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| Product | Description | |
|---|---|---|
| Kallikrein Inhibitor | Kallikrein Inhibitor, a synthetic peptide, is a serine protease inhibitor that inhibits kallikrein and plasmin, and can attenuate breast cancer cell invasion. Synonyms: KKI 5; KKI-5; KKI5; Ac-Pro-phe-arg-ser-val-gln-NH2; (S)-2-((3S,6S,9S,12S)-1-((S)-1-acetylpyrrolidin-2-yl)-3-benzyl-6-(3-guanidinopropyl)-9-(hydroxymethyl)-12-isopropyl-1,4,7,10-tetraoxo-2,5,8,11-tetraazatridecan-13-amido)pentanediamide; N-acetyl-L-prolyl-L-phenylalanyl-L-arginyl-L-seryl-L-valyl-L-glutaminamide. Grades: >98%. CAS No. 97145-43-2. Molecular formula: C35H55N11O9. Mole weight: 773.88. |  |
| 1,4:3,6-Dianhydro-D-mannitol | 1,4:3,6-Dianhydro-D-mannitol is a reagent used in the synthesis of new isomannide-based peptidomimetic as human tissue kallikrein 1 inhibitor using Ugi multicomponent reaction. It also functions as a chiral ligand for stereoselective synthesis. Group: Biochemicals. Grades: Highly Purified. CAS No. 641-74-7. Pack Sizes: 1g, 5g. Molecular Formula: C6H10O4, Molecular Weight: 146.139999999999. US Biological Life Sciences. |  Worldwide |
| 2-(Bromomethyl) Oxazole | 2-(Bromomethyl) Oxazole is used in the synthetic preparation of substituted oxopyridine derivatives as factor XIa and plasma kallikrein inhibitors useful in treating thrombotic or thromboembolic diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1065073-35-9. Pack Sizes: 25mg, 100mg. Molecular Formula: C4H4BrNO, Molecular Weight: 161.979999999999. US Biological Life Sciences. | Worldwide |
| AEBSF HCl | AEBSF is a water-soluble, irreversible serine protease inhibitor that inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. Synonyms: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride; AEBSF hydrochloride; AEBSF. Grades: 98%. CAS No. 30827-99-7. Molecular formula: C8H11ClFNO2S. Mole weight: 239.69. | |
| AEBSF hydrochloride | AEBSF hydrochloride is an irreversible inhibitor of serine proteases , such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. Uses: Scientific research. Group: Signaling pathways. CAS No. 30827-99-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg. Product ID: HY-12821. |  |
| Aprotinin, Bovine (Pancreatic trypsin inhibitor) | Aprotinin is a competitive serine protease inhibitor that inhibits trypsin, chymotrypsin, kallikrein and plasmin. Aprotinin forms stable complexes with and blocks the active sites of enzymes. Binding is reversible with most aprotinin-protease complexes, dissociating at pH >10 or <3. Effective concentration is equimolar with protease. Group: Biochemicals. Alternative Names: Antikrein; Antilysin; Antilysine; Aprostat; Aprotinin; BPTI; BPTI Trypsin Inhibitor; Basic Pancreatic Trypsin Inhibitor; Bayer A 128; Bovine Basic Pancreatic Trypsin Inhibitor; Bovine Pancreatic Trypsin Inhibitor; Bovine Trypsin Inhibitor; Fosten; Kallikrein-trypsin Inactivator; Kiker 52G; Kir Richter; Kunitz Pancreatic Trypsin Inhibitor; Kunitz Protease Inhibitor; Kunitz Trypsin Inhibitor; Kunitz-type Inhibitor; Kunitz-type Proteinase Inhibitor; Kunitz-type Trypsin Inhibitor; Onquinin; Pancreatic Basic Trypsin Inhibitor; Pancreatic Trypsin Inhibitor; Pancreatic Trypsin Inhibitor (Kunitz); Protease Inhibitor, Kunitz Type; RP 9921; Repulson; Trasuylol; Trasylol; Trazinin; Triazinin; Trypsin Inhibitor, Trasylol; Trypsin-kallikrein Inhibitor (Kunitz); Zymofren. Grades: Highly Purified. CAS No. 9087-70-1. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C???H???N??O??S?, Molecular Weight: 6511.45. US Biological Life Sciences. | Worldwide |
| Avoralstat | Avoralstat, also known as BCX-4161, is an oral plasma kallikrein (PKK) inhibitor and Bradykinin inhibitor, used to treat hereditary angioedema. Synonyms: 3-[2-[(4-carbamimidoylphenyl)carbamoyl]-4-ethenyl-5-methoxyphenyl]-6-(cyclopropylmethylcarbamoyl)pyridine-2-carboxylic acid; BCX-4161; BCX 4161; BCX4161; Avoralstat. CAS No. 918407-35-9. Molecular formula: C28H27N5O5. Mole weight: 513.54. | |
