Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| JAK Inhibitor I | JAK Inhibitor I. Group: Biochemicals. Alternative Names: 2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one; DBI; Merck-5; Pyridone 6; DBI. Grades: Highly Purified. CAS No. 457081-03-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C18H16FN3O. US Biological Life Sciences. |  Worldwide |
| JAK Inhibitor I - CAS 457081-03-7 | JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC?? = 15 nM), JAK2 (IC?? = 1 nM), JAK3 (Ki = 5 nM) and Tyk2 (IC?? = 1 nM). Group: Fluorescence/luminescence spectroscopy. |  |
| JAK Inhibitor I (P6, DBI, (2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, Pyridone 6, JAK1 Inhibitor I, JAK3 Inhibitor VII, JAK2 Inhibitor I) | A potent, reversible, cell-permeable, and ATP-competitive inhibitor of Janus protein tyrosine kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC50=15nM for murine JAK1), JAK2 (IC50=1nM), JAK3 (Ki=5nM), and Tyk2 (IC50=1nM). Inhibits other kinases at much higher concentrations. Shown to inhibit IL2- and IL4-dependent proliferation of CTLL cells and block the phosphorylation of STAT5; and further induce growth inhibition of multiple myeloma cells expressing activated JAKs and STAT3, unlike AG 490. A 10mM solution of JAK Inhibitor I in DMSO is also available. Group: Biochemicals. Grades: Highly Purified. CAS No. 457081-03-7. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
| CP 690550 Citrate (Potent JAK Inhibitor, Tofacitinib citrate) ((3R,4R)-4-Methyl-3-(methyl-7H-pyrro lo[2,3-d]pyrimidin-4-ylamino)-b-oxo-1-piperidinepro panenitrile citrate) | Potent JAK inhibitor (IC50 values are 1, 20, and 112nm for JAK3, JAK2 and JAK1 respectively). Orally active immunosuppressant; exhibits efficacy in rodent rheumatoid arthritis models. Group: Biochemicals. Grades: Highly Purified. CAS No. 540737-29-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| InSolution JAK Inhibitor I - CAS 457081-03-7 | The JAK Inhibitor I, also referenced under CAS 457081-03-7, controls the biological activity of JAK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JAK2 Inhibitor II - CAS 1837-91-8 | The JAK2 Inhibitor II, also referenced under CAS 1837-91-8, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JAK2 Inhibitor III, SD-1029 | The JAK2 Inhibitor III, SD-1029, also referenced under CAS 118372-34-2, controls the biological activity of JAK2. Group: Fluorescence/luminescence spectroscopy. | |
| JAK2 Inhibitor IV | JAK2 Inhibitor IV is a potent and selective Janus Kinase 2 (JAK2) inhibitor that inhibits the activity of both the wild-type JAK2 and the V617F mutant (IC50 = 78 and 206 nM, respectively). Synonyms: JAK2 inhibitor 13. Grades: 99%. CAS No. 1110502-30-1. Molecular formula: C17H20N4O2S. Mole weight: 344.43. |  |
| JAK2 Inhibitor IV - CAS 1110502-30-1 | The JAK2 Inhibitor IV, also referenced under CAS 1110502-30-1, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JAK2 Inhibitor V, Z3 - CAS 195371-52-9 | The JAK2 Inhibitor V, Z3, also referenced under CAS 195371-52-9, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JAK3/GSK-3b/PKCa Inhibitor (3-(5-(4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1-yl)-2-trifluoromethyl-phenyl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione, NIBR3049, JAK3 Inhibitor XII) | A cell-permeable phenyl-indolyl maleimide compound that acts as a potent, ATP-binding site targeting and reversible inhibitor of GSK-3b, JAK3, PKCa and PKCth (IC50=3, 8, 13 and 68nM, respectively) with excellent selectivity over 40-kinases, including JAK1, JAK2 and Tyk2 (IC50=1.017, 2.55 and 8.055uM, respectively). Shown to efficiently block interleukin stimulated STAT5 phosphorylation and T cell costimulation (IC50=0.525, 1.294 and 0.689uM in IL15-MO7, IL2-CTLL and TCR/CD28-Jurkat cells, respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 1260181-14-3. Pack Sizes: 5mg. Molecular Formula: C??H??F?N?O?, Molecular Weight: 526.5. US Biological Life Sciences. | Worldwide |
