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| Product | Description | |
|---|---|---|
| hydroxymethylglutaryl-CoA reductase | This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NAD+ oxidoreductase (CoA-acylating). Other names in common use include beta-hydroxy-beta-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and hydroxymethylglutaryl coenzyme A reductase. Group: Enzymes. Synonyms: β-hydroxy-β-methylglutaryl coenzyme A reductase; β-hydroxy-β-methylglutaryl CoA-reductase; 3-hydroxy-3-methylglutaryl coenzyme A reductase; hydroxymethylglutaryl coenzyme A reductase. Enzyme Commission Number: EC 1.1.1.88. CAS No. 37250-24-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0372; hydroxymethylglutaryl-CoA reductase; EC 1.1.1.88; 37250-24-1; β-hydroxy-β-methylglutaryl coenzyme A reductase; β-hydroxy-β-methylglutaryl CoA-reductase; 3-hydroxy-3-methylglutaryl coenzyme A reductase; hydroxymethylglutaryl coenzyme A reductase. Cat No: EXWM-0372. |  |
| hydroxymethylglutaryl-CoA reductase (NADPH) | The enzyme is inactivated by EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} and reactivated by EC 3.1.3.47 {[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase}. Group: Enzymes. Synonyms: hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate); 3-hydroxy-3-methylglutaryl-CoA reductase; β-hydroxy-β-methylglutaryl coenzyme A reductase; hydroxymethylglutaryl CoA reductase (NADPH); S-3-hydroxy-3-methylglutaryl-CoA reductase; NADPH-hydroxymethylglutaryl-CoA reductase; HMGCoA reductase-mevalonate:NA. Enzyme Commission Number: EC 1.1.1.34. CAS No. 9028-35-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0254; hydroxymethylglutaryl-CoA reductase (NADPH); EC 1.1.1.34; 9028-35-7; hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate); 3-hydroxy-3-methylglutaryl-CoA reductase; β-hydroxy-β-methylglutaryl coenzyme A reductase; hydroxymethylglutaryl CoA reductase (NADPH); S-3-hydroxy-3-methylglutaryl-CoA reductase; NADPH-hydroxymethylglutaryl-CoA reductase; HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA); 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); hydroxymethylglutaryl-CoA reductase (NADPH2). Cat No: EXWM-0254. | |
| [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase | The enzyme is activated by AMP. EC 1.1.1.34, hydroxymethylglutaryl-CoA reductase (NADPH) is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. The enzyme can also phosphorylate hepatic acetyl-CoA carboxylase (EC 6.4.1.2) and adipose hormone-sensitive lipase (EC 3.1.1.79). Thr-172 within the catalytic subunit (α-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase. GTP can act instead of ATP. Group: Enzymes. Synonyms: AMPK; AMP-activated protein kinase; HMG-CoA reductase kinase; β-hydro. Enzyme Commission Number: EC 2.7.11.31. CAS No. 172522-01-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3152; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase; EC 2.7.11.31; 172522-01-9; AMPK; AMP-activated protein kinase; HMG-CoA reductase kinase; β-hydroxy-β-methylglutaryl-CoA reductase kinase; [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase; 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase; 3-hydroxy-3-methylglutaryl-CoA reductase kinase; hydroxymethylglutaryl coenzyme A reductase kinase; hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating); hydroxymethylglutaryl-CoA reductase kinase; reductase kinase; STK29. Cat No: EXWM-3152. | |
| [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase | Acts on the product of the reaction catalysed by EC 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase, simultaneously dephosphorylating and activating EC 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH). Group: Enzymes. Synonyms: reductase phosphatase. Enzyme Commission Number: EC 3.1.3.47. CAS No. 73507-97-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3651; [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase; EC 3.1.3.47; 73507-97-8; reductase phosphatase. Cat No: EXWM-3651. | |
| [acetyl-CoA carboxylase]-phosphatase | Simultaneously dephosphorylates and activates EC 6.4.1.2 acetyl-CoA carboxylase. Acts similarly on EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase), EC 2.4.1.1 (phosphorylase), EC 2.4.1.11 [glycogen(starch) synthase], and dephosphorylates phosphoprotamine and 4-nitrophenyl phosphate. Not identical to EC 3.1.3.17 ([phosphorylase] phosphatase ) or EC 3.1.3.43 {[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase}. Group: Enzymes. Enzyme Commission Number: EC 3.1.3.44. CAS No. 77000-10-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3648; [acetyl-CoA carboxylase]-phosphatase; EC 3.1.3.44; 77000-10-3. Cat No: EXWM-3648. | |