| Avoralstat | Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BCX4161. CAS No. 918407-35-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16735. | |
| Berotralstat | Berotralstat (BCX7353) is an orally active plasma kallikrein inhibitor. Berotralstat can reduce brain edema and is being studied for glioblastoma and hereditary angioedema [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BCX7353. CAS No. 1809010-50-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-109127. | |
| Berotralstat dihydrochloride | Berotralstat dihydrochloride is a low toxicity, effective, highly specific, second-generation, synthetic and orally active plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat dihydrochloride works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BCX7353 dihydrochloride. CAS No. 1809010-52-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109127A. | |
| Camostat Mesylate | Orally active, non-peptide proteolitic enzyme inhibitor with anti-trypsin and anti-plasmin activities, related structurally to gabexate. Protease inhibitor. Camostat mesilate is a serine protease inhibitor that inhibits plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancreatic fibrosis. It reduces weight gain and improves metabolism in obese rodent models. It is in clinical use (in Japan) for pancreatitis. Camostat has been found to inhibit influenza virus replication in human tracheal epithelial cells and is also a direct prostasin inhibitor which may be useful in reducing sodium transport in cystic fibrosis. Additionally it has been shown to reduce infection of Calu-3 lung cells by SARS-CoV-2 (the coronavirus responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming. Group: Biochemicals. Alternative Names: 4- [ [4- [ (Aminoiminomethyl) amino] benzoyl] oxy] benzeneacetic Acid 2-(Dimethylamino)-2-oxoethyl Ester Methanesulfonate; FOY 305; FOY-S 980; Foipan. Grades: Highly Purified. CAS No. 59721-29-8. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| Chymostatin | Chymostatin is a bioactive peptide that acts as a protease inhibitor with selectivity for chymotryptase-like serine proteases. It potently inhibits chymotrypsin and chymase, but it cannot block the activity of cathepsins, papain, and leukocyte elastase effectively. It doesn't have effect on trypsin, thrombin, plasmin, pepsin, and kallikrein. Uses: Serine proteinase inhibitors. Synonyms: [(S)-1-Carboxy-2-phenylethyl]-carbamoyl-a-[2-amidohexahydro-4(S)-pyrimidyl]-(S)-glycyl-[A= Leu B=Val C=Ile]-phenylalaninal (Mixture). Grades: ≥95% (a mixture of A, B, C). CAS No. 9076-44-2. Molecular formula: CxHyN7O6. Mole weight: 607.7. | |
| Darexaban | Darexaban (YM150) is a potent, selective and orally active factor Xa (FXa) inhibitor with an IC 50 of 54.6 nM. Darexaban shows high selectivity against other related serine proteases, such as trypsin, thrombin, and kallikrein. Darexaban has anticoagulant and antithrombotic effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: YM150. CAS No. 365462-23-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14853. | |
| D-Pro-Phe-Arg-Chloromethylketone | D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma kallikrein, plays an important role in thrombosis and inflammation[1]. Uses: Scientific research. Group: Peptides. CAS No. 88546-74-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4245. | |
| FE-999024 | FE-999024, a dipeptide compound, has been found to be a kallikrein inhibitor that was once studied in pancreatitis by Ferring Pharmaceuticals. Synonyms: FE-999024; FE 999024; FE999024; CH-2856; CH2856; CH 2856; L-Alaninamide, 4-chloro-D-phenylalanyl-N-(3-((aminoiminomethyl)amino)propyl)-3-(1-naphthalenyl)-. Grades: 98%. CAS No. 168825-65-8. Molecular formula: C26H31ClN6O2. Mole weight: 495.02. | |
