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| Product | Description | |
|---|---|---|
| K145 | K145 is a selective sphingosine kinase-2 (SphK2) inhibitor and anticancer agent. K145 inhibited the activity of SphK2 in a dose-dependent manner with an IC50 of 4.30±0.06 μM. K145 also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells. K145 exhibits comparable in vivo anti-tumor activity to tamibarotene, while concomitantly exhibiting less toxicity in this U937 xenograft cancer model. Synonyms: SphK2 inhibitor; K 145; K-145. Grades: >98%. CAS No. 1309444-75-4. Molecular formula: C18H24N2O3S. Mole weight: 348.46. |  |
| K145 hydrochloride | K145 (3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione) is a selective inhibitor of sphingosine kinase-2 (SphK2) and an anticancer agent. K145 selectively inhibited SphK2 in a dose-dependent manner with an IC50 of 4.30 +/- 0.06 μM with no inhibition of SphK1 at concentrations up to 10 μM. K145 significantly suppressed the growth of U937 tumors in nude mice and the growth of JC tumor cells in BALB/c mice. Synonyms: SphK2 inhibitor; K 145 hydrochloride; K-145 hydrochloride. Grades: >98%. CAS No. 1449240-68-9. Molecular formula: C18H25ClN2O3S. Mole weight: 384.92. | |
| K145 hydrochloride | K145 hydrochloride is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC 50 of 4.3 μM and a K i of 6.4 μM. K145 hydrochloride is inactive against SphK1 and other protein kinases. K145 hydrochloride induces cell apoptosis and has potently antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1449240-68-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15779A. |  |
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