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| Product | Description | |
|---|---|---|
| JNJ-40411813 | JNJ-40411813, also known as ADX71149, is a positive allosteric modulator of the mGlu2 receptor. JNJ-40411813 acts as a PAM at the cloned mGlu2 receptor: EC50=147 ± 42 nmol/L in a [(35)S]GTPγS binding assay with human metabotropic glutamate type 2 (hmGlu2) CHO cells and EC50=64 ± 29 nmol/L in a Ca(2+) mobilization assay with hmGlu2 G α16 cotransfected HEK293 cells. JNJ-40411813 displaced [(3)H]JNJ-40068782 and [(3)H]JNJ-46281222 (mGlu2 receptor PAMs), while it failed to displace [(3)H]LY341495 (a competitive mGlu2/3 receptor antagonist). JNJ-40411813 is an interesting candidate to explore the therapeutic potential of mGlu2 PAMs, in in vivo rodents experiments as well as in clinical studies. Uses: Designed for use in research and industrial production. Additional or Alternative Names: JNJ-40411813; JNJ 40411813; JNJ40411813; ADX71149; ADX 71149; ADX-71149. Product Category: Others. Appearance: Solid powder. CAS No. 1127498-03-6. Molecular formula: C20H25ClN2O. Mole weight: 344.88. Purity: >98%. IUPACName: 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone. Canonical SMILES: ClC1=C(N2CCC(C3=CC=CC=C3)CC2)C=CN(CCCC)C1=O. Product ID: ACM1127498036. Alfa Chemistry ISO 9001:2015 Certified. |  |
| JNJ-40411813 | JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. Synonyms: JNJ-40411813; JNJ 40411813; JNJ40411813; ADX71149; ADX 71149; ADX-71149. Grades: >98%. CAS No. 1127498-03-6. Molecular formula: C20H25ClN2O. Mole weight: 344.88. |  |
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