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| Product | Description | |
|---|---|---|
| JNJ 10181457 | JNJ 10181457. Group: Biochemicals. Alternative Names: 4- [3- [4- [Piperidinyl] but-1-ynyl] benzyl] morpholine. Grades: Highly Purified. CAS No. 544707-19-9. Pack Sizes: 10mg. Molecular Formula: C20H28N2O, Molecular Weight: 312.45. US Biological Life Sciences. |  Worldwide |
| JNJ 10181457 dihydrochloride | The hydrochloride salt form of JNJ 10181457, which has been found to be a histamine H3 receptor inhibitor and could be a brain penetrant. Synonyms: JNJ 10181457 dihydrochloride; JNJ10181457 dihydrochloride; JNJ-10181457 dihydrochloride; 4-[3-[4-[Piperidinyl]but-1-ynyl]benzyl]morpholine dihydrochloride. Grades: ≥98% by HPLC. CAS No. 544707-20-2. Molecular formula: C20H28N2O.2HCl. Mole weight: 385.37. |  |
| JNJ10181457 | JNJ10181457 dihydrochloride is a selective non-imidazole brain penetrant histamine H3 receptor antagonist with pKi values of 8.15 and 8.93 for rat and human H3 receptors respectively. It increases acetylcholine and extracellular norepinephrine levels in rat frontal cortex, but it does not stimulate dopamine release. It normalizes acetylcholine neurotransmission and shows efficacy in translational rat models of cognition. Uses: Jnj10181457 dihydrochloride normalizes acetylcholine neurotransmission. Synonyms: JNJ-10181457; JNJ10181457; JNJ 10181457; JNJ-10181457 dihydrochloride;4-[[3-(4-piperidin-1-ylbut-1-ynyl)phenyl]methyl]morpholine dihydrochloride. Grades: >98 %. CAS No. 544707-19-9. Molecular formula: C20H28N2O. Mole weight: 312.4. | |
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