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| Product | Description | |
|---|---|---|
| JW 67 | JW 67. Group: Biochemicals. Grades: Purified. CAS No. 442644-28-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| JW 67 | JW 67 has been found to be a new antagonist of canonical Wnt signaling and exhibit activities in restraining growth and downregulated Wnt target genes in human colorectal cancer cells. Synonyms: JW 67; JW 67; JW 67; Trispiro[3H-indole-3,2'-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione. Grades: ≥97% by HPLC. CAS No. 442644-28-2. Molecular formula: C21H18N2O6. Mole weight: 394.38. |  |
| JW 67, Wnt pathway Inhibitor (Induces Degradation of Active B-catenin, Trispiro[3H-indole-3, 2'-[1, 3]dioxane--2'', 3'''-[3H]indole]-2, 2'''(1H, 1'''H)-dione) | Inhibitor of canonical Wnt pathway signaling (IC50 = 1.17um); targets the beta-catenin destruction complex (GSK-3beta/AXIN/APC) to induce beta-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-kappaB pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8um). Group: Biochemicals. Grades: Highly Purified. CAS No. 442644-28-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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