavanone (taxifolin) at the 5' position, forming ampelopsin. NADH is not a good substitute for NADPH. Group: Enzymes. Synonyms: flavonoid 3',5'-hydroxylase. Enzyme Commission Number: EC 1.14.13.88. CAS No. 94047-23-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0896; flavanoid 3',5'-hydroxylase; EC 1.14.13.88; 94047-23-1; flavonoid 3',5'-hydroxylase. Cat No: EXWM-0896. | |
| geraniol 8-hydroxylase | Requires cytochrome P-450. Also hydroxylates nerol and citronellol, cf. EC 1.14.13.151 linalool 8-monooxygenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the product rather than 10-hydroxygeraniol as used by references 1-3. See prenol nomenclature Pr-1. The cloned enzyme also catalysed, but less efficiently, the 3'-hydroxylation of naringenin (cf. EC 1.14.13.21, flavonoid 3'-monooxygenase). Group: Enzymes. Synonyms: CYP76B6; G10H; CrG10H; SmG10H. Enzyme Commission Number: EC 1.14.13.152. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0752; geraniol 8-hydroxylase; EC 1.14.13.152; CYP76B6; G10H; CrG10H; SmG10H. Cat No: EXWM-0752. | |
| geranylgeraniol 18-hydroxylase | A heme-thiolate protein (P-450). Group: Enzymes. Synonyms: GGOH-18-hydroxylase. Enzyme Commission Number: EC 1.14.13.110. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0710; geranylgeraniol 18-hydroxylase; EC 1.14.13.110; GGOH-18-hydroxylase. Cat No: EXWM-0710. | |
| geranylhydroquinone 3''-hydroxylase | Contains cytochrome P-450. Group: Enzymes. Synonyms: GHQ 3''-hydroxylase. Enzyme Commission Number: EC 1.14.13.116. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0716; geranylhydroquinone 3''-hydroxylase; EC 1.14.13.116; GHQ 3''-hydroxylase. Cat No: EXWM-0716. | |
| germacrene A hydroxylase | A heme-thiolate protein (P-450). This is probably part of the biosynthesis of many sesquiterpenoid lactones. In Lactuca sativa EC 1.14.13.123 is a mutifunctional enzyme with EC 1.1.1.314, germacrene A alcohol dehydrogenase. Group: Enzymes. Enzyme Commission Number: EC 1.14.13.123. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0724; germacrene A hydroxylase; EC 1.14.13.123. Cat No: EXWM-0724. | |
| HIF-PHD Inhibitor II, JNJ-42041935 (HIF Prolyl Hydroxylase Inhibitor II, 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic Acid) | A cell-permeable benzimidazolopyrazole compound that acts as an active-site binding, iron insensitive, 2-oxoglutarate competitive, reversible and potent inhibitor of PHD1, 2 and 3 isozymes (pKi=7.91, 7.29 and 7.65, respectively). Displays >100-fold selectivity over FIH (factor inhibiting hydroxylase; pIC50 ~4) and minimal affinity towards a panel of receptors, enzymes and kinases. Shown to elevate HIF-1a levels in Hep3B cells and stimulate erythropoietin secretion in mice, and reverse inflammation-induced anemia in rats (100uM/kg). Shown to inhibit malate dehydrogenase 2 (MDH2) activity and suppress mitochondrial respiration. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H?ClF?N?O?, Molecular Weight: 346.7. US Biological Life Sciences. | Worldwide |
| isoflavone 2'-hydroxylase | A heme-thiolate protein (P-450). Acts on daidzein, formononetin and genistein. EC 1.14.13.53, 4'-methoxyisoflavone 2'-hydroxylase, has the same reaction but is more specific as it requires a 4'-methoxyisoflavone. Group: Enzymes. Synonyms: isoflavone 2'-monooxygenase; CYP81E1; CYP Ge-3. Enzyme Commission Number: EC 1.14.13.89. CAS No. 110183-49-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0897; isoflavone 2'-hydroxylase; EC 1.14.13.89; 110183-49-8; isoflavone 2'-monooxygenase; CYP81E1; CYP Ge-3. Cat No: EXWM-0897. | |
| isoflavone 3'-hydroxylase | A heme-thiolate protein (P-450). Also acts on biochanin A and other isoflavones with a 4'-methoxy group. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. Group: Enzymes. Synonyms: isoflavone 3'-monooxygenase. Enzyme Commission Number: EC 1.14.13.52. CAS No. 110183-50-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0859; isoflavone 3'-hydroxylase; EC 1.14.13.52; 110183-50-1; isoflavone 3'-monooxygenase. Cat No: EXWM-0859. | |
| KMO Inhibitor I, Ro 61-8048 (Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide, Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048) | A cell-permeable thiazolyl Benzene sulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (Ki=4.8nM; IC50=37nM). Reported to increase the circulating levels of kynurenic acid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available. Group: Biochemicals. Grades: Highly Purified. CAS No. 199666-03-0. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S?, Molecular Weight: 421.5. US Biological Life Sciences. | Worldwide |
| kynurenine 7,8-hydroxylase | This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating). Other names in common use include kynurenic acid hydroxylase, kynurenic hydroxylase, and kynurenate 7,8-hydroxylase. This enzyme participates in tryptophan metabolism. Group: Enzymes. Synonyms: kynurenic acid hydroxylase; kynurenic hydroxylase; kynurenate 7,8-hydroxylase. Enzyme Commission Number: EC 1.14.99.2. CAS No. 9029-63-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1037; kynurenine 7,8-hydroxylase; EC 1.14.99.2; 9029-63-4; kynurenic acid hydroxylase; kynurenic hydroxylase; kynurenate 7,8-hydroxylase. Cat No: EXWM-1037. | |
| L-arginine hydroxylase | Fe2+-dependent enzyme. The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin. It differs from EC 1.14.11.34, 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming), because it does not form guanidine and (S)-1-pyrroline-5-carboxylate from 3-hydroxy-L-arginine. Group: Enzymes. Synonyms: VioC (ambiguous); L-arginine,2-oxoglutarate:O2 oxidoreductase (3-hydroxylating). Enzyme Commission Number: EC 1.14.11.41. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0660; L-arginine hydroxylase; EC 1.14.11.41; VioC (ambiguous); L-arginine,2-oxoglutarate:O2 oxidoreductase (3-hydroxylating). Cat No: EXWM-0660. | |
| (+)-larreatricin hydroxylase | Isolated from the plant Larrea tridentata (creosote bush). The enzyme has a strong preference for the 3' position of (+)-larreatricin. Group: Enzymes. Enzyme Commission Number: EC 1.14.99.47. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1057; (+)-larreatricin hydroxylase; EC 1.14.99.47. Cat No: EXWM-1057. | |
| L-asparagine hydroxylase | Requires Fe2+. The enzyme is only able to hydroxylate free L-asparagine. It is not active toward D-asparagine. The β-hydroxylated asparagine produced is incorporated at position 9 of the calcium-dependent antibiotic (CDA), an 11-residue non-ribosomally synthesized acidic lipopeptide lactone. Group: Enzymes. Synonyms: L-asparagine 3-hydroxylase; AsnO. Enzyme Commission Number: EC 1.14.11.39. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0657; L-asparagine hydroxylase; EC 1.14.11.39; L-asparagine 3-hydroxylase; AsnO. Cat No: EXWM-0657. | |
| L-isoleucine 4-hydroxylase | The enzyme, characterized from the bacterium Bacillus thuringiensis, can also catalyse the hydroxylation of L-leucine, L-norvaline, L-norleucine, and L-allo-isoleucine, as well as the sulfoxidation of L-methionine, L-ethionine, S-methyl-L-cysteine, S-ethyl-L-cysteine, and S-allyl-L-cysteine. Group: Enzymes. Synonyms: ido (gene name). Enzyme Commission Number: EC 1.14.11.45. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0664; L-isoleucine 4-hydroxylase; EC 1.14.11.45; ido (gene name). Cat No: EXWM-0664. | |
| lithocholate 6β-hydroxylase | A heme-thiolate protein (P-450). Expression of the gene for this enzyme is 50-fold higher in male compared to female hamsters. Group: Enzymes. Synonyms: lithocholate 6β-monooxygenase; CYP3A10; 6β-hydroxylase; cytochrome P450 3A10/lithocholic acid 6β-hydroxylase. Enzyme Commission Number: EC 1.14.13.94. CAS No. 9075-83-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0903; lithocholate 6β-hydroxylase; EC 1.14.13.94; 9075-83-6; lithocholate 6β-monooxygenase; CYP3A10; 6β-hydroxylase; cytochrome P450 3A10/lithocholic acid 6β-hydroxylase. Cat No: EXWM-0903. | |
| lupanine 17-hydroxylase (cytochrome c) | The enzyme isolated from Pseudomonas putida contains heme c and requires pyrroloquinoline quinone (PQQ) for activity. Group: Enzymes. Synonyms: lupanine dehydrogenase (cytochrome c). Enzyme Commission Number: EC 1.17.2.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1086; lupanine 17-hydroxylase (cytochrome c); EC 1.17.2.2; lupanine dehydrogenase (cytochrome c). Cat No: EXWM-1086. | |
| methyl-branched lipid ω-hydroxylase | The enzyme, found in pathogenic and nonpathogenic mycobacteria species, actinomycetes, and some proteobacteria, hydroxylates the ω-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. It is a P-450 heme-thiolate enzyme. Group: Enzymes. Synonyms: CYP124. Enzyme Commission Number: EC 1.14.15.14. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0939; methyl-branched lipid ω-hydroxylase; EC 1.14.15.14; CYP124. Cat No: EXWM-0939. | |
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