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IEM 1460 IEM 1460, an adamantane derivative, is a selective and voltage-dependent open-channel antagonist of AMPA receptors. It is Ca2+ permeable and lacks GluR2 subunits. So it may be used to discriminat between AMPA receptors of different subunit composition. It selectively blocks fast spiking interneuron but not mediums spiny projection neuron in mouse striatum. It is used as an anticonvulsant in vivo. Synonyms: IEM 1460; IEM1460; IEM-1460; N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromide hydrobromide. Grades: ≥98% by HPLC. CAS No. 121034-89-7. Molecular formula: C19H38N2Br2. Mole weight: 454.33. BOC Sciences 10
IEM 1460 IEM 1460. Group: Biochemicals. Grades: Purified. CAS No. 121034-89-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. USBiological 5
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