Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Hypothemycin | Antifungal. Cytotoxic against some tumor cell lines, partly attributed to inhibition of Ras-inducible genes. Inhibits proliferation of mouse and human T cells. Modulates production of cytokines during T cell activation. Facilitates the ubiquitinylation process of cyclin D1. Potent and selective threonine/tyrosine-specific kinase, MEK and other protein kinases inhibitor in both in vitro and in vivo studies. Group: Biochemicals. Alternative Names: 3H-Oxireno [k] [2] benzoxacyclotetradecin-5, 11 (2H, 4H) -dione, 1a, 8, 9, 15b-tetrahydro-3, 4, 12-trihydroxy-14-methoxy-9-methyl-, (1aR, 3S, 4S, 6Z, 9S, 15bR) -, NSC354462. Grades: Highly Purified. CAS No. 76958-67-3. Pack Sizes: 250ug, 1mg. Molecular Formula: C??H??O?. US Biological Life Sciences. |  Worldwide |
| Hypothemycin | from Hypomyces trichothecoides, ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Hypothemycin | Hypothemycin, a fungal polyketide, is a multikinase inhibitor with K i s of 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1 , MEK1/MEK2 , FLT-3 , PDGFRβ/PDGFRα , and ERK1/ERK2 , respectively [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 76958-67-3. Pack Sizes: 500 μg; 1 mg. Product ID: HY-107417. |  |
| Hypothemycin | Hypothemycin, a resorcylic acid lactone antibiotic, was identified as active in a screen for inhibitors of T cell activation. It was found to inhibit the proliferation of mouse and human T cells stimulated with anti-CD3 mAb + PMA and of human PBMC stimulated with anti-CD3 mAb alone. This inhibition was partially reversed by exogenous IL-2 indicating that it is not due to non-specific toxicity. Hypothemycin potently suppressed the production of IL-2 (IC50: 9 nM) but affected IL-2-induced proliferation to a lesser extent (IC50: 194 nM). Hypothemycin also inhibited IL-6, IL-10, IFN-gamma and TNF-alpha production. By contrast, it markedly enhanced the production of IL-4, IL-5 and IL-13. These effects were seen both at the mRNA and protein secretion levels. Analysis of the effect of hypothemycin on CD69 induction suggested that it disrupts calcineurin-independent rather than calcineurin-dependent signaling. Furthermore, hypothemycin was able to inhibit the phosphorylation of ERK1/2 induced by PMA treatment of T cells. Therefore, hypothemycin represents an inhibitor of T cell activation with a novel mode of action and unique modulatory activity on cytokine production. Synonyms: Hypothemycin. CAS No. 76958-67-3. Molecular formula: C19H22O8. Mole weight: 378.38. |  |
Our database is helping our users find suppliers everyday.
