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| Product | Description | |
|---|---|---|
| Inhibitor Library | A unique collection of 5700 inhibitors for research in cell signaling, high throughput screening (HTS) and high content screening (HCS) for new drugs; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Covers various major targets including MAPK, PI3K, JAK, HDAC, VEGFR, CDK, etc. ; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L2000. Categories: Inhibitor Libraries. |  |
| Chemokine Inhibitor Library | A unique collection of 59 chemokines or chemokine receptors targeted compounds for high throughput and high content screening; - Targets include chemokines and their receptors, such as CCR, CXCR, CR, CX3CR, etc. ; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L7600. Categories: Chemokine Inhibitor Libraries. | |
| Covalent Inhibitor Library | A unique collection of 941 covalent Inhibitors and other molecules with common warheads like chloroacetyl?2-Chloropropionyl?Acryloyl?sulfonyl fluoride, alkyne?acrylamide, ketocarbonyl?disulfide bond, etc. - Structurally diverse with some covalent inhibitors approved by the FDA- Detailed compound information with structure, target, IC50, and biological activity description- NMR and HPLC/LCMS validated to ensure high purity. Uses: Scientific use. Product Category: L9410. Categories: Covalent Inhibitor Libraries. | |
| Cytokine Inhibitor Library | A unique collection of 613 compounds targeting cytokine signaling for high throughput screening and high content screening for drug discovery; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and most of them are approved to be marketed; - Targets cover various cytokines including IL, CSF, IFN, TNF, TGF-beta family, growth factors, chemokine family, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L3600. Categories: Cytokine Inhibitor Libraries. | |
| FDA-Approved Kinase Inhibitor Library | A unique collection of 280 kinase inhibitors for specific targeting of kinases, ready for high-throughput screening and high-content screening. - All compounds have undergone preclinical studies and clinical trials, approved for marketing by FDA, EMA, PMDA, etc. , with proven biological activity and safety. - Detailed instructions, compound structures, target information, IC50 values, activity descriptions, etc. - NMR, HPLC/LCMS and other assay techniques to ensure the correct structure and high purity of the product and reduce false positives. Uses: Scientific use. Product Category: L1610. Categories: FDA-Approved Kinase Inhibitor Libraries. | |
| Ion Channel Inhibitor Library | A unique collection of 946 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Targets include potassium channel, calcium channel, sodium channel, Proton pump, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L2300. Categories: Ion Channel Inhibitor Libraries. | |
| Kinase Inhibitor Library | A unique collection of 2230 kinase inhibitors for high throughput screening and high content screening for drug discovery in kinase related diseases; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Targets include MAPK, PI3K, JAK, STAT, CDK, MEK, Insulin/IGF receptors, CaM Kinease II, PKA, JNK, PKC, RAF, EGFR, SAPK, GSK, MLCK, Src-family, IKK, PDGFR, VEGFR, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L1600. Categories: Kinase Inhibitor Libraries. | |
| MAPK Inhibitor Library | A unique collection of 367 compounds targeting MAPK signaling for drug discovery in MAPK related diseases; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Targets include ERK, JNK, MEK, p38, MAPK, Raf, RSK, MNK, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L1400. Categories: MAPK Inhibitor Libraries. | |
| Nuclear Receptor Inhibitors Library | A unique collection of 420 nuclear receptor signaling targeted compounds for high throughput and high content screening; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L1510. Categories: Nuclear Receptor Inhibitors Libraries. | |
| Phosphatase Inhibitor Library | A collection of 80 phosphatase inhibitors with known activity; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L9100. Categories: Phosphatase Inhibitor Libraries. | |
| PPI Inhibitor Library | A unique collection of 260 PPI-related compounds for drug screening; - Targets include PD-1/PD-L1, Bcl-2, BET bromodomain, BRD4 bromodomain, etc. - Detailed compound information with structure, target, and biological activity description; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L9400. Categories: PPI Inhibitor Libraries. | |
| Protease Inhibitor Library | A unique collection of 344 protease and proteasome inhibitors for research in chemical genomics, and drug screening; - Targets include proteasome, DPP-4, Serine protease, cysteine protease, MMP, Aspartic proteinases, etc; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L1100. Categories: Protease Inhibitor Libraries. | |
| Tyrosine Kinase Inhibitor Library | A unique collection of 746 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Targets include c-Kit, c-Met, EGFR, FGFR, SRC, JAK, SYK, Btk, Bcr-Abl, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L2200. Categories: Tyrosine Kinase Inhibitor Libraries. | |
