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| Product | Description | |
|---|---|---|
| Kenpaullone | Kenpaullone. Group: Biochemicals. Grades: Purified. CAS No. 142273-20-9. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Kenpaullone | Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3β , with IC 50 s of 0.4 μM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC 50 s of 0.68 μM, 7.5 μM, 0.85 μM, respectively. Kenpaullone, a small molecule inhibitor of KLF4 , reduces self-renewal of breast cancer stem cells and cell motility in vitro. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 9-Bromopaullone; NSC-664704. CAS No. 142273-20-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12302. |  |
| Kenpaullone | Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC50 = 400 nM), CDK2/cyclin A (IC50 = 680 nM), CDK2/cyclin E (IC50 = 7.5 uM) and CDK5/p25 (IC50 = 850 nM). Kenpaullone inhibits CDK2/cyclin A, CDK2/cyclin E and CDK5/cyclin/p35 (IC50 values are 0.68, 7.5 and 0.85 μM respectively). Uses: Reprogramming. Synonyms: NSC664704; NSC-664704; NSC 664704; 9-Bromopaullone; 1-azakenpaullone; Kenpaullone. Grades: 98%. CAS No. 142273-20-9. Molecular formula: C16H11BrN2O. Mole weight: 327.18. |  |
| Kenpaullone (8-Bromo-7,12-dihydro-indolo[3,2-d][1]-benzazepin-6(5H)-one) | The paullones are a novel class of kinase inhibitors, initially identified as CDK inhibitors. Kenpaullone has been found to be a useful GSK-3ß inhibitor (IC50=23nM). Group: Biochemicals. Alternative Names: 8-Bromo-7,12-dihydro-indolo[3,2-d][1]-benzazepin-6(5H)-one. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3-[(4-Ethoxy-1,4-dioxobutyl)amino]-2-pyridinecarboxylic Acid Ethyl Ester | A synthetic intermediate for the synthesis of 1-Azakenpaullone and other Kenpaullone. Group: Biochemicals. Alternative Names: 3-[(4-Ethoxy-4-oxobutanoyl)amino]-2-pyridinecarboxylic Acid Ethyl Ester. Grades: Highly Purified. CAS No. 676596-61-5. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 5H-Pyrido[3,2-b]azepine-6,9-(7H,8H)-dione | A synthetic intermediate for the synthesis of 1-Azakenpaullone and other Kenpaullone derivatives. Group: Biochemicals. Alternative Names: 7,8-Dihydro-5H-pyrido[3,2-b]azepine-6,9-dione. Grades: Highly Purified. CAS No. 676596-63-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Alsterpaullone | Alsterpaullone is a potent glycogen synthase kinase-3 inhibitor and a potential therapeutic agent for the treatment of Parkinson disease. Alsterpaullone is also known as 9-Nitropaullone and NSC 705701, which is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Alsterpaullone induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Alsterpaullone is a derivative of kenpaullone with slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively. Synonyms: 9-Nitropaullone; NSC 705701; 7,12-Dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one. Grades: ≥98%. CAS No. 237430-03-4. Molecular formula: C16H11N3O3. Mole weight: 293.3. | |
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