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| Product | Description | |
|---|---|---|
| Icilin | ?97% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| Icilin | Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 ( TRPM8 ) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner ( EC 50 =1.4 μM). Icilin is a "super-cooling agent" [1] [2]. Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG-3-5. CAS No. 36945-98-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-11062. |  |
| Icilin | Icilin. Group: Biochemicals. Grades: Purified. CAS No. 36945-98-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Icilin | Icilin is a synthetic CMR1/TRPM8 super agonist in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM) more potently than menthol or low temperatures. Uses: Both heat sensitive (vr1) and cold-sensitive (cmr1 (rat); trpm8 (human)) receptors. Synonyms: AG 3-5; AG3-5; AG-3-5; AG 3-5 cpd; 3,4-Dihydro-3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-(1H)-pyrimidin-2-one;3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone. Grades: ≥98%. CAS No. 36945-98-9. Molecular formula: C16H13N3O4. Mole weight: 311.29. |  |
| AMTB hydrochloride | AMTB hydrochloride is a selective TRPM8 channel blocker. AMTB hydrochloride inhibits icilin-induced TRPM8 channel activation with a pIC 50 of 6.23. AMTB hydrochloride can be used for the research of the overactive bladder and painful bladder syndrome. AMTB hydrochloride is a non-selective inhibitor of voltage-gated sodium channels ( Na V ) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 926023-82-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100345. | |
| M8 B hydrochloride | M8 B hydrochloride is a selective and potent channel blocker of transient receptor potential melastatin 8 (TRPM8). It blocks cold-induced and icilin or methol-induced activation of rat, human, and murine TRPM8 channels. It displays no effect at other TRP channels with IC50 value of > 20 mM. It decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 KO mice. It may be used to induce therapeutic hypothermia, which is an effective treatment in cardiac arrest. Synonyms: N-(2-Aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride; N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride; N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide, monohydrochloride. Grades: ≥99% by HPLC. CAS No. 883976-12-3. Molecular formula: C22H25N2O3SCl. Mole weight: 432.96. | |
| TC-I 2000 | TC-I 2000 is a potent and orally bioactive TRPM8 channel blocker. TC-I 2000 was shown to inhibit icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells (IC50 = 53 nM). Synonyms: TC-I2000; TC I 2000; TCI 2000; TCI2000; N-(4-Fluorophenyl)-3,4-dihydro-1-[4-(trifluoromethyl)phenyl]-2(1H)-isoquinolinecarboxamide; 2(1H)-Isoquinolinecarboxamide, N-(4-fluorophenyl)-3,4-dihydro-1-[4-(trifluoromethyl)phenyl]-; 1-(4-Trifluoromethyl-phenyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid (4-fluoro-phenyl)-amide. Grades: ≥99% by HPLC. CAS No. 1159996-20-9. Molecular formula: C23H18F4N2O. Mole weight: 414.40. | |
| Voacangine | Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 ( EC 50 =8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 ( IC 50 =50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 ( IC 50 =9 μM) and it shows noncompetitive inhibition against icilin ( IC 50 =7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana [1]. Uses: Scientific research. Group: Natural products. CAS No. 510-22-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N7536. | |
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