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| Product | Description | |
|---|---|---|
| k-252a | K-252a, a staurosporine analog, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 99533-80-9. Molecular formula: C27H21N3O5. Mole weight: 467.47. Purity: >98 %. Product ID: ACM99533809. Alfa Chemistry ISO 9001:2015 Certified. Categories: K252a. |  |
| K-252a | K-252a is an antibiotic, PKC, PKA and PKG inhibitor. Shows neurotropic activity by inducing neurite outgrowth. Highly potent cell permeable CaM kinase and phosphorylase inhibitor. Tyrosine protein kinase inhibitor of the TRK family. Antiproliferative and apoptosis inducer. Cell cycle arrest inducer. Potential drug for psoriasis treatment. Source:Isolated from Nonomuraea longicatena chiba. Group: Biochemicals. Grades: Highly Purified. CAS No. 99533-80-9. Pack Sizes: 100ug, 1mg. Molecular Formula: C27H21N3O5. US Biological Life Sciences. |  Worldwide |
| K-252a | Ready Made Solution, from Nonomuraea longicatena, >98%. Group: Fluorescence/luminescence spectroscopy. |  |
| K-252a, Nocardiopsis sp. - CAS 97161-97-2 | A cell-permeable, reversible, and ATP-competitive inhibitor against multiple protein kinases. Group: Fluorescence/luminescence spectroscopy. | |
| CEP 1347 | CEP 1347, also named KT 7515 or CHEMBL290352, an ethylthiomethyl derivative, is a potent, selective inhibitor of the cJun-amino terminal kinase pathway currently under clinical evaluation for the treatment of neurodegenerative diseases. It blocks Aβ-induced cortical neuron apoptosis (EC50 ~51 nM). Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: CHEMBL290352; CEP-1347; 3,9-Bis(etsm)-K-252a; CEP1347; 156177-65-0; CEP 1347; KT7515; 3,9-Bis((ethylthio)methyl)-K-252a; KT 7515; KT-7515; GTPL8173; SCHEMBL12047710; BDBM24942; CEP1374; CEP 1374; CEP-1374; ZINC3928304; AKOS024458422; KT-1575; 170587-65-2; 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 5,16-bis((ethylthio)methyl)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9S-(9alpha,10beta,12alpha))-; CEP 1347|(9S,10R,12R)-5-16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester; methyl (15S, 16R, 18R)-10, 23-bis[(ethylsulfanyl)methyl]-16-hydroxy-15-methyl-3-oxo-28-oxa-4, 14, 19-triazaoctacyclo[12.11.2.1^{15, 18}.0^{2, 6}.0^{7, 27}.0^{8, 13}.0^{19, 26}.0^{20, 25}]octacosa-1, 6, 8, 10, 12, 20, 22, 24, 26-nonaene-16-carboxylate. CAS No. 156177-65-0. Molecular formula: C33H33N3O5S2. Mole weight: 615.76. |  |
| KT5720 - CAS 108068-98-0 | A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modification of K-252a. Group: Fluorescence/luminescence spectroscopy. | |
| KT5823 (2, 3, 9, 10, 11, 12- hexahydro- 10R- methoxy- 2, 9- dimethyl- 1- oxo- 9S, 12R- epoxy- 1H- diindolo[1, 2, 3- fg:3, 2, 1- kl]pyrrolo[3, 4- i][1, ]benzodiazocine- 10- carboxylic acid, methyl ester) | Cell-permeable. KT5823 is a derivative of K-252a that acts as a selective inhibitor of Protein kinase G (PKG) (Ki = 0.234um). Inhibits other kinases at much higher concentrations (Kis for PKA=4um and for MLCK=>10um). Group: Biochemicals. Grades: Highly Purified. CAS No. 126643-37-6. Pack Sizes: 50ug. US Biological Life Sciences. | Worldwide |
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