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Cell permeable, non-fluorescent F-actin probe. Potent inducer of actin polymerization and stabilization. Competes with phallotoxins for actin binding. Antifungal and antiparasitic compound. Antiproliferative and anticancer compound. Apoptosis enhancer/inducer. Tool used for autophagy/phagocytosis research. Source:Isolated from Jaspis splendens. Group: Biochemicals. Grades: Highly Purified. CAS No. 102396-24-7. Pack Sizes: 50ug, 100ug. Molecular Formula: C36H45BrN4O6. US Biological Life Sciences.
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Jasplakinolide
Jasplakinolide acts as an actin stabilizing agent that stabilizes actin filaments and promotes actin polymerization. It is also a potent inhibitor of breast and prostrate carcinoma cell proliferation. It potently competes with phalloidin for actin binding and induces actin polymerization by stimulating actin filament nucleation in vitro. It induces polymerization of monomeric actin into amorphous masses and disrupts actin filaments in vivo. It is cell permeable and affects chromosome movement in studies. It has insecticidal, antiproliferative and fungicidal activity. It is useful for investigating cell processes mediated by actin depolymerization and polymerization. Synonyms: NSC 613009; NSC613009; NSC-613009; [2S-[1(S*),2R*,4E,6S*,8R*]]-N-[2-Bromo-N-[N-(8-hydroxy-2,4,6-trimethyl-1-oxo-4-nonenyl)-L-alanyl]-N-methyl-D-tryptophyl]-3-(4-hydroxyphenyl)-β-alanine ρ-Lactone; 1-Oxa-5,8,11-triazacyclononadecane β-alanine deriv.; (+)-Jasplakinolide; Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]. Grades: ≥97% by HPLC. CAS No. 102396-24-7. Molecular formula: C36H45BrN4O6. Mole weight: 709.67.
Jasplakinolide
Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (3S,6R,9R,13S,15R,16E,19S)-3,5,13,15,17,19-Hexamethyl-6-[(2-bromo-1H-indole-3-yl)methyl]-9-(4-hydroxyphenyl)-12-oxa-2,5,8-triazacyclononadeca-16-ene-1,4,7,11-tetraone. Product Category: Inhibitors. Appearance: Solid. CAS No. 102396-24-7. Molecular formula: C36H45BrN4O6. Mole weight: 709.7. Purity: 95%+. IUPACName: (4R,7R,10S,13S,15E,17R,19S)-7-[(2-Bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone. Canonical SMILES: CC1CC(OC(=O)CC(NC(=O)C(N(C(=O)C(NC(=O)C(CC(=C1)C)C)C)C)CC2=C(NC3=CC=CC=C32)Br)C4=CC=C(C=C4)O)C. Product ID: ACM102396247. Alfa Chemistry ISO 9001:2015 Certified.
2-Bromo-N-[N-[ (1, 1-dimethylethoxy) carbonyl]-L-alanyl]-N-methyl-D-tryptophan Methyl Ester is an intermediate in the synthesis of Jasplakinolide (J210700), an potent inhibitor of prostrate and breast carcinoma cell proliferation. Group: Biochemicals. Grades: Highly Purified. CAS No. 134781-89-8. Pack Sizes: 1mg. Molecular Formula: C21H28BrN3O5. US Biological Life Sciences.
2-Methyl-N- (4- ( (triisopropylsilyl) oxy) benzylidene) propane-2-sulfinamide is an impurity of intermediates in the synthesis of Jasplakinolide (J210700), an potent inhibitor of prostrate and breast carcinoma cell proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg, 250mg. Molecular Formula: C20H35NO2SSi. US Biological Life Sciences.
(2S, 4E, 6R, 8S) -8-[[ (1, 1-Dimethylethyl) dimethylsilyl]oxy]-2, 4, 6-trimethyl-4-nonenoic Acid Ethyl Ester is an intermediate in the synthesis of Jasplakinolide (J210700), an potent inhibitor of prostrate and breast carcinoma cell proliferation. Group: Biochemicals. Grades: Highly Purified. CAS No. 119433-08-8. Pack Sizes: 1mg, 5mg. Molecular Formula: C20H40O3Si, Molecular Weight: 356.62. US Biological Life Sciences.
(2S,4E,6R,8S)-8-Hydroxy-2,4,6-trimethyl-4-nonenoic Acid Ethyl Ester is an intermediate in the synthesis of substituent used in the preparation of Jasplakinolide (J210700), an potent inhibitor of prostrate and breast carcinoma cell proliferation. Group: Biochemicals. Grades: Highly Purified. CAS No. 943858-34-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C14H26O3, Molecular Weight: 242.35. US Biological Life Sciences.
(2S,4E,6S)-2,4,6-Trimethyl-7-oxo-7-[(4S)-2-oxo-4-(phenylmethyl)-3-oxazolidinyl]-4-heptenoic Acid Ethyl Ester is an intermediate in the synthesis of substituents used in the preparation of Jasplakinolide (J210700), an potent inhibitor of prostrate and breast carcinoma cell proliferation. Group: Biochemicals. Grades: Highly Purified. CAS No. 943858-30-8. Pack Sizes: 25mg, 100mg. Molecular Formula: C22H29NO5, Molecular Weight: 387.47. US Biological Life Sciences.
(2S,4E,6S)-7-Hydroxy-2,4,6-trimethyl-4-heptenoic Acid Ethyl Ester is an intermediate in the synthesis of substituents used in the preparation of Jasplakinolide (J210700), an potent inhibitor of prostrate and breast carcinoma cell proliferation. Group: Biochemicals. Grades: Highly Purified. CAS No. 943858-38-6. Pack Sizes: 25mg, 250mg. Molecular Formula: C12H22O3, Molecular Weight: 214.3. US Biological Life Sciences.
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3- (2-Bromo-1H-indol-3-yl) -2- ( (S) -2- ( (tert-butoxycarbonyl) amino) -N-methylpropanamido) propanoic N, N'-dicyclohexyl carbamimidic Anhydride
3- (2-Bromo-1H-indol-3-yl) -2- ( (S) -2- ( (tert-butoxycarbonyl) amino) -N-methylpropanamido) propanoic N, N'-dicyclohexyl carbamimidic Anhydride is an intermediate in the synthesis of Jasplakinolide, an potent inhibitor of prostrate and breast carcinoma cell proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C33H48BrN5O5. US Biological Life Sciences.
Worldwide
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