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K252a (2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-(9S,10R,12R)-9,12-epoxy-1H-diindolo[1,2,3-fg:3,2,1-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic Acd Methyl Ester, Antibiotic K252a, Antibiotic SF 2370, SF 2370) Quick inquiry Where to buy Suppliers range | K252a is an alkaloid isolated from Nocardiopsis sp. soil fungi. This compound is a highly potent cell permeable CaM Kinase II inhibitor (IC50=1.8nM). At higher concentrations it also inhibits broad spectrum of protein kinases (1-8). It is an excellent research tool of NGF receptors-trk-signal transduction due to its potent inhibition of trk-NGF receptor-tyrosine kinase activity. Group: Biochemicals. Alternative Names: 2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-(9S,10R,12R)-9,12-epoxy-1H-diindolo[1,2,3-fg:3,2,1-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic Acd Methyl Ester; Antibiotic K252a; Antibiotic SF 2370; SF 2370. Grades: Highly Purified. CAS No. 97161-97-2. Pack Sizes: 500ug, 5mg. US Biological Life Sciences. | Worldwide |
k252a Quick inquiry Where to buy Suppliers range | k252a. Group: Heterocyclic Organic Compound. Alternative Names: k252;(9S,10R,12R)-2,3,9,10,11,12-HEXAHYDRO-10-HYDROXY-9-METHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID METHYL ESTER;K-252A;K-252A, NOCARDIOPSIS SP;PROTEIN KINASE INHIBITOR;PROTEIN KINASE INHI. CAS No. 97161-97-2. Product ID: ACM97161972. Molecular formula: C27H21N3O5. Mole weight: 467.47. Appearance: White Solid. | |
K252a Quick inquiry Where to buy Suppliers range | K252a. Group: Biochemicals. Alternative Names: 2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-(9S,10R,12R)-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acd methyl ester; Antibiotic K252a; Antibiotic SF 2370. Grades: Highly Purified. CAS No. 97161-97-2. Pack Sizes: 1mg, 2mg, 5mg. Molecular Formula: C27H21N3O5. US Biological Life Sciences. | Worldwide |
Antibiotic K252A (Antibiotic SF 2370) Quick inquiry Where to buy Suppliers range | Antibiotic K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. Antibiotic K252A exhibits potent antitumor activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. More extensive investigation has demonstrated that while antibiotic K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG). Group: Biochemicals. Grades: Highly Purified. CAS No. 99570-78-2. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |