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| Product | Description | |
|---|---|---|
| Infigratinib | Infigratinib (BGJ-398; NVP-BGJ398) is a potent inhibitor of the FGFR family with IC 50 s of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1 , FGFR2 , FGFR3 , and FGFR4 , respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BGJ-398; NVP-BGJ398. CAS No. 872511-34-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13311. |  |
| Infigratinib phosphate | Infigratinib phosphate (BGJ-398 phosphate; NVP-BGJ398 phosphate) is a potent inhibitor of the FGFR family with IC 50 of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1 , FGFR2 , FGFR3 , and FGFR4 , respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BGJ-398 phosphate; NVP-BGJ398 phosphate. CAS No. 1310746-10-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13311A. | |
| BGJ-398 | BGJ398, also known as NVP-BGJ398, is a pan FGFR kinase inhibitor, and is an orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. BGJ398 selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Synonyms: 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea; NVPBGJ398; NVPBGJ 398; NVPBGJ-398; BGJ398; BGJ-398; BG J398; Infigratinib. Grades: 0.98. CAS No. 872511-34-7. Molecular formula: C26H31Cl2N7O3. Mole weight: 560.48. |  |
| NVP-BGJ398 phosphate | Potent and selective inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively); it showed siginificant antitumor activity in RT112 bladder cancer xenografts models overexpressing wild-type FGFR3. Synonyms: Infigratinib phosphate; BGJ-398 phosphate; NVP-BGJ398 phosphate; NVPBGJ398 phosphate. Grades: >98%. CAS No. 1310746-10-1. Molecular formula: C26H34Cl2N7O7P. Mole weight: 658.47. | |
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