| JAK3/GSK-3?/PKC? Inhibitor - CAS 1260181-14-3 | The JAK3/GSK-3?/PKC? Inhibitor, also referenced under CAS 1260181-14-3, controls the biological activity of JAK3/GSK-3?/PKC?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JAK3 Inhibitor I - CAS 202475-60-3 | The JAK3 Inhibitor I, also referenced under CAS 202475-60-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JAK3 Inhibitor II - CAS 211555-04-3 | The JAK3 Inhibitor II, also referenced under CAS 211555-04-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JAK3 Inhibitor IV - CAS 58753-54-1 | The JAK3 Inhibitor IV, also referenced under CAS 58753-54-1, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JAK3 Inhibitor, Negative Control - CAS 153437-07-1 | The JAK3 Inhibitor, Negative Control, also referenced under CAS 153437-07-1, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JAK3 Inhibitor V - CAS 932258 | The JAK3 Inhibitor V, also referenced under CAS 932258, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JAK3 Inhibitor VI - CAS 856436-16-3 | The JAK3 Inhibitor VI, also referenced under CAS 856436-16-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 | The JAK3 Inhibitor VII, AD412, also referenced under CAS 796041-65-1, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JAK3 Inhibitor VIII, NSC114792 | The JAK3 Inhibitor VIII, NSC114792 controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JAK3 Inhibitor VIII, NSC114792 (10, 13-Dimethyl-17- (2- (6-sulfanylidene-3H-purin-9-yl) acetyl) -1, 2, 6, 7, 8, 9, 11, 12, 14, 15, 16, 17-dodecahydrocyclopenta [a]phenanthren-3-one, Dimethyl-sulfanylidene-purinyl-acetyl-dodecahydrocyclopenta [a]phenanthren-3-one) | A cell-permeable steroidal-purinethione that targets JAK3 kinase domain and selectively inhibits JAK3, but not JAK1, JAK2, or TYK2, activity and effectively blocks the constitutive Jak3 and STAT5 phosphorylations (complete inhibition at 10uM) in BaF3-JAK3V674A and BLNK-/- BKO84 culltures. Shown to prevent the JAK3-dependent survival of L540, BaF3-JAK3WT, BaF3-JAK3V674A, and BLNK-/- BKO84 cells (by 40%, 50%, 57%, and 85%, respectively; 20uM; 72 h), while exhibiting no effect against the JAK3-independent growth in DU145, HDLM-2, and MDA-MB-468 cultures. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 1-(2,2-Difluoroethyl)-1H-pyrazol-4-amine | 1-(2,2-Difluoroethyl)-1H-pyrazol-4-amine acts as a reagent for the development of pyrimidine derivatives as JAK3 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1006333-08-9. Pack Sizes: 25mg, 100mg. Molecular Formula: C5H7F2N3, Molecular Weight: 147.13. US Biological Life Sciences. | Worldwide |
| 1,2,3,4,5,6-Hexabromocyclohexane | 1,2,3,4,5,6-Hexabromocyclohexane is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation. It inhibits JAK2 activation, and reduces growth hormone-mediated JAK2 autophosphorylation. Synonyms: Benzene Hexabromide; JAK2 Inhibitor II. Grades: >98%. CAS No. 1837-91-8. Molecular formula: C6H6Br6. Mole weight: 557.54. | |
| 1,5-Dimethylpyrazole-4-boronic acid | 1,5-Dimethylpyrazole-4-boronic Acid acts as a reagent in the preparation of pyrrolopyridazine JAK3 inhibitors and their use for treatment of inflammatory and autoimmune diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1204333-57-2. Pack Sizes: 50mg, 100mg. Molecular Formula: C5H9BN2O2, Molecular Weight: 139.949999999999. US Biological Life Sciences. | Worldwide |
| 1-Benzyl-4-methyl-3-piperidinamine | 1-Benzyl-4-methyl-3-piperidinamine is an intermediate of Tofacitinib (T528000); an enantiopure stereoisomer of the drug, Janus kinase 3(Jak3) inhibitor (CP-690,550) that has been found to inhibit selected members of the STE7 and STE20 subfamily of kinases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1039738-27-6. Pack Sizes: 250mg, 1g. Molecular Formula: C13H20N2, Molecular Weight: 204.31. US Biological Life Sciences. | Worldwide |
| 1-Benzylindole-5-boronic Acid Pinacol Ester | 1-Benzylindole-5-boronic Acid Pinacol Ester acts as a reagent in the synthesis of 3,3-difluoro-2-oxindoles via electrophilic fluorination of indoles using N-fluoro Benzene sulfonimide. Preparation of triazolopyridine compounds as JAK kinase inhibitors useful in the treatment of neurodegenerative and inflammatory diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1206163-56-5. Pack Sizes: 100mg, 250mg. Molecular Formula: C21H24BNO2, Molecular Weight: 333.23. US Biological Life Sciences. | Worldwide |
