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| Product | Description | |
|---|---|---|
| Inauhzin | Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. Moreover, Inauhzin stabilizes p53 by increasing p53 acetylation and preventing MDM2-mediated ubiquitylation of p53 in cells, though not directly in vitro. Remarkably, Inauhzin inhibits cell proliferation, induces senescence and tumour-specific apoptosis, and represses the growth of xenograft tumours derived from p53-harbouring H460 and HCT116 cells without causing apparent toxicity to normal tissues and the tumour-bearing SCID mice. Synonyms: Inauhzin. Grades: 0.98. CAS No. 309271-94-1. Molecular formula: C25H19N5OS2. Mole weight: 469.58. |  |
| 1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one (Inauhzin) | 1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one (Inauhzin). Group: Biochemicals. Alternative Names: 1-(10H-phenothiazin-10-yl)-2-(5H-1,2,4-triazino[5.6-b]indol-3-ylthio)-1-butanone; Inauhzin; INZ. Grades: Highly Purified. CAS No. 309271-94-1. Pack Sizes: 10mg. Molecular Formula: C25H19N5OS2, Molecular Weight: 469.58. US Biological Life Sciences. |  Worldwide |
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