| Gabexate mesylate | Gabexate is a serine protease inhibitor that inhibits trypsin (IC50= 9.4μM), plasmin (IC50= 30μM), plasma kallikrein (IC50= 41μM) and thrombin (IC50= 110μM). It is used therapeutically (as gabexate mesilate) in the treatment of pancreatitis, disseminated intravascular coagulation, and as a regional anticoagulant for haemodialysis. Synonyms: 4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxy]-benzoic acid ethyl ester mesylate; Gabexate; Gabexate mesylate; gabexate mesilate. Arodate; Megacart; Megacert; Mesyl Gabexate; Arodate. CAS No. 56974-61-9. Molecular formula: C17H27N3O7S. Mole weight: 417.48. | |
| Gabexate Mesylate | Gabexate Mesylate is a serine protease inhibitor. Gabexate Mesylate inhibits trypsin, plasmin, plasma kallikrein and thrombin. Gabexate Mesylate inhibits lipopolysaccharide-induced tumor necrosis factor-α (TNF-α) production through nuclear factor-κB and activator protein-1 activation. Group: Biochemicals. Alternative Names: 4-[[6-[ (Aminoiminomethyl) amino]-1-oxohexyl]oxy]benzoic Acid Ethyl Ester Monomethanesulfonate; Arodate; FOY; FOY 007; FOY-S 983; Gabexate Mesilate; Gabexate Monomethanesulfonate; Megacert; Mesyl Gabexate. Grades: Highly Purified. CAS No. 56974-61-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| H-D-Phe-Phe-Arg-chloromethylketone | H-D-Phe-Phe-Arg-chloromethyl ketone is a potent, specific and irreversible inhibitor of glandular and plasma kallikreins. Uses: Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Synonyms: FFRCK; Phenylalanyl-phenylalanyl-arginine chloromethyl ketone; Phe-phe-arg-CK; 2-Amino-N-[N-(6-carbamimidamido-1-chloro-2-oxohexan-3-yl)phenylalanyl]-3-phenylpropanimidic acid; PPACK II. CAS No. 74392-49-7. Molecular formula: C25H33ClN6O3. Mole weight: 501.02. | |
| Isomannide | Isomannide (CAS# 641-74-7) is a reagent used in the synthesis of new isomannide-based peptidomimetic as human tissue kallikrein 1 inhibitor using Ugi multicomponent reaction. It also functions as a chiral ligand for stereoselective synthesis. Synonyms: D-Mannitol, 1,4:3,6-dianhydro-; 1,4:3,6-Dianhydro-D-mannitol; Mannitol, 1,4:3,6-dianhydro-, D-; (+)-Isomannide; (3R,3aR,6R,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diol; 1,4:3,6-Dianhydromannitol; D-Isomannide; Dianhydromannitol; NSC 270938. Grades: ≥95%. CAS No. 641-74-7. Molecular formula: C6H10O4. Mole weight: 146.14. | |
| Kallikrein 5-IN-2 | Kallikrein 5-IN-2 (compound 21) is a selective Kallikrein KLK5 inhibitor (pIC 50 =7.1). KLK5 inhibition may normalise epidermal shedding and reduce the associated inflammation and itching [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2361160-57-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-148949. | |
| Lanadelumab | Lanadelumab (SHP643) is a human IgG1 monoclonal antibody against plasma kallikrein (pKal) with an K i value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: SHP643; DX-2930. CAS No. 1426055-14-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99110. | |
| LM-030 | LM-030 (BPR277) is a potent kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2) inhibitor with IC 50 s of 6 nM and 55 nM, respectively(Example 4) [1]. LM-030 can be used for the study of Netherton syndrome [2]. Uses: Scientific research. Group: Peptides. Alternative Names: BPR277. CAS No. 1122484-55-2. Pack Sizes: 1 mg. Product ID: HY-P4669. | |
| MDI-2268 | MDI-2268 is an inhibitor of plasma kallikrein inhibitor 1 (PAI-1). MDI-2268 has good antithrombotic properties and regulates blood coagulation and fibrinolysis process by enhancing fibrinolysis. MDI-2268 can be used in research areas such as deep vein thrombosis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1609176-50-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124577. | |