| (1R, 3S) -3- [ (tert-Butoxycarbonyl) amino] cyclopentanecarboxylic Acid | (1R, 3S) -3- [ (tert-Butoxycarbonyl) amino] cyclopentanecarboxylic Acid is used as a reagent in the sunthesis of Jak1 kinase inhibitors stemming from tricyclic pyrrolopyrazines. Group: Biochemicals. Grades: Highly Purified. CAS No. 161660-94-2. Pack Sizes: 50mg, 100mg. Molecular Formula: C11H19NO4, Molecular Weight: 229.27. US Biological Life Sciences. | Worldwide |
| 2- (1- (Ethylsulfonyl) azetidin-3-ylidene) acetonitrile | 2- (1- (Ethylsulfonyl) azetidin-3-ylidene) acetonitrile is an intermediate in the synthesis of Baricitinib, a JAK 1 and 2 inhibitor used in the treatment of rheumatoid arthritis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1187595-85-2. Pack Sizes: 1g, 5g. Molecular Formula: C7H10N2O2S, Molecular Weight: 186.23. US Biological Life Sciences. | Worldwide |
| 2,4-Dichloro-6-methoxypyrimidine | 2,4-Dichloro-6-methoxypyrimidine is an intermediate used to prepare piperazinyl pyrimidine derivatives as γ-secretase modulators. It is also used in the synthesis of α-azinylalkylamino-substituted (thiazolylamino) pyrimidines and -pyrazines as selective JAK2 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 43212-41-5. Pack Sizes: 100mg, 250mg. Molecular Formula: C5H4Cl2N2O, Molecular Weight: 179. US Biological Life Sciences. | Worldwide |
| 2-?Methoxypyridine-?4-?boronic Acid | 2-?Methoxypyridine-?4-?boronic Acid is a coupling reagent used in the synthesis of effacacious pyrrolopyridazines used as JAK1/3 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 762262-09-9. Pack Sizes: 500mg, 1g. Molecular Formula: C6H8BNO3, Molecular Weight: 152.94. US Biological Life Sciences. | Worldwide |
| (2S)-Ethylpyrrolidine Hydrochloride | (2S)-Ethylpyrrolidine Hydrochloride is used as a reagent in the synthesis of N,N'-substituted-1,3-diamino-2-hydroxypropanes for treating Alzheimer's disease. Also used as a reagent in the synthesis of cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK kinase inhibitors for treatment of autoimmune disease, cancer, inflammatory disease, and other diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 597562-96-4. Pack Sizes: 250mg, 2.5g. Molecular Formula: C6H14ClN, Molecular Weight: 135.639999999999. US Biological Life Sciences. | Worldwide |
| 3,3'-Diindolylmethane (3,3-Methylenediindole, DIM) | Diindolylmethane (DIM) is a natural compound present in food plants of the Brassica genus, including broccoli, cabbage, Brussels sprouts, cauliflower and kale. Displays antitumor and proapoptotic properties in animal and in in vitro models of cancer. Also acts a selective and potent inhibitor of cancer stem cells, and HDAC activity in prostate cancer cells. Recently, it has been shown that DIM induces apoptosis in ovarian cancer cells by inhibiting JAK2/STAT3. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg, 1g. US Biological Life Sciences. | Worldwide |
| 3-[4-Aminosulfonyl)phenyl]-2-propenoic Acid | 3-[4-Aminosulfonyl)phenyl]-2-propenoic Acid is a general chemical reagent used in the synthesis of pharmaceutical such as diazacyclicpyrrolopyri midine derivatives and analogs for use as JAK receptor and protein tyrosine kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 147723-92-0. Pack Sizes: 25mg, 50mg. Molecular Formula: C9H9NO4S, Molecular Weight: 227.24. US Biological Life Sciences. | Worldwide |
| 3-Chloro-4-nitrophenol | 3-Chloro-4-nitrophenol was used as a reactant in the synthetic preparation of highly potent BTK and JAK3 dual inhibitors and it may also have antifungal activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 491-11-2. Pack Sizes: 250mg, 500mg. Molecular Formula: C6H4ClNO3, Molecular Weight: 173.55. US Biological Life Sciences. | Worldwide |
| (3R,4S)-Tofacitinib | (3R,4S)-Tofacitinib is a less active enantiopure stereoisomer of the JAK3 inhibitor Tofacitinib. Synonyms: Tofacitinib Impurity A; 3-((3R,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile. Grades: >98%. CAS No. 1092578-46-5. Molecular formula: C16H20N6O. Mole weight: 312.27. | |
| (3S,4R)-Tofacitinib | (3S,4R)-Tofacitinib is a less active enantiopure stereoisomer of the JAK3 inhibitor Tofacitinib. Synonyms: Tofacitinib Impurity B; 3-((3S,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile. Grades: >98%. CAS No. 1092578-48-7. Molecular formula: C16H20N6O. Mole weight: 312.27. | |
| (3S,4S)-Tofacitinib | (3S,4S)-Tofacitinib is a less active enantiopure stereoisomer of the JAK3 inhibitor Tofacitinib. Synonyms: Tofacitinib Impurity C; 3-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile. Grades: >98%. CAS No. 1092578-47-6. Molecular formula: C16H20N6O. Mole weight: 312.27. | |
| 4-(2,6-Dichloropyrimidin-4-yl)-morpholine | A reactant used in the preparation of α-azinylalkylamino-substituted pyrimidines as JAK2 inhibitors. Group: Biochemicals. Alternative Names: 2,4-Dichloro-6-(morpholin-4-yl)pyrimidine; 2,4-Dichloro-6-morpholinopyrimidine; 6-Morpholino-2,4-dichloropyrimidine. Grades: Highly Purified. CAS No. 52127-83-0. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| 6BIO | Phosphoinositide-dependent kinase 1 (PDK1) inhibitor. Potent, reversible and ATP-competitive glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) inhibitor. JAK/STAT3 signaling inhibitor. Apoptosis inducer. Potent antiproliferative agent in malignant lymphoid cell. Group: Biochemicals. Alternative Names: (2'Z,3'E)-6-Bromoindirubin-3'-oxime. Grades: Highly Purified. CAS No. 667463-62-9. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C16H10BrN3O2. US Biological Life Sciences. | Worldwide |
| Abrocitinib | Abrocitinib is a seletive JAK1 inhibitor with IC50 value of 29 nM. Abrocitinib has been investigated for the treatment of plaque psoriasis. Synonyms: PF-04965842; N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide. Grades: >98%. CAS No. 1622902-68-4. Molecular formula: C14H21N5O2S. Mole weight: 323.415. | |
| Abrocitinib | Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC 50 s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 ( IC 50 , 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-04965842. CAS No. 1622902-68-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107429. |  |
| AC410 | AC410 is a Janus kinase 2 (JAK2) inhibitor with Kd of 0.18 nM. AC410 is selective for JAK2 and Kd is 2.5 nM for JAK1 and 5nM for JAK3. Phase I for the treatment of Autoimmune disorders and Inflammation is on-going. Uses: Autoimmune disorders; inflammation. Synonyms: AC410; AC 410; AC-410; (S)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol;1361415-86-2 (HCl). Grades: 98%. CAS No. 1361415-84-0. Molecular formula: C19H16FN5O. Mole weight: 349.40. | |
| AG-490 | Tyrphostin AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. Uses: Antineoplastic agents. Synonyms: Tyrphostin AG 490; AG-490; AG490. Grades: 0.98. CAS No. 133550-30-8. Molecular formula: C17H14N2O3. Mole weight: 294.31. | |
| AG 490 (Tyrphostin B42, N-benzyl-3, 4-dihydroxy-benzylidene cyanoacetamide) | Specific and potent JAK2 protein tyrosine kinase inhibitor. Also, inhibits EGF receptor autophosphorylation, with IC50 of 100nM. Inhibits DNA synthesis and cell growth; induces apoptosis. Blocks growth of leukemic cells in vitro and in vivo. Group: Biochemicals. Alternative Names: Tyrphostin B42. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| ASN-002 | ASN-002 (Gusacitinib) is a dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with an IC50 value of 5-46 nM. It has anti-cancer activity. Synonyms: Gusacitinib. Grades: ≥98% by HPLC. CAS No. 1425381-60-7. Molecular formula: C24H28N8O2. Mole weight: 460.5. | |