| Cerivastatin Sodium Salt | A competitive inhibitor of HMG-CoA reductase. Uses: Hydroxymethylglutaryl-coa reductase inhibitors. Synonyms: (3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic Acid Sodium Salt; Rivastatin, Baycol, Lipobay. Grades: > 95%. CAS No. 143201-11-0. Molecular formula: C26H33FNO5.Na. Mole weight: 458.56 22.99. |  |
| dephospho-[reductase kinase] kinase | The enzyme is activated by AMP and is specific for its substrate. Phosphorylates and activates EC 2.7.11.31, [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase, that has been inactivated by EC 3.1.3.16, protein-serine/threonine phosphatase. Group: Enzymes. Synonyms: AMP-activated kinase; AMP-activated protein kinase kinase; hydroxymethylglutaryl coenzyme A reductase kinase kinase; hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating); reductase kinase; reductase kinase kinase; STK30. Enzyme Commission Number: EC 2.7.11.3. CAS No. 72060-33-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3150; dephospho-[reductase kinase] kinase; EC 2.7.11.3; 72060-33-4; AMP-activated kinase; AMP-activated protein kinase kinase; hydroxymethylglutaryl coenzyme A reductase kinase kinase; hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating); reductase kinase; reductase kinase kinase; STK30. Cat No: EXWM-3150. | |
| Fluvastatin sodium salt | Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM. Uses: Anticholesteremic agents; hydroxymethylglutaryl-coa reductase inhibitors. Synonyms: Canef; Fluindostatin; Lescol XL; Lipaxan; Vastin; XU-62-320; XU62320; XU 62 320. Grades: >98%. CAS No. 93957-55-2. Molecular formula: C24H25FNNaO4. Mole weight: 433.45. | |
| Pitavastatin | Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC 50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects [1] [2] [3] [8]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NK-104. CAS No. 147511-69-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-B0144A. |  |
| Pitavastatin 3-O-Glucuronide | A metabolite of Pitavastatin which is a Hydroxymethylglutaryl-CoA reductase inhibitor. Grades: > 95%. Molecular formula: C31H31FNO10. Mole weight: 596.58. | |
| Pitavastatin Acyl Glucuronide | A metabolite of Pitavastatin which is a Hydroxymethylglutaryl-CoA reductase inhibitor. Synonyms: 1-[(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoate] β-D-Glucopyranuronic Acid. Grades: > 95%. CAS No. 574752-66-2. Molecular formula: C31H32FNO10. Mole weight: 597.6. | |
| Pitavastatin Calcium | Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC 50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin Calcium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects [1] [2] [3] [8]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NK-104 hemicalcium; Pitavastatin hemicalcium. CAS No. 147526-32-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0144. | |
| Pitavastatin Impurity 1 (PP-1) | An impurity of Pitavastatin which is a Hydroxymethylglutaryl-CoA reductase inhibitor. Grades: > 95%. Molecular formula: C25H24FNO4. Mole weight: 421.47. | |
| Pitavastatin Lactone | A metabolite of Pitavastatin which is a member of the blood cholesterol lowering medication class of statins. Uses: Hydroxymethylglutaryl-coa reductase inhibitors. Synonyms: Itavastatin Lactone; (4R,6S,E)-6-[2-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl] vinyl] tetrahydro-4-hydroxypyran-2-one. Grades: > 95%. CAS No. 141750-63-2. Molecular formula: C25H22FNO3. Mole weight: 403.46. | |
| Rosuvastatin | Rosuvastatin, also called as ZD 4522 or Crestor, a synthetic statin, in the phase III HYDRA trial for Hypercholesterolaemia, is a competitive inhibitor of HMG-CoA reductase (IC50= 11 nM). Uses: Hydroxymethylglutaryl-coa reductase inhibitors. Synonyms: 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)-; (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid; (3R, 5S, 6E)-7-[4- (4-Fluorophenyl)-6-isopropyl-2-[methyl (methylsulfonyl)amino]pyrimidin-5-yl]-3, 5-dihydroxy-6-heptenoic acid; (E)- (3R, 5S)-7-[4- (4-Fluorophenyl)-6-isopropyl-2-[ (methylsulfonyl) (methyl)amino]pyrimidin-5-yl]-3, 5-dihydroxyhept-6-enoic acid; AZD 4522; AZD-4522; AZD4522; X-Plended; ZD 4522. Grades: 98%. CAS No. 287714-41-4. Molecular formula: C22H28FN3O6S. Mole weight: 481.54. | |
| S,S-Atorvastatin | . Uses: Anticholesteremic agents; hydroxymethylglutaryl-coa reductase inhibitors. Synonyms: (1betaR,deltaR)-2-(p-Fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoic acid; 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-, (R*,R*)-. CAS No. 110862-48-1. Molecular formula: C33H35FN2O5. Mole weight: 558.65. | |
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