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| Product | Description | |
|---|---|---|
| IMR-1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| IMR-1 | IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC 50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 310456-65-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100431. |  |
| IMR-1 | IMR-1 is a small-molecule inhibitor of Mastermind Recruitment-1. IMR-1 inhibits Notch target gene transcription via disrupting recruitment of Mastermind 1 to the Notch transcriptional activation complex on chromatin, thereby suppressing tumor growth. Synonyms: IMR-1; IMR 1; IMR1. Inhibitor of Mastermind Recruitment-1; ethyl 2-[2-methoxy-4-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]acetate. Grades: >98%. CAS No. 310456-65-6. Molecular formula: C15H15NO5S2. Mole weight: 353.407. |  |
| IMR-1A | IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC 50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 331862-41-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100431A. | |
| IMR-1A | IMR-1A is a metabolite of IMR-1, and exhibits similar properties as IMR-1. IMR-1A inhibits Notch target gene transcription via disrupting recruitment of Mastermind 1 to the Notch transcriptional activation complex on chromatin, thereby suppressing tumor growth. Synonyms: IMR-1A; IMR 1A; IMR1A; Inhibitor of Mastermind Recruitment-1 Acid; 2-[2-methoxy-4-[(E)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]acetic acid. CAS No. 331862-41-0. Molecular formula: C13H11NO5S2. Mole weight: 325.353. | |
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