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| Product | Description | |
|---|---|---|
| Ixazomib | Ixazomib is a proteasome inhibitor and the biologically active form of MLN9708. Ixazomib exhibits an improved pharmacodynamic profile and antitumor activity compared with bortezomib in both OCI-Ly10 and PHTX22L models. Although both Ixazomib and bortezomib prolonged overall survival, reduced splenomegaly, and attenuated IgG2a levels in the iMyc(Cα)/Bcl-X(L) GEM model, only Ixazomib alleviated osteolytic bone disease in the DP54-Luc model. Synonyms: MLN2238; MLN-2238; MLN 2238; Ixazomib. Trade name: Ninlaro. (R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid. Grades: > 95%. CAS No. 1072833-77-2. Molecular formula: C14H19BCl2N2O4. Mole weight: 361.026. |  |
| Ixazomib | Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC 50 of 3.4 nM ( K i of 0.93 nM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN2238. CAS No. 1072833-77-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10453. |  |
| Ixazomib citrate | Ixazomib citrate (MLN9708) is a selective, orally active, second-generation proteasome inhibitor. Ixazomib citrate can be used for the study of a broad range of human malignancies [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN9708. CAS No. 1239908-20-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10452. | |
| Ixazomib Impurity 1 | Grades: > 95%. CAS No. 1201903-02-7. Molecular formula: C24H33BCl2N2O4. Mole weight: 495.26. | |
| Ixazomib Impurity 1 | Ixazomib Impurity 1. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2,2'-(2-(1-(2,5-dichlorobenzamido)-3-methylbutyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid. Molecular Formula: C18H20BCl2NO8. Mole Weight: 460.07. Catalog: APB02180. |  |
| Ixazomib Impurity 10 | Ixazomib Impurity 10. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2,5-dichloro-N-(2-(3-methylbutanamido)-2-oxoethyl)benzamide. Molecular Formula: C14H16Cl2N2O3. Mole Weight: 331.19. Catalog: APB02175. | |
| Ixazomib Impurity 11 | Ixazomib Impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 69125-10-6. Molecular Formula: C3H2ClN3O2. Mole Weight: 147.52. Catalog: APB69125106. | |
| Ixazomib Impurity 12 | Ixazomib Impurity 12. Uses: For analytical and research use. Group: Impurity standards. CAS No. 16290-26-9. Molecular Formula: C7H10BrNO2. Mole Weight: 220.07. Catalog: APB16290269. | |
| Ixazomib Impurity 13 | Ixazomib Impurity 13. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2,5-dichloro-N-(2-(3-hydroxy-3-methylbutanamido)-2-oxoethyl)benzamide. Molecular Formula: C14H16Cl2N2O4. Mole Weight: 347.19. Catalog: APB02062. | |
| Ixazomib Impurity 13 | Ixazomib Impurity 13. Uses: For analytical and research use. Group: Impurity standards. CAS No. 6334-18-5. Molecular Formula: C7H4Cl2O. Mole Weight: 175.01. Catalog: APB6334185. | |
| Ixazomib Impurity 14 | Ixazomib Impurity 14. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2,5-dichloro-N-(2-formamido-2-oxoethyl)benzamide. Molecular Formula: C10H8Cl2N2O3. Mole Weight: 275.09. Catalog: APB02174. | |
| Ixazomib Impurity 14 | Ixazomib Impurity 14. Uses: For analytical and research use. Group: Impurity standards. CAS No. 6287-38-3. Molecular Formula: C7H4Cl2O. Mole Weight: 175.01. Catalog: APB6287383. | |
| Ixazomib Impurity 15 | Ixazomib Impurity 15. Uses: For analytical and research use. Group: Impurity standards. CAS No. 10203-08-4. Molecular Formula: C7H4Cl2O. Mole Weight: 175.01. Catalog: APB10203084. | |
| Ixazomib Impurity 16 | Ixazomib Impurity 16. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl 2-(2,5-dichlorobenzamido)acetate. CAS No. 338965-44-9. Molecular Formula: C10H9Cl2NO3. Mole Weight: 262.09. Catalog: APB338965449. | |
| Ixazomib Impurity 17 | Ixazomib Impurity 17. Uses: For analytical and research use. Group: Impurity standards. CAS No. 349086-08-4. Molecular Formula: C12H15Cl2NO. Mole Weight: 260.16. Catalog: APB349086084. | |
