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| Product | Description | |
|---|---|---|
| ISRIB | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| ISRIB | ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 548470-11-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12495A. |  |
| ISRIB | ISRIB is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease. In a present study ISRIB demonstrated to attenuate amyloid b-induced neuronal cell death although the pharmacological mechanisms of this action have not yet been elucidated. Synonyms: 2- (4-chlorophenoxy) -N-[4-[[2- (4-chlorophenoxy) acetyl]amino]cyclohexyl]acetamide 2- (4-chlorophenoxy) -N- (4- (2- (4-chlorophenoxy) acetamido) cyclohexyl) acetamide ISRIB compound trans-ISRIB. CAS No. 1597403-47-8. Molecular formula: C22H24Cl2N2O4. Mole weight: 451.34. |  |
| ISRIB (mix-Isomer) | ISRIB (mix-Isomer), is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease. In a present study ISRIB demonstrated to attenuate amyloid b-induced neuronal cell death although the pharmacological mechanisms of this action have not yet been elucidated. Synonyms: Acetamide, N,?N'-1,?4-cyclohexanediylbis[2?-(4-chlorophenoxy)?- ISRIB compound. CAS No. 548470-11-7. Molecular formula: C22H24Cl2N2O4. Mole weight: 451.34. | |
| trans-ISRIB | trans-ISRIB. Group: Biochemicals. Grades: Purified. CAS No. 1597403-47-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| trans-ISRIB | trans-ISRIB is an Integrated Stress Response Inhibitor. trans-ISRIB inhibits the eIF2α phosphorylation-mediated unfolded protein response following induction of ER stress (IC50 = 5 nM in a cell-reporter assay). ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1597403-47-8. Molecular formula: C22H24Cl2N2O4. Mole weight: 451.34. Purity: >98%. IUPACName: N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide). Canonical SMILES: O=C(N[C@H]1CC[C@H](NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3. Product ID: ACM1597403478. Alfa Chemistry ISO 9001:2015 Certified. |  |
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