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| Product | Description | |
|---|---|---|
| IWP 4 | IWP 4. Group: Biochemicals. Grades: Purified. CAS No. 686772-17-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| IWP 4 | IWP 4 is a novel and potent inhibitor of Wnt/β-catenin signaling with IC50 value of 25 nM. It blocks palmitylation, subsquent secretion and activity of Wnt. It induces the differentiation of human pluripotent stem cells into cardiomyocytes. It has minimal effect on Notch and Hedgehog signaling pathways. Synonyms: IWP4; IWP 4; IWP-4; N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide; 2-(3,4,6,7-Tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-ylthio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide. Grades: ≥98% by HPLC. CAS No. 686772-17-8. Molecular formula: C23H20N4O3S3. Mole weight: 496.62. |  |
| IWP-2 (N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide) | Cell-permeable. Acts as an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC50 = 27nM) by inhibition of the O-acyltransferase Porcn. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| 3,5-Dimethoxybenzoic Acid | 3,5-Dimethoxybenzoic Acid. Group: Dendrimer building blocks. CAS No. 1132-21-4. Product ID: 3,5-dimethoxybenzoic acid. Molecular formula: 182.17. Mole weight: C9H10O4. COC1=CC(=CC(=C1)C(=O)O)OC. InChI=1S/C9H10O4/c1-12-7-3-6 (9 (10)11)4-8 (5-7)13-2/h3-5H, 1-2H3, (H, 10, 11). IWPZKOJSYQZABD-UHFFFAOYSA-N. 99%. |  |
| IWP 12 | IWP 12 is a Wnt inhibitor that prevents palmitylation of Wnt proteins by Porcupine (Porcn). It blocks post resection juvenile zebrafish tailfin regeneration and is suitable for in vivo assays. It is a membrane-bound O-acyltransferase (MBOAT) and activates Wnt proteins with IC50 value of 15 nM. It inhibits Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. Synonyms: IWP12; IWP 12; IWP-12; N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]acetamide. Grades: ≥98% by HPLC. CAS No. 688353-45-9. Molecular formula: C18H18N4O2S3. Mole weight: 418.56. | |
| IWP-2 | IWP-2. Group: Biochemicals. Alternative Names: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide. Grades: Highly Purified. CAS No. 686770-61-6. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C22H18N4O2S3. US Biological Life Sciences. | Worldwide |
| IWP-2 | IWP-2 is an inhibitor of Wnt processing and secretion with an IC 50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC 50 of 40 nM for the gatekeeper mutant M82F CK1δ [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 686770-61-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13912. |  |
| IWP-2-V2 | IWP-2 is an inhibitor of Wnt production (IC50 = 27 nM) that inhibits porcupine, a membrane-bound acyltransferase that is essential to the pamitoylation of Wnt ligands. IWP-2-V2 is an IWP-2 derivative with less potency. Synonyms: 2-((3-benzyl-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide. Grades: ≥98%. CAS No. 877618-79-6. Molecular formula: C23H20N4O2S3. Mole weight: 480.6. | |
| IWP-3 (Inhibitor of Wnt Production-3) | IWP-3 (Inhibitor of Wnt Production-3). Group: Biochemicals. Alternative Names: 2-[[3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-N- (6-methyl-2-benzothiazolyl)-acetamide. Grades: Highly Purified. CAS No. 687561-60-0. Pack Sizes: 10mg. Molecular Formula: C22 H17 FN 4O2S3 , Molecular Weight: 484.6. US Biological Life Sciences. | Worldwide |
| IWP-L6 | IWP-L6 is a potent Porcupine inhibitor with EC50 value of 0.5 nM. It also inhibits Wnt/β-catenin pathway. Synonyms: IWP L6; Porcn Inhibitor III; 2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(5-phenylpyridin-2-yl)acetamide. Grades: >98%. CAS No. 1427782-89-5. Molecular formula: C25H20N4O2S2. Mole weight: 472.58. | |
| Porcn Inhibitor II, C59 (Wnt-C59, Wnt Pathway Inhibitor XVI, 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide) | A cell-permeable pyridinylphenyl-acetamide that is much more potent than IWP-2 in inhibiting MBOAT family member Porcupine-mediated Wnt palmitoylation (IC50 = 74 pM in STF reporter assays using Wnt3a-transfected HEK293). Shown to be effective against Porcn of murine and human, but not xenopus, species and potently inhibit the processing of both canonical and non-canonical Wnt subtypes. C59 is demonstrated to be orally active and effectively suppress MMTV-WNT1 tumor expansion in mice (5mg/kg & 10mg/kg p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 1243243-89-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Porcn Inhibitor III, IWP-L6 (IWPL6, Wnt Pathway Inhibitor XIX) | A cell-permeable pyridinyl-phenylacetamide that is reported to be 60-times more potent than IWP-2 in suppressing autonomous Wnt signaling in murine L-Wnt-STF fibroblasts (IC50 = 0.5nM) and 100-times more potent in blocking branching morphogenesis in cultured murine embryonic kidney (complete blockage at 50nM). Also shown to be at least twice as potent as TNKS inhibitor IWR-1 in preventing the regeneration of severed zebrafish tailfin and in inhibiting zebrafish embryo prosterior axis formation (Effective conc = 5uM). Its susceptibility to metabolization by serum carboxylesterase limits its in vivo use in rats and mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 1427782-89-6. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S?. US Biological Life Sciences. | Worldwide |
| Wnt Inhibitor IWP-2 | IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM. Uses: Differentiation. Synonyms: IWP 2, IWP-2, IWP2. Grades: 0.98. CAS No. 686770-61-6. Molecular formula: C22H18N4O2S3. Mole weight: 466.592. | |
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