| Ixazomib Impurity 18 | Ixazomib Impurity 18. Uses: For analytical and research use. Group: Impurity standards. CAS No. 328283-61-0. Molecular Formula: C11H11Cl2NO3. Mole Weight: 276.12. Catalog: APB328283610. | |
| Ixazomib Impurity 19 | Ixazomib Impurity 19. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1239908-20-3. Molecular Formula: C20H23BCl2N2O9. Mole Weight: 517.12. Catalog: APB1239908203. | |
| Ixazomib Impurity 2 | Grades: > 95%. Molecular formula: C24H33BCl2N2O4. Mole weight: 495.26. | |
| Ixazomib Impurity 2 | Ixazomib Impurity 2. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(2-amino-2-oxoethyl)-2,5-dichlorobenzamide. CAS No. 1378314-08-9. Molecular Formula: C9H8Cl2N2O2. Mole Weight: 247.08. Catalog: APB1378314089. | |
| Ixazomib Impurity 20 | Ixazomib Impurity 20. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1429055-05-9. Molecular Formula: C14H16Cl2N2O2. Mole Weight: 315.19. Catalog: APB1429055059. | |
| Ixazomib Impurity 21 | Ixazomib Impurity 21. Uses: For analytical and research use. Group: Impurity standards. CAS No. 54730-36-8. Molecular Formula: C7H3Cl5. Mole Weight: 264.35. Catalog: APB54730368. | |
| Ixazomib Impurity 22 | Ixazomib Impurity 22. Uses: For analytical and research use. Group: Impurity standards. CAS No. 10541-71-6. Molecular Formula: C7H3Cl5. Mole Weight: 264.35. Catalog: APB10541716. | |
| Ixazomib Impurity 23 | Ixazomib Impurity 23. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C14H16Cl2N2O2. Mole Weight: 315.19. Catalog: APB10563. | |
| Ixazomib Impurity 24 | Ixazomib Impurity 24. Uses: For analytical and research use. Group: Impurity standards. CAS No. 50-82-8. Molecular Formula: C7H3Cl3O2. Mole Weight: 225.45. Catalog: APB50828. | |
| Ixazomib Impurity 25 | Ixazomib Impurity 25. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C14H8Cl4N2O4S. Mole Weight: 442.09. Catalog: APB10564. | |
| Ixazomib Impurity 26 | Ixazomib Impurity 26. Uses: For analytical and research use. Group: Impurity standards. CAS No. 6660-65-7. Molecular Formula: C8H4Cl2O4. Mole Weight: 235.02. Catalog: APB6660657. | |
| Ixazomib Impurity 27 | Ixazomib Impurity 27. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R) - (3-methyl-1- (2- (2, 3, 5-trichlorobenzamido) acetamido) butyl) boronic acid. Molecular Formula: C14H18BCl3N2O4. Mole Weight: 395.47. Catalog: APB02173. | |
| Ixazomib Impurity 28 | Ixazomib Impurity 28. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C20H23BCl2N2O9. Mole Weight: 517.12. Catalog: APB10565. | |
| Ixazomib Impurity 29 | Ixazomib Impurity 29. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(2,3,5-trichlorobenzamido)acetic acid. Molecular Formula: C9H6Cl3NO3. Mole Weight: 282.51. Catalog: APB02172. | |
| Ixazomib Impurity 3 | Ixazomib Impurity 3. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(2-(2,5-dichlorobenzamido)acetamido)acetic acid. Molecular Formula: C11H10Cl2N2O4. Mole Weight: 305.11. Catalog: APB02178. | |
| Ixazomib Impurity 30 | Ixazomib Impurity 30. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2,2'-(2-(3-methyl-1-(2,3,5-trichlorobenzamido)butyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid. Molecular Formula: C18H19BCl3NO8. Mole Weight: 494.52. Catalog: APB02171. | |
| Ixazomib Impurity 31 | Ixazomib Impurity 31. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R) - (3-methyl-1- (2- (2, 4, 5-trichlorobenzamido) acetamido) butyl) boronic acid. Molecular Formula: C14H18BCl3N2O4. Mole Weight: 395.47. Catalog: APB02169. | |
| Ixazomib Impurity 32 | Ixazomib Impurity 32. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2,2'-(2-(3-methyl-1-(2-(2,4,5-trichlorobenzamido)acetamido)butyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid. Molecular Formula: C20H22BCl3N2O9. Mole Weight: 551.57. Catalog: APB02170. | |
| Ixazomib Impurity 33 | Ixazomib Impurity 33. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(2,4,5-trichlorobenzamido)acetic acid. Molecular Formula: C9H6Cl3NO3. Mole Weight: 282.51. Catalog: APB02166. | |
