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Irinotecan hydrochloride trihydrate ((+)-Irinotecan hydrochloride trihydrate) is a topoisomerase I inhibitor with antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (+)-Irinotecan hydrochloride trihydrate; CPT-11 hydrochloride trihydrate. CAS No. 136572-09-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-16568.
Irinotecan hydrochloride trihydrate
Irinotecan hydrochloride trihydrate ((+)-Irinotecan hydrochloride trihydrate) is a topoisomerase I inhibitor with antitumor activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin hydrochloride trihydrate. Product Category: Inhibitors. CAS No. 136572-09-3. Mole weight: 677.2. Purity: 98%+. Product ID: ACM136572093. Alfa Chemistry ISO 9001:2015 Certified.
The hydrochloride salt of Irinotecan. Irinotecan is a prodrug that can be activated to 7-ethyl-10-hydroxy-camptothecin (SN-38) by the carboxylesterase-converting enzyme. SN-38 inhibits topoisomerase I to suppress DNA replication and promote cell death. Synonyms: CPT-11 HCl Trihydrate; CPT 11 HCl Trihydrate; CPT11 HCl Trihydrate; Irinotecan Hcl Trihydrate; UNII-042LAQ1IIS. Grades: >98%. CAS No. 136572-09-3. Molecular formula: C33H38N4O6.HCl.3H2O. Mole weight: 677.18.
Irinotecan (CPT-11) is a topoisomerase I inhibitor. It is a semisynthetic analog of the natural alkaloid camptothecin and has an active metabolite SN-38 (7-Ethyl-10-hydroxycamptothecin). During the S phase of the cell cycle, camptothecins selectively bind to and stabilize topoisomerase I-DNA complexes, inhibiting religation, causing the accumulation of topoisomerase I-mediated single-strand DNA breaks in the DNA, and producing irreversible double-strand DNA breaks that lead to cell death. Group: Biochemicals. Grades: Highly Purified. CAS No. 136572-09-3. Pack Sizes: 100mg. US Biological Life Sciences.
An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Synonyms: (R)-9-[(1,4'-Bipiperidine)-1'-carbonyloxy]-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1Hpyrano[3',4':6,7]indolizino[1,2-b]quinoline hydrochloride trihydrate; USP Irinotecan Related Compound D. Molecular formula: C33H45ClN4O9. Mole weight: 677.18.