| Nafamostat | Nafamostat is a broad spectrum serine protease inhibitor and kallikrein inhibitor. It inhibits blood coagulation and used as an anticoagulant. It is also a possible complement inhibitor. It is mainly used during hemodialysis to prevent the proteolysis of fibrinogen into fibrin. It is formulated with HCl salt due to its basic tendencies. Uses: Nafamostat inhibits blood coagulation and used as an anticoagulant. it is also a possible complement inhibitor. it is mainly used during hemodialysis to prevent the proteolysis of fibrinogen into fibrin. Synonyms: FUT-175; FUT 175; FUT175; 6-Amidino-2-naphthyl 4-guanidinobenzoate;(6-carbamimidoylnaphthalen-2-yl) 4-(diaminomethylideneamino)benzoate; Benzoic acid,4-[(aminoiminomethyl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester. Grades: 95%. CAS No. 81525-10-2. Molecular formula: C19H17N5O2. Mole weight: 347.37. | |
| PKSI-527 | PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 128837-71-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123133. | |
| PKSI-527 | PKSI-527 is a potent and selective inhibitor of plasma kallikrein with Ki value of 0.81 μM. PKSI-527 may be a useful tool for exploring the mechanism of disseminated intravascular coagulation (DIC) and the accompanying organ failure. Synonyms: 2-[4-[[ (2S) -2-[[4- (aminomethyl) cyclohexanecarbonyl]amino]-3-phenylpropanoyl]amino]phenyl]acetic acid hydrochloride. Grades: ≥95%. CAS No. 128837-71-8. Molecular formula: C25H31N3O4·HCl. Mole weight: 474. | |
| PPACKII trifluoroacetate salt | PPACKII is a specific and irreversible inhibitor of glandular and plasma kallikreins. Human tissue kallikreins (hKs) are a class of secreted serine proteases that is involved in the release of vasodepressor peptides or kinins from a plasma substrate. Synonyms: H-D-Phe-Phe-Arg-Chloromethyl Ketone; (2R)-2-amino-N-[(2S)-1-[[(3S)-1-chloro-6-(diaminomethylideneamino)-2-oxohexan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]-3-phenylpropanamide trifluoroacetate salt. Grades: ≥95%. CAS No. 649748-23-2. Molecular formula: C25H33ClN6O3·2CF3COOH. Mole weight: 729.1. | |
| Sebetralstat | Sebetralstat (KVD900) is a plasma kallikrein inhibitor (WO2016083820). Sebetralstat can be used for the research of metabolic diseases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KVD900. CAS No. 1933514-13-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132830. | |
| Sebetralstat | Sebetralstatum is a kallikrein inhibitor. Synonyms: N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyridin-1(2H)-yl)methyl]phenyl}methyl)-1H-pyrazole-4-carboxamide. Grades: >98%. CAS No. 1933514-13-6. Molecular formula: C26H26FN5O4. Mole weight: 491.5. | |
| Sivelestat | Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki=0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase. Synonyms: EI546; EI 546; EI-546; LY544349; LY 544349; LY-544349; ONO5046; ONO-5046; ONO 5046. Grades: >98%. CAS No. 127373-66-4. Molecular formula: C20H22N2O7S. Mole weight: 434.46. | |
| Sivelestat sodium tetrahydrate | Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki=0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase. Uses: Serine proteinase inhibitors. Synonyms: EI546 sodium tetrahydrate; EI 546 sodium tetrahydrate; EI-546 sodium tetrahydrate; LY544349 sodium tetrahydrate; LY 544349 sodium tetrahydrate; LY-544349 sodium tetrahydrate; ONO5046 sodium tetrahydrate; ONO 5046 sodium tetrahydrate; ONO-5046 sodium tetrahydrate. Grades: >98%. CAS No. 201677-61-4. Molecular formula: C20H29N2NaO11S. Mole weight: 528.51. | |
| Trypsin Inhibitor (soybean) | Trypsin Inhibitor (soybean) is a peptide inhibitor of serine proteases that reduces trypsin, as well as plasma kallikrein, thrombin, plasmin, and other serine proteases. Synonyms: Kunitz Trypsin Inhibitor; MR 20; SBTI. CAS No. 9035-81-8. | |
| Ulinastatin | Ulinastatin is an acid-resistant protease inhibitor derived from human urine, acting as a potent anti-inflammatory agent. It was shown to inhibit the activities of a variety of enzymes, including trypsin, chymotrypsin, thrombin, kallikrein, plasmin, elastase, cathepsin, lipase, hyaluronidase, factors IXa, Xa, XIa, and XlIa, and polymorphonuclear leukocyte elastase. Synonyms: Urinastatin; 2,4-Dioxaspiro[5.5]undec-8-ene, 3-(2-furanyl)-. Grades: 95%. CAS No. 80449-31-6. Molecular formula: C13H16O3. Mole weight: 220.26. | |
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