| 1-(3-Chloropropoxy)-4-fluorobenzene | 1-(3-Chloropropoxy)-4-fluorobenzene was used as a reagent in the preparation of a library of hydantoin compds which has used to study Aurora kinase A inhibitory activity. It was also used as an alkylation agent in the preparation of tetracyclic quinoxaline butyrophenones as 5-HT2A and postsynaptic D2 antagonists and inhibitors of serotonin transporter for treatment of neuropsychiatric and neurological disorders. Group: Biochemicals. Grades: Highly Purified. CAS No. 1716-42-3. Pack Sizes: 1g, 5g. Molecular Formula: C9H10ClFO, Molecular Weight: 188.63. US Biological Life Sciences. |  Worldwide |
| (2, 6-Dichlorophenyl) methanamine | (2, 6-Dichlorophenyl) methanamine was one of the reactants used in making a library of highly selective and potent G protein-coupled receptor kinase 2 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 6575-27-5. Pack Sizes: 250mg, 1g. Molecular Formula: C7H7Cl2N, Molecular Weight: 176.04. US Biological Life Sciences. | Worldwide |
| CID-755673 | CID-755673 is a selective protein kinase D (PKD) inhibitor. CID-755673 was identified from the National Institutes of Health small molecule repository library of 196,173 compounds. In cell-based assays, CID755673 blocked phorbol ester-induced endogenous PKD1 activation in LNCaP cells in a concentration-dependent manner. CID755673 inhibited prostate cancer cell proliferation, cell migration, and invasion. In summary, our findings indicate that CID755673 is a potent and selective PKD1 inhibitor with valuable pharmacological and cell biological potential. Synonyms: CID-755673; CID 755673; CID755673. Grades: 0.98. CAS No. 521937-07-5. Molecular formula: C12H11NO3. Mole weight: 217.224. |  |
| Mini Electrophilic Heterocyclic Fragment Library | The theoretical basis of FBDD is to select favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect and manage. In addition, fragments have smaller molecular weights, relatively higher solubility, and easier structural optimization. The potential of over-the-counter medicine is higher. Targeted covalent inhibitors and chemical probes have become part of drug discovery methods. Given the advantages of fragment-based drug discovery, screening electrophilic fragments has become a promising alternative to discover and verify new targets and generate viable chemical starting points, even for targets that are almost difficult to handle. In response to this situation, we designed a small library of heterocyclic electrophilic compounds. General technology for covalent fragment screening ?. Uses: Scientific use. Product Category: L7860. Categories: Mini Electrophilic Heterocyclic Fragment Libraries. | |
| 1-Amino-1-cyclopropanecarboxylic acid | 1-Aminocyclopropane-1-carboxylic Acid is a plant growth regulator and an NMDA agonist acting at the glycine site (1). It is also a useful compound to develop DNA-encoded small molecule libraries for screening enzyme inhibitors (2). Group: Biochemicals. Alternative Names: 1-Aminocyclopropane carboxylic Acid; 1-Amino-1-carboxycyclopropane; 1-Aminocyclopropane-1-carboxylate; 1-Aminocyclopropane carboxylic Acid; ACC; ACPC; NSC 98430; α -Aminocyclopropane carboxylic Acid. Grades: Highly Purified. CAS No. 22059-21-8. Pack Sizes: 5g, 10g, 25g, 50g. Molecular Formula: C?H?NO?, Molecular Weight: 101.1. US Biological Life Sciences. | Worldwide |
| Autophagy Compound Library | A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and high content screening (HCS) for new drugs; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Targets include Autophagy inducers, Autophagy inhibitors, Proteasome, HIF, HDAC, Aurora Kinase, E3 Ligase, mTOR, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L3200. Categories: Autophagy Compounds Libraries. | |
| Mitochondria-Targeted Compound Library | A unique collection of 447 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine; - Targets include mitochondria related targets, such as ATPase, mitochondria-associated hexokinase, Bcl-2, NADP, etc. and inhibitors for the autophagy initiating factor, ULK1, also include other promising mitochondria-targeted compounds such as lonidamine, paclitaxel, etc; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L5300. Categories: Mitochondria-Targeted Compounds Libraries. | |
| Purvalanol A, Free Base, 99+% | Purvalanol A is a cell-permeable, potent, and selective cyclin-dependent kinase (CDK) inhibitor. It inhibited CDK kinases with IC50 values of 4 nM for CDC2/cyclin B, 70 nM for CDK2/cyclin A, 35 nM for CDK2/cyclin E, 75 nM for CDK5/p35, and 850 nM for CDK4/cyclin D1. Gray N.S., et al. “Exploiting chemical libraries, structure and genomics in the search for kinase inhibitors.” Science 281: 533-538 (1998). Group: Biochemicals. Grades: Highly Purified. CAS No. 212844-53-6. Pack Sizes: 25mg, 50mg, 100mg. US Biological Life Sciences. | Worldwide |
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