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| Product | Description | |
|---|---|---|
| Ketanserin | An antihypertensive, with affinity for multiple GPCR receptors. Group: Biochemicals. Alternative Names: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione; Ketensin; R 41468. Grades: Highly Purified. CAS No. 74050-98-9. Pack Sizes: 50mg. US Biological Life Sciences. |  Worldwide |
| Ketanserin | Ketanserin is a selective 5-HT2 receptor antagonist. Ketanserin also blocks hERG current ( I hERG ) in a concentration-dependent manner ( IC 50 =0.11 μM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: R41468. CAS No. 74050-98-9. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10562. |  |
| Ketanserin | Ketanserin is a specific 5-HT2A serotonin receptor antagonist with Ki of 2.5 nM for rat and human 5-HT2A, used as an antihypertensive drug. Uses: Antihypertensive agents. Synonyms: Ketanserinum; Ketaserin; 3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione. CAS No. 74050-98-9. Molecular formula: C22H22FN3O3. Mole weight: 395.434. |  |
| Ketanserinol | Ketanserinol (R 46742) is a metabolite of Ketanserin (HY-10562). Ketanserinol is a competitive antagonist of the effects of 5-HT (HY-B1473A) in both arteries. The K B values are 6.5 for large coronary arteries and 6.4 for pulmonary arteries [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R 46742. CAS No. 76330-73-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121208. | |
| Ketanserin tartrate | Ketanserin (R41468) tartrate is a selective 5-HT2 receptor antagonist. Ketanserin tartrate also blocks hERG current ( I hERG ) in a concentration-dependent manner ( IC 50 =0.11 μM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: R41468 tartrate. CAS No. 83846-83-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10562A. | |
| Ketanserin tartrate | Ketanserin tartrate is the tartrate salt of ketanserin, which is a potent and selective serotonin (5-HT) receptor antagonist. It is selective for 5-HT2 with IC50 value of 6.3 nM and Ki value of 2.1 nM, but has no activity at 5-HT1 receptors. It is used in nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. It could prevent some diseases ranging from cancer to ischemic injury. It induces dose-dependent inhibition of contractile responses to 5-HT in isolated canine basilar, rat caudal artery, carotid, gastrosplenic arteries, coronary and so on. It reduces nicotine self-administration in rats, supporting an unexpected involvement of serotonin in nicotine addiction. It significantly decreases blood pressure variability (BPV) and hypertensive organ damage in spontaneously hypertensive rats. It may be used to treat hypertension in early-onset preeclampsia. Synonyms: Ketanserin tartrate; KJK-945; KJK945; KJK 945; R 49945; R49945; R-49945. 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione (2R,3R)-2,3-dihydroxybutanedioate; Ketanserin (+)-tartrate salt; 3-(2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1H,3H)-quinazolinedione (+)-tartrate salt; R 41468 (+)-tartrate salt; KJK 945; Ket; Perketan; R 49945; Serepress; Sufrexal. Grades: ≥97% by HPLC. CAS No. 83846-83-7. Molecular formula: C26H28FN3O9. Mole weight: 545.52. | |
| Ketanserin tartrate | Selective 5-HT2A serotonin receptor antagonist. ATP-sensitive potassium channel inhibitor. hERG potassium channel blocker. Group: Biochemicals. Alternative Names: 3--2,4(1H,3H)-quinazolinedione tartrate. Grades: Highly Purified. CAS No. 83846-83-7. Pack Sizes: 10mg, 50mg. Molecular Formula: C22H22FN3O3 C4H6O6. US Biological Life Sciences. | Worldwide |
| Ketanserin Tartrate (5-HT2A Serotonin Receptor Antagonist, Ketanserin, R 41 468) | A selective 5-HT2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT2AR (Ki = 1.49nM) relative to other family members like 5-HT2BR (Ki = 740nM) and 5-HT2CR (Ki = 59nM). Often used in conjunction with SB 206553 to distinguish 5-HT2AR and 5-HT2CR activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 83846-83-7. Pack Sizes: 50mg. Molecular Formula: C??H??FN?O?·C?H?O?. US Biological Life Sciences. | Worldwide |
| 2-PMDQ | 2-PMDQ, an analog of Ketanserin with beneficial hemodynamic effects in portal hypertensive rats, is a potent and selective α1-adrenoceptor antagonist. Synonyms: 2-[(4-Phenylpiperazin-1-yl)methyl]-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one; 2,3-Dihydro-2-[(4-phenyl-1-piperazinyl)methyl]imidazo[1,2-c]quinazolin-5(6H)-one; AT 112; AT112; AT-112. CAS No. 139047-55-5. Molecular formula: C21H23N5O. Mole weight: 361.45. | |
| 4F 4PP oxalate | 4F 4PP oxalate is a selective 5-HT2A antagonist with almost as high affinity (Ki = 5.3 nM) as ketanserin but with a much lower affinity for 5-HT2C sites (Ki = 620 nM). Synonyms: 4F 4PP oxalate; 4F4PP oxalate; 4F-4PP oxalate; 4-(4-Fluorobenzoyl)-1-(4-phenylbutyl)piperidine oxalate. Grades: ≥99% by HPLC. CAS No. 144734-36-1. Molecular formula: C22H26FNO.C2H2O4. Mole weight: 429.49. | |
| SB 206553 Hydrochloride (5-HT2C Serotonin Receptor Antagonist, SB 206553, 5-HT2B Serotonin Receptor Antagonist, SB 206553, SB206553, SB-206553) | A selective 5-HT2C serotonin receptor inhibitor with lesser affinity for 5-HT2BR. Often used in conjunction with ketanserin to distinguish 5-HT2AR and 5-HT2CR activity. SB206553 has highest affinity for 5-HT2CR (Ki = 3.2nM) and less for 5-HT2BR (Ki = 5.5nM) and 5-HT2AR (Ki = 2,300nM). Group: Biochemicals. Grades: Highly Purified. CAS No. 158942-04-2. Pack Sizes: 10mg. Molecular Formula: C??H??N?O·HCl. US Biological Life Sciences. | Worldwide |
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