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| Product | Description | |
|---|---|---|
| K02288 | >98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| K02288 | K02288 is a highly selective 2-aminopyridine based inhibitor with in vitro activity against ALK2 at low nanomolar concentrations similar to the current lead compound LDN-193189. K02288 specifically inhibits the BMP-induced Smad pathway without affecting TGF-b signaling and induced dorsalization of zebrafish embryos. Synonyms: K-02288; 3-(6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenol. Grades: >98%. CAS No. 1431985-92-0. Molecular formula: C20H20N2O4. Mole weight: 352.38. |  |
| K02288 | K02288 is a potent bone morphogenetic protein (BMP) type I receptor inhibitor with IC50s of 1.8, 1.1, 6.4 nM for ALK1, ALK2 and ALK6, respectively. K02288 shows slightly weaker inhibition against ALK3 and ALK6 with IC50s of of 5-34 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1431985-92-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-12278. |  |
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