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| Product | Description | |
|---|---|---|
| JNJ-17203212 | JNJ-17203212 is a novel, reversible, and selective TRPV1 antagonist which could not inhibit related TRP channels. Its IC50 values are 65 nM and 102 nM for human TRPV1 and rat TRPV1. It could reduce sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity. It inhibits capsaicin- and H+-induced channel activation, which pIC50 values are 6.32 and 7.23 respectively. It exhibits antitussive and analgesic activity in vivo. Uses: Jnj-17203212 could reduce sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity. it inhibits capsaicin- and h+-induced channel activation. it exhibits antitussive and analgesic activity in vivo. Synonyms: JNJ-17203212; JNJ 17203212; JNJ17203212. 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide;1-PiperazinecarboxaMide, 4-[3-(trifluoroMethyl)-2-pyridinyl]-N-[5-(trifluoroMethyl)-2-pyridinyl]-;N1-(3-Trifluoromethylpyrid-2-yl)-N4-(4-trifluoromethylpyrid-2-yl)carbamoylpiperazine. Grades: >99 %. CAS No. 821768-06-3. Molecular formula: C17H15F6N5O. Mole weight: 419.32. |  |
| JNJ-17203212 | JNJ-17203212 is a selective, potent and competitive TRPV1 antagonist. JNJ-17203212 is developed for researching pain management, such as migraine [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 821768-06-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100129. |  |
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