| At9283 | AT9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A/B, JAK2/3, Abl (T315I) and Flt3 (IC50s ranging from 1 to 30 nM). AT9283 inhibits growth and survival of multiple solid tumors in vitro and in vivo. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea;1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)ureaAT9283;AT9283, >=98%;N-cyclopropyl-N-[3-[5-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]Urea;Urea, N-cyclopropyl-N-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-. Product Category: Inhibitors. CAS No. 896466-04-9. Molecular formula: C19H23N7O2. Mole weight: 381.438. Purity: 0.997. Density: 1.45. Product ID: ACM896466049. Alfa Chemistry ISO 9001:2015 Certified. |  |
| AT9283 | AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50= 3, 3, 1.2, 1.1, and 4 nM, respectively). It also potently (IC50 = <1 μM) inhibits serine/threonine kinases as well as receptor and non-receptor tyrosine kinases. Synonyms: AT9283; AT 9283; AT-9283. Grades:>98%. CAS No. 896466-04-9. Molecular formula: C19H23N7O2. Mole weight: 381.43. | |
| AT9283 | AT9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A/B , JAK2/3 , Abl (T315I) and Flt3 ( IC 50 s ranging from 1 to 30 nM). AT9283 inhibits growth and survival of multiple solid tumors in vitro and in vivo [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 896466-04-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50514. | |
| AT-9283 L-lactate | AT9283 is a multikinase inhibitor, is also a small-molecule inhibitor of several kinases with potential antineoplastic activity. AT9283 binds to and inhibits Aurora kinases A and B, JAK2 (Janus kinase 2) and the kinase BCR-ABL, which may result in the inhibition of cellular division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Synonyms: AT 9283; AT9283. CAS No. 896466-76-5. Molecular formula: C19H23N7O2. Mole weight: 471.52. | |
| Atiprimod dihydrochloride | Atiprimod dihydrochloride is the dihydrochloride salt form of atiprimod, which is an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents. It is a JAK2 inhibitor with IC50 value of 397 nM. It has anti-inflammatory, antineoplastic, and anti-angiogenic activities. It inhibits the phosphorylation of signal transducer and activation of transcription 3 (STAT3) and STAT5. It downregulates the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1 and blocks the signaling pathways of interleukin-6, vascular endothelial growth factor (VEGF). It also inhibits cell growth, induction of cell cycle arrest, and apoptosis in cells expressing the JAK2V617F mutation. Synonyms: N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride. CAS No. 130065-61-1. Molecular formula: C22H46N2Cl2. Mole weight: 409.52. | |
| AZ-960 | AZ-960 is an ATP-competitive inhibitor of JAK2 with Ki value of 0.45 nM. It inhibits proliferation in a SET-2 human megakaryoblastic cell line harboring the JAK2V617F mutation with GI50 value of 33 nM. Synonyms: (S)-5-Fluoro-2-((1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonitrile; 3-Pyridinecarbonitrile, 5-fluoro-2-(((1S)-1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)-; 5-Fluoro-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-[(5-methyl-1H-pyrazol-3-yl)amino]nicotinonitrile. Grades: >98%. CAS No. 905586-69-8. Molecular formula: C18H16F2N6. Mole weight: 354.36. | |
| AZD1480 | AZD1480 is a novel ATP-competitive inhibitor of JAK1 and JAK2 with IC50 of 1.3nM and 0.26nM, respectively. Group: Biochemicals. Alternative Names: (S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| AZD-1480 | AZD1480 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. AZD1480 inhibits JAK2 activation, leading to the inhibition of the JAK/STAT (signal transducer and activator of transcription) signaling including activation of STAT3. Synonyms: AZD1480; AZD-1480; AZD 1480. Grades: 0.98. CAS No. 935666-88-9. Molecular formula: C14H14ClFN8. Mole weight: 348.77. | |
| Baricitinib | Baricitinib is a selective and orally bioactive inhibitor of JAK1 and JAK2. It has been approved by FDA for the treatment of rheumatoid arthritis (RA). Uses: The treatment of rheumatoid arthritis (ra). Synonyms: LY3009104; 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile; Olumiant. Grades: >98%. CAS No. 1187594-09-7. Molecular formula: C16H17N7O2S. Mole weight: 371.419. | |