| Ixazomib Impurity 34 | Ixazomib Impurity 34. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2,2'-(2-(3-methyl-1-(2,4,5-trichlorobenzamido)butyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid. Molecular Formula: C18H19BCl3NO8. Mole Weight: 494.52. Catalog: APB02168. | |
| Ixazomib Impurity 39 | Ixazomib Impurity 39. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2,5-dichloro-N-(2-(isopentylamino)-2-oxoethyl)benzamide. Molecular Formula: C14H18Cl2N2O2. Mole Weight: 317.21. Catalog: APB02167. | |
| Ixazomib Impurity 4 | Ixazomib Impurity 4. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2,5-dichloro-N-(2-((1-hydroxy-3-methylbutyl)amino)-2-oxoethyl)benzamide. Molecular Formula: C14H18Cl2N2O3. Mole Weight: 333.21. Catalog: APB02177. | |
| Ixazomib Impurity 44 | Ixazomib Impurity 44. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2,4,5-trichloro-N-(2-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-2-oxoethyl)benzamide. Molecular Formula: C24H32BCl3N2O4. Mole Weight: 528.15. Catalog: APB01507. | |
| Ixazomib Impurity 5 | Ixazomib Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-2,5-dichloro-N-(2-((1-hydroxy-3-methylbutyl)amino)-2-oxoethyl)benzamide. Molecular Formula: C14H18Cl2N2O3. Mole Weight: 333.21. Catalog: APB02179. | |
| Ixazomib Impurity 6 | Ixazomib Impurity 6. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2,5-dichloro-N-(2-((1-hydroperoxy-3-methylbutyl)amino)-2-oxoethyl)benzamide. Molecular Formula: C14H18Cl2N2O4. Mole Weight: 349.21. Catalog: APB02176. | |
| Ixazomib Impurity 64 | Ixazomib Impurity 64. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid. Molecular Formula: C14H19BCl2N2O4. Mole Weight: 360.08. Catalog: APB02165. | |
| Ixazomib Impurity 65 | Ixazomib Impurity 65. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-2,2'-(2-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid. Molecular Formula: C20H23BCl2N2O9. Mole Weight: 517.12. Catalog: APB02164. | |
| Ixazomib Impurity 66 | Ixazomib Impurity 66. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-(1-(2,5-dichlorobenzamido)-3-methylbutyl)boronic acid. CAS No. 2806031-79-6. Molecular Formula: C12H16BCl2NO3. Mole Weight: 303.06. Catalog: APB2806031796. | |
| Ixazomib Impurity 67 | Ixazomib Impurity 67. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(2,5-dichlorobenzamido)acetic acid. CAS No. 667403-46-5. Molecular Formula: C9H7Cl2NO3. Mole Weight: 246.98. Catalog: APB667403465. | |
| Ixazomib Impurity 68 | Ixazomib Impurity 68. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R) - (1- (2- (2- (2, 5-dichlorobenzamido) acetamido) acetamido) -3-methylbutyl) boronic acid. Molecular Formula: C16H22BCl2N3O5. Mole Weight: 417.10. Catalog: APB02163. | |
| Ixazomib Impurity 69 | Ixazomib Impurity 69. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R) -2, 2'- (2- (1- (2- (2- (2, 5-dichlorobenzamido) acetamido) acetamido) -3-methylbutyl) -5-oxo-1, 3, 2-dioxaborolane-4, 4-diyl) diacetic acid. Molecular Formula: C22H26BCl2N3O10. Mole Weight: 573.11. Catalog: APB02162. | |
| Ixazomib Impurity 70 | Ixazomib Impurity 70. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2,2'-(2-(3-methyl-1-(2-(2,3,5-trichlorobenzamido)acetamido)butyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid. Molecular Formula: C20H22BCl3N2O9. Mole Weight: 550.05. Catalog: APB02161. | |
| Ixazomib Impurity 9 | Ixazomib Impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1092351-67-1. Molecular Formula: C16H16N6O. Mole Weight: 308.35. Catalog: APB1092351671. | |
| MLN-9708 | ixazomib is an orally bioavailable second generation proteasome inhibitor (PI) with potential antineoplastic activity. Ixazomib inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first generation PIs, second generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquinated. Synonyms: Ixazomib; MLN-9708; MLN 9708; MLN9708. CAS No. 1201902-80-8. Molecular formula: C20H23BCl2N2O9. Mole weight: 517.12. | |
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