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| Product | Description | |
|---|---|---|
| IU1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| IU1 | IU1. Group: Biochemicals. Grades: Purified. CAS No. 314245-33-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| IU1 | IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT. Synonyms: IU 1; IU-1; 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(pyrrolidin-1-yl)ethan-1-one. Grades: >98%. CAS No. 314245-33-5. Molecular formula: C18H21FN2O. Mole weight: 300.37. |  |
| IU1 | IU1 is a special Usp14 inhibitor with an IC 50 of 4-5 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 314245-33-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13817. |  |
| IU1-47 | IU1-47 is a potent and selective inhibitor of the proteasomal deubiquitinating enzyme USP14 (IC50 = 60 nM). IU1-47 has been shown to enhance protein degradation rate in cells using as a reporter the microtubule-associated protein tau. Synonyms: 1-[1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)ethanone. Grades: ≥98% by HPLC. CAS No. 670270-31-2. Molecular formula: C19H23ClN2O. Mole weight: 330.85. | |
| USP14 Inhibitor, IU1 | The USP14 Inhibitor, IU1 controls the biological activity of USP14. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| USP14 Inhibitor, IU1 (1-(1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone, 1-(1-(4-Fluorophenyl)-2,5-dimethylpyrrol-3-yl)-2-pyrrolidin-1-ylethanone, Ubiquitin Specific Protease 14 Inhibitor, DUB Inhibitor IX) | A cell-permeable pyrrolylpyrrolidinyl-ethanone compound that directly targets proteasome-associated DUB (deubiquitinating enzyme) USP14 and acts as a potent, active-site-directed and reversible inhibitor of hUSP14 deubiquitinating catalytic activity (IC50=4.7uM for Ub-AMC hydrolysis) with excellent selectivity over proteasome-free USP14 and 8-other hDUBs including IsoT (IC50=100uM), UCH37, BAP1, UCH-L1, UCH-L3, USP15, USP2 and USP7 (IC50>700uM). Shown to enhance proteolysis in cells and induce degradation of misfolded toxic proteins like tau, TDP-43 and GFAP (glial fibrillary acidic protein) in coexpressed-wtMEFs at 50uM and offer protection against oxidative stress-induced cytotoxicity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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