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| Product | Description | |
|---|---|---|
| Irdabisant | Irdabisant (CEP-26401) is a selective, orally active and blood-brain barrier (BBB) penetrant histamine H3 receptor (H3R) inverse agonist/inverse agonist with K i values of 7.2 nM and 2.0 nM for rat H3R and human H3R, respectively. Irdabisant has relatively low inhibitory activity against hERG current with an IC 50 of 13.8 μM. Irdabisant has cognition-enhancing and wake-promoting activities in the rat social recognition model. Irdabisant can be used to research schizophrenia or cognitive impairment [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CEP-26401. CAS No. 1005402-19-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-109968. |  |
| Irdabisant | Irdabisant is a potent, selective histamine H3 receptor inverse agonist. It displayed potent antagonist and inverse agonist activities in [³?S]guanosine 5'-O-(γ-thio)triphosphate binding assays. It may also have therapeutic utility in treating schizophrenia or be used as adjunctive therapy to approved antipsychotics. Uses: Irdabisant may also have therapeutic utility in treating schizophrenia or be used as adjunctive therapy to approved antipsychotics. Synonyms: CEP-26401; CEP 26401; CEP26401; Irdabisant; 3-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-1H-pyridazin-6-one;CEP-26401;CEP26401;(R)-6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)pyridazin-3(2H)-one. Grades: >98 %. CAS No. 1005402-19-6. Molecular formula: C18H23N3O2. Mole weight: 313.40. |  |
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