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| Product | Description | |
|---|---|---|
| Icilin | ?97% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| Icilin | Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 ( TRPM8 ) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner ( EC 50 =1.4 μM). Icilin is a "super-cooling agent" [1] [2]. Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG-3-5. CAS No. 36945-98-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-11062. |  |
| Icilin | Icilin. Group: Biochemicals. Grades: Purified. CAS No. 36945-98-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Icilin | Icilin is a synthetic CMR1/TRPM8 super agonist in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM) more potently than menthol or low temperatures. Uses: Both heat sensitive (vr1) and cold-sensitive (cmr1 (rat); trpm8 (human)) receptors. Synonyms: AG 3-5; AG3-5; AG-3-5; AG 3-5 cpd; 3,4-Dihydro-3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-(1H)-pyrimidin-2-one; 3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone. Grade: ≥98%. CAS No. 36945-98-9. Molecular formula: C16H13N3O4. Mole weight: 311.29. |  |
| AMTB hydrochloride | AMTB hydrochloride is a selective TRPM8 channel blocker. AMTB hydrochloride inhibits icilin-induced TRPM8 channel activation with a pIC 50 of 6.23. AMTB hydrochloride can be used for the research of the overactive bladder and painful bladder syndrome. AMTB hydrochloride is a non-selective inhibitor of voltage-gated sodium channels ( Na V ) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 926023-82-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100345. | |
| Voacangine | Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 ( EC 50 =8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 ( IC 50 =50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 ( IC 50 =9 μM) and it shows noncompetitive inhibition against icilin ( IC 50 =7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana [1]. Uses: Scientific research. Group: Natural products. CAS No. 510-22-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N7536. | |
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