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| Product | Description | |
|---|---|---|
| 5-Hydroxymethylcytosine | 5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 5hmC. CAS No. 1123-95-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W018324. |  |
| 5-Hydroxymethylcytosine | 5-Hydroxymethylcytosine. Group: Biochemicals. Grades: Highly Purified. CAS No. 1123-95-1. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C5H7N3O2. US Biological Life Sciences. |  Worldwide |
| 5-Hydroxymethylcytidine | 5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base. It is formed from the DNA base cytosine by adding a methyl group and then a hydroxy group. It is important in epigenetics, because the hydroxymethyl group on the cytosine can possibly switch a gene on and off. It was first seen in bacteriophages in 1952.[1][2] However, in 2009 it was found to be abundant in human and mouse brains,[3] as well as in embryonic stem cells.[4] In mammals, it can be generated by oxidation of 5-methylcytosine, a reaction mediated by the Tet family of enzymes. 5-Hydroxymethylcytidine is a product in DNA hydroxymethylation. The concentrations of 5-Hydroxymethylcytidine in the brain were used to study Alzheimers disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 19235-17-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| T4 β-glucosyltransferase, Recombinant | In enzymology, a DNA beta-glucosyltransferase is an enzyme that catalyzes the chemical reaction in which a beta-D-glucosyl residue is transferred from UDP-glucose to an hydroxymethylcytosine residue in DNA. It is analogous to the enzyme DNA alpha-glucosyltransferase. This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. T4-phage beta-glucosyltransferase, also known as udp glucose-dna ?-glucosyltransferase, (genbank accession no. np_049658) amino acids 1-351 (end) with c-terminal his-tag, mw=41.6 kda, expressed in e. coli. Applications: Useful for the differentiation of hydroxymethylcytosine (hmc) from methylcytosine in dna, via glucosylating hmc and protecting hmc from endonuclease cleavage. Group: Enzymes. Synonyms: T4 Beta-glucosyltransferase; DNA beta-glucosyltransferase; T4-HMC-beta-glucosyl transferase; T4-beta-glucosy. Purity: > 83% (SDS-PAGE). β-glucosyltransferase. Mole weight: mol wt 41.6 kDa. Storage: -70°C. Form: aqueous solution, Formulated in 200 mM imidazole and 20% glycerol. Source: E. coli. T4 Beta-glucosyltransferase; DNA beta-glucosyltransferase; T4-HMC-beta-glucosyl transferase; T4-beta-glucosyl transferase; T4 phage beta-glucosyltransferase; UDP glucose-DNA beta-glucosyltransferase; uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase. Cat No: NATE-0773. |  |
| T4 deoxyribonuclease II | Requires Mg2+. This phage T4 enzyme is involved in degradation of host DNA. The enzyme primarily catalyses nicking of the bottom strand of double stranded DNA between the first and second base pair to the right of a top-strand CCGC motif. Double-stranded breaks are produced 5- to 10-fold less frequently. It does not cleave the T4 native DNA, which contains 5-hydroxymethylcytosine instead of cytosine. Group: Enzymes. Synonyms: T4 endonuclease II; EndoII (ambiguous); denA (gene name). Enzyme Commission Number: EC 3.1.21.8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3578; T4 deoxyribonuclease II; EC 3.1.21.8; T4 endonuclease II; EndoII (ambiguous); denA (gene name). Cat No: EXWM-3578. | |
| T4 deoxyribonuclease IV | This phage T4 enzyme is involved in degradation of host DNA. The enzyme does not cleave double-stranded DNA or native T4 DNA, which contains 5-hydroxymethylcytosine instead of cytosine. Group: Enzymes. Synonyms: T4 endonuclease IV; EndoIV (ambiguous); denB (gene name). Enzyme Commission Number: EC 3.1.21.9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3579; T4 deoxyribonuclease IV; EC 3.1.21.9; T4 endonuclease IV; EndoIV (ambiguous); denB (gene name). Cat No: EXWM-3579. | |
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