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| Product | Description | |
|---|---|---|
| Icaritin | Icaritin (Anhydroicaritin) is a prenylflavonoid derivative from Epimedium brevicornu Maxim. and potently inhibits proliferation of K562 cells ( IC 50 of 8 μM) and primary CML cells ( IC 50 of 13.4 μM for CML-CP and 18 μM for CML-BC). Icaritin can regulate MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings, also enhances osteogenesis [1] [2] [3. Uses: Scientific research. Group: Natural products. Alternative Names: Anhydroicaritin. CAS No. 118525-40-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N0678. |  |
| Icaritin | Icaritin. Group: Biochemicals. Alternative Names: 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one. Grades: Highly Purified. CAS No. 118525-40-9. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C21H20O6. US Biological Life Sciences. |  Worldwide |
| Icaritin | Icaritin is unable to promote proliferation, migration and tube-like structure formation by human umbilical vein endothelial cells (HUVECs) in vitro. Icaritin potently inhibited proliferation of K562 cells (IC50 was 8 μM) and primary CML cells (IC50 was 13.4 μM for CML-CP and 18 μM for CML-BC), induced CML cells apoptosis and promoted the erythroid differentiation of K562 cells with time-dependent manner. Furthermore, Icaritin was able to suppress the growth of primary CD34+ leukemia cells (CML) and Imatinib-resistant cells, and to induce apoptosis. Icaritin strongly inhibited the growth of breast cancer MDA-MB-453 and MCF7 cells. At concentrations of 2-3 μM, icaritin induced cell cycle arrest at the G(2)/M phase accompanied by a down-regulation of the expression levels of the G(2)/M regulatory proteins such as cyclinB, cdc2 and cdc25C. Icaritin at concentrations of 4-5 μM, however, induced apoptotic cell death characterized by the accumulation of the annexin V- and propidium iodide-positive cells, cleavage of poly ADP-ribose polymerase (PARP) and down-regulation of the Bcl-2 expression. In mouse leukemia model, Icaritin could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells as effective as Imatinib without suppression of bone marrow. Icaritin could up-regulate phospho-JNK or phospho-C-Jun and down-regulate phospho-ERK, phospho-P-38, Jak-2, phospho-Stat3 and phospho-Akt expression with dose- or time-dependent manner. Synonyms: Anhydroicaritin; 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one; 3-hydroxy-7-o-beta-glucose-8-prenyl-4''-methoxy Chrysin. Grades: >98%. CAS No. 118525-40-9. Molecular formula: C21H20O6. Mole weight: 368.38. |  |
| Icaritin | Icaritin - Product ID: NST-10-167. Category: Flavonoids. Purity: 98%. Test method: HPLC. CAS No. 118525-40-9. Pack Sizes: 0,05g, 0,1g, 0,25g, 0,5g. Appearance: White Powder. Molecular formula: C21H20O6. Mole weight: 368.38. Storage: +2 +8 °C. |  |
| Icaritin | Phenols. CAS No. 118525-40-9. Molecular formula: C21H20O6. Mole weight: 368.38. Purity: 0.99. Catalog: ACM118525409. |  |
| Icaritin (Anhydroicaritin) | Icaritin (Anhydroicaritin). Group: Biochemicals. Grades: Plant Grade. CAS No. 118525-40-9. Pack Sizes: 20mg. Molecular Formula: C21H20O6, Molecular Weight: 368.38. US Biological Life Sciences. | Worldwide |
| Icaritin Liposome (PEGylated) | Icaritin is a natural flavonoid compound that exhibits anticancer effects on various tumors, including hematologic malignancies such as leukemia, lymphoma, and multiple myeloma. This product is a pre-formulated liposome encapsulating Icaritin. It is only for research purposes. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes. |  |
| Desmethyl Icaritin | A metabolite of Icariin. Icaritin and Desmethylicaritin, two metabolites of Icariin, dramatically inhibit the growth of most malignant cells. They also have significant antiangiogenesis properties, inhibiting or eliminating entirely the development of new malignant cells. Group: Biochemicals. Alternative Names: 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one; 3,4',5,7-Tetrahydroxy-8-(3-methyl-2-butenyl)flavone; 4'-Desmethylicaritin; 8-Prenylkaempferol; De-O-methylanhydroicaritin; Noranhydroicaritin. Grades: Highly Purified. CAS No. 28610-31-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Desmethyl Icaritin Tri-O-methoxymethyl Ether | Protected Icaritin metabolite. Group: Biochemicals. Alternative Names: 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one; 3,4',5,7-Tetrahydroxy-8-(3-methyl-2-butenyl)flavone Tri-O-methoxymethyl Ether; 4'-Desmethylicaritin Tri-O-methoxymethyl Ether; 8-Prenylkaempferol Tri-O-methoxymethyl Ether; De-O-methylanhydroicaritin Tri-O-methoxymethyl Ether; Noranhydroicaritin Tri-O-methoxymethyl Ether. Grades: Highly Purified. CAS No. 143724-76-9. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 5-O-(3-Methyl-2-butenyl) Kaempferol Tri-O-methoxymethyl Ether | Intermediate in the preparation of Icaritin metabolites. Group: Biochemicals. Alternative Names: 3, 7-Bis (methoxymethoxy) -2-[4- (methoxymethoxy) phenyl]-5-[ (3-methyl-2-butenyl) oxy]-4H-1-benzopyran-4-one. Grades: Highly Purified. CAS No. 143724-70-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Kaempferide | Kaempferide is a flavonoid that maintains anti-radical and anti-oxidant capabilities, as well as anti-tumor possibilities. Impurity of Icaritin (I163700). Group: Biochemicals. Alternative Names: 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one, 3,5,7-trihydroxy-4'-methoxy-flavone; 3,5,7-Trihydroxy-4'-methoxyflavone; 4'-Methoxykaempferol; 4'-Methylkaempferol; 4'-O-Methylkaempferol; 5,7-Dihydroxy-4'-methoxyflavonol; Kaempferid; Kaempferol 4'-O-methyl ether; Kaempferol 4'-methyl ether; Kaempherol 4'-O-methyl ether; NSC 407294. Grades: Highly Purified. CAS No. 491-54-3. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| SNG-1153 | SNG-1153 is an estrogen receptor ER-α36 modulator derived from icaritin which is purified from Epimedium Genus. SNG-1153 regulates ER-α36, induces phosphorylation of β-catenin, and down-regulates β-catenin, a crucial component of the WNT pathway. It plays a key role in tumor stem cells. Synonyms: 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-8-(3-methyl-2-buten-1-yl)-2-[4-(trifluoromethyl)phenyl]-; 3,5,7-Trihydroxy-8-(3-methyl-2-buten-1-yl)-2-[4-(trifluoromethyl)phenyl]-4H-1-benzopyran-4-one; Fukelading; SNG 1153; SNG1153. Grades: ≥95%. CAS No. 1446712-19-1. Molecular formula: C21H17F3O5. Mole weight: 406.35. | |
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