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| Product | Description | |
|---|---|---|
| IWP L6 | IWP L6. Group: Biochemicals. Grades: Purified. CAS No. 1427782-89-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| IWP L6 | IWP L6 (Porcn Inhibitor III) is a Porcn inhibitor with an EC 50 of 0.5 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Porcn Inhibitor III. CAS No. 1427782-89-5. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-15825. |  |
| IWP-L6 | IWP-L6 is a potent Porcupine inhibitor with EC50 value of 0.5 nM. It also inhibits Wnt/β-catenin pathway. Synonyms: IWP L6; Porcn Inhibitor III; 2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(5-phenylpyridin-2-yl)acetamide. Grades: >98%. CAS No. 1427782-89-5. Molecular formula: C25H20N4O2S2. Mole weight: 472.58. |  |
| Porcn Inhibitor III, IWP-L6 (IWPL6, Wnt Pathway Inhibitor XIX) | A cell-permeable pyridinyl-phenylacetamide that is reported to be 60-times more potent than IWP-2 in suppressing autonomous Wnt signaling in murine L-Wnt-STF fibroblasts (IC50 = 0.5nM) and 100-times more potent in blocking branching morphogenesis in cultured murine embryonic kidney (complete blockage at 50nM). Also shown to be at least twice as potent as TNKS inhibitor IWR-1 in preventing the regeneration of severed zebrafish tailfin and in inhibiting zebrafish embryo prosterior axis formation (Effective conc = 5uM). Its susceptibility to metabolization by serum carboxylesterase limits its in vivo use in rats and mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 1427782-89-6. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S?. US Biological Life Sciences. | Worldwide |
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