| Baricitinib | Baricitinib (LY3009104; INCB028050) is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC 50 s of 5.9 nM and 5.7 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY3009104; INCB028050. CAS No. 1187594-09-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-15315. | |
| Baricitinib phosphate | Baricitinib, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM). Baricitinib has been approved by FDA for the treatment of rheumatoid arthritis (RA). Synonyms: INCB 028050; LY 3009104; INCB028050; LY3009104; LY-3009104; INCB-028050. Grades: >98%. CAS No. 1187595-84-1. Molecular formula: C16H20N7O6PS. Mole weight: 469.41. | |
| Baricitinib phosphate | Baricitinib phosphate (LY3009104 phosphate; INCB028050 phosphate) is a selective orally bioavailable JAK1 / JAK2 inhibitor with IC 50 of 5.9 nM and 5.7 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY3009104 phosphate; INCB028050 phosphate. CAS No. 1187595-84-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15315A. | |
| BBT594 | BBT594, also called as NVP-BBT594, a dihydroindole compound, originally developed as an inhibitor of wild-type and T315I-mutant BCR-ABL1, and then subsequently was shown to inhibit JAK2 activity (IC50 = 8nM ~ 29nM in murine models). The Type II JAK2 inhibitor NVP-BBT594 also displayed potent inhibition of HCV activity (EC50 < 1.5 mM). BBT594 impairs GDNF-RET signaling, a promising therapeutic target to enhance the sensitivity to aromatase inhibitor (AI) treatment and revert AI resistance in ER+ breast cancer cells. It also impairs GDNF-dependent growth of MCF7-LTED cells. Synonyms: 5-(6-acetamidopyrimidin-4-yl)oxy-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2,3-dihydroindole-1-carboxamide; BBT-594; BBT-594; BBT-594; NVP-BBT594; NVP BBT594; NVP BBT-594GTPL7584; SCHEMBL12972358; 5-(6-acetamidopyrimidin-4-yl)oxy-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2,3-dihydroindole-1-carboxamide. CAS No. 882405-89-2. Molecular formula: C28H30F3N7O3. Mole weight: 569.59. | |
| Benzene hexabromide | Benzene hexabromide, a bromohydrocarbon, is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation. Uses: Scientific research. Group: Signaling pathways. CAS No. 1837-91-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107594. | |
| BMS-911543 | BMS-911543 is an orally available JAK inhibitor with selectivity for JAK2. It inhibts JAK2, thereby preventing the JAK/STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3. This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation. Synonyms: BMS 911543. Grades: >98%. CAS No. 1271022-90-2. Molecular formula: C23H28N8O. Mole weight: 432.532. | |
| BMS-911543 | BMS-911543 is a selective JAK2 inhibitor, with IC 50 s of 1.1 nM, less selective at JAK1, JAK3 and TYK2 ( IC 50 , 75, 360, 66 nM, respectively). Uses: Scientific research. Group: Signaling pathways. CAS No. 1271022-90-2. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15270. | |
| BMT-1438 | BMT-1438 is a selective inhibitor of Janus kinase (JAK) family with less side effcts which is potentially used for the treatment of rheumatoid arthritis and other autoimmune diseases. It has a preference for JAK1 and JAK3. BMT-1438 showed excellent effect both in vitro and in a collagen-induced arthritis mouse model. Uses: The potential treatment of rheumatoid arthritis and other autoimmune diseases. Synonyms: BMT-1438; BMT 1438; BMT1438. | |
| BMX-IN-1 | A cell-permeable tricyclic quinoline-acrylamide compound that potently inhibits BMX and BTK kinase activity (IC50 = 8 and 10.4nM, respectively) by covalently targeting ATP-binding site cysteine, while being less potent against TEC family kinases TEC, JAK3, BLK with the same conserved cysteine (IC50 = 175, 377, and 653nM, respectively). Only PI 3-K gamma/PIK3CG, SBK1, PIP5K2C (by ≥94% at 1uM), and TXK (by 75% at 1uM) are significantly inhibited by BMX-IN-1 in a selectivity profiling against 437 other kinase constructs. Potently inhibits the proliferation of TEL-BMX transformed Ba/F3 Ba/F3 (GI50 = 25nM), while being much less effective against TEL-BLK, TEL-JAK1, TEL-JAK2, TEL-JAK3, or TEL-TYK2E957D transformed Ba/F3 (GI50 = ≥3.64uM) or a panel of 5 prostate cancer cell lines (GI50 ≥2.46uM). Group: Biochemicals. Alternative Names: N- (2-Methyl-5- (9- (4- (methylsulfonamido) phenyl) -2-oxobenzo[h][1, 6]naphthyridin-1 (2H) -yl) phenyl) acrylamide, BMX/BTK Inhibitor, Bruton's Tyrosine Kinase Inhibitor IV, BLK Inhibitor I, BMX Inhibitor I, JAK3 Inhibitor XIII, PI 3-K Inhibitor XX, PIP5K2C Inhibitor I, SBK1 Inhibitor I, TEC Inhibitor I, TXK Inhibitor I. Grades: Highly Purified. CAS No. 1431525-23-4. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| Brepocitinib | Brepocitinib (PF-06700841) is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC 50 s of 17 nM and 23 nM, respectively. Brepocitinib also inhibits JAK2 and JAK3 with IC 50 s of 77 nM and 6.49 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-06700841. CAS No. 1883299-62-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112708. | |
| Broussonin E | Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Powder. CAS No. 90902-21-9. Molecular formula: C17H20O4. Mole weight: 288.3. Purity: 0.98. IUPACName: 5-[3-(2-hydroxy-4-methoxyphenyl)propyl]-2-methoxyphenol. Canonical SMILES: COC1=CC(=C(C=C1)CCCC2=CC(=C(C=C2)OC)O)O. Product ID: ACM90902219. Alfa Chemistry ISO 9001:2015 Certified. Categories: Broussonneti. | |
| CEP33779 | CEP-33779 is a highly selective, orally active inhibitor of JAK2. It induces regression of established colorectal tumors, angiogenesis, and proliferation of tumor cells. Synonyms: CEP-33779; N-[3-(4-methylpiperazin-1-yl)phenyl]-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine. Grades: >98%. CAS No. 1257704-57-6. Molecular formula: C24H26N6O2S. Mole weight: 462.572. | |
| Cercosporamide | Cercosporamide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3. Cercosporamide effectively inhibits eIF4E phosphorylation as well as inibitiing inhibits Pkc1. Cercosporamide displays antiproliferative and proapoptotic activity in cancer cells in vitro. Group: Biochemicals. Alternative Names: (9aS) -8-Acetyl -9, 9a-di hydro-1, 3, 7-tri hydroxy-9a- methyl -9-oxo-4-dibenzofurancarboxamid e ; (S)-8-Acetyl -9, 9a-di hydro-1, 3, 7-tri hydroxy-9a- methyl -9-oxo-4-dibenzofurancarboxamid e ; (-)-Cercosporamide. Grades: Highly Purified. CAS No. 131436-22-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Cerdulatinib | Cerdulatinib, also known as PRT2070 and PRT062070, is a novel, oral, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Cerdulatinib preferentially inhibited JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types. IL2 mediated STAT5 Y694 was inhibited with an IC50 of 0.27uM, while IL4 mediated signaling to STAT6 Y641 and functional responses in B cells and monocytes, namely CD69, CD25, and CD23 up-regulation, were inhibited with IC50 within the range of 0.11uM to 0.57uM. It is currently being studied in patients with genetically-defined hematologic cancers, as well as for patients who have failed therapy due to relapse or acquired mutations. Synonyms: Cerdulatinib; PRT2070; PRT-2070; PRT 2070; PRT-062070; PRT 062070; PRT062070. CAS No. 1198300-79-6. Molecular formula: C20H27N7O3S. Mole weight: 445.542. | |
| Cerdulatinib | Cerdulatinib (PRT062070) is a selective Tyk2 inhibitor with an IC 50 of 0.5 nM. Cerdulatinib (PRT062070) also is a dual JAK and SYK inhibitor with IC 50 s of 12, 6, 8 and 32 for JAK1, 2, 3 and SYK, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PRT062070; PRT2070. CAS No. 1198300-79-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15999. | |
| Cerdulatinib hydrochloride | Cerdulatinib hydrochloride (PRT062070) is a selective, oral active and reversible ATP-competitive inhibitor of dual SYK and JAK , with IC 50 s of 32 nM, 0.5 nM, 12 nM, 6 nM and 8 nM for SYK and Tyk2 , JAK1 , 2 , 3 , respectively. Cerdulatinib hydrochloride could be used to research autoimmune disease and B-cell malignancies [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PRT062070 hydrochloride; PRT2070 hydrochloride. CAS No. 1369761-01-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15999A. | |
Our database is helping our users find suppliers everyday.
