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| Product | Description | |
|---|---|---|
| JPH203 | JPH203 Inhibitor. Uses: Scientific use. Product Category: TQ0081. CAS No. 1037592-40-7. |  |
| JPH203 | JPH203 is a potent and selective L-type amino acid transporter 1 (LAT1) inhibitor. It inhibits 14C-leucine uptake and cell growth in human colon cancer-derived HT-29 cells in vitro. It also inhibits 14C-leucine uptake in mouse renal proximal tubule cells expressing l-type amino acid transporter 1, and inhibits cell growth. It completely inhibits the proliferation of YD-38 cells in a dose- and time-dependent manner. It suppresses proliferation in cancer cell lines and is used for cancer research. It was developed by J-Pharma and in clinic phase 1 trials. Uses: Jph203 suppresses proliferation in cancer cell lines and is used for cancer research. Synonyms: KYT-0353;KYT0353;JPH-203; KYT 0353;JPH 203;(S)-2-amino-3-(4-((5-amino-2-phenylbenzo[d]oxazol-7-yl)methoxy)-3,5-dichlorophenyl)propanoic acid. Grades: >98 %. CAS No. 1037592-40-7. Molecular formula: C23H19Cl2N3O. Mole weight: 472.32. |  |
| JPH203 dihydrochloride | JPH203 is a potent and selective inhibitor of L-type amino acid transporter 1 (LAT1), which is highly expressed in many tumor cells. Study has shown that JPH203 inhibited L-leucine uptake, and increased apoptosis rates and formed DNA ladder in Saos2 cells. Synonyms: KYT 0353; O-[(5-Amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-L-tyrosine dihydrochloride; (2S)-2-amino-3-[4-[(5-amino-2-phenyl-1,3-benzoxazol-7-yl)methoxy]-3,5-dichlorophenyl]propanoic acid dihydrochloride. Grades: ≥96% by HPLC. CAS No. 1597402-27-1. Molecular formula: C23H19Cl2N3O4ยท2HCl. Mole weight: 545.24. | |
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