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| Product | Description | |
|---|---|---|
| ketohexokinase | D-Sorbose, D-tagatose and 5-dehydro-D-fructose and a number of other ketoses and their analogues can also act as substrates. Group: Enzymes. Synonyms: ketohexokinase (phosphorylating). Enzyme Commission Number: EC 2.7.1.3. CAS No. 9030-50-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3060; ketohexokinase; EC 2.7.1.3; 9030-50-6; ketohexokinase (phosphorylating). Cat No: EXWM-3060. |  |
| Ketohexokinase Inhibitor (N8-(Cyclopropylmethyl)-N4-(2-(methylthio)phenyl)-2-(1-piperazinyl)-pyrimido[5,4-d]pyrimidine-4,8-diamine, KHK Inhibitor) | An orally bioavailable pyrimidinopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of human hepatic KHK activity (KHK-C isoform; IC50=12nM in a transcreener ADP assay) and efficiently blocks fructose-1-phosphate secretion (IC50 ≤ 400nM in HepG2 cells). Displays ~50-fold lower potency towards metabolic kinases, namely, ribokinase, hexokinase and adenosine kinase, and minimal binding affinities to diverse receptors and ion-channels, and excellent selectivity among a panel of 31-kinases including Akt1, AMPK, CaMKI/II, InsR, IRAK4, PKA and PKCtheta (IC50 >> 10uM). Shown to minimally affect the activities of human cytochrome p450 isozymes (1A2, 2C19, 2D6, 2C9 and 3A4), and exhibit high volume of distribution and high rate of clearance in rats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?S 2HCl. US Biological Life Sciences. |  Worldwide |
| KHK-IN-1 | KHK-IN-1, a pyrimidinopyrimidine derivative, is a ketohexokinase inhibitor that could have probable effect against diabetes and obesity by acting on Asp-27B in the ATP-binding region at some extent. Uses: Khk-in-1 is a ketohexokinase inhibitor that could have probable effect against diabetes and obesity by acting on asp-27b in the atp-binding region at some extent. Synonyms: KHK-IN-8; KHK IN 8; KHKIN8; KHK inhibitor 8; KHK-inhibitor-8; Ketohexokinase Inhibitor 8; ketohexokinase inhibitor. Grades: 98%. CAS No. 1303469-70-6. Molecular formula: C21H26N8S. Mole weight: 422.55. |  |
| KHK-IN-1 hydrochloride | The hydrochloride salt form of KHK-IN-1 which is a ketohexokinase inhibitor that could have probable effect against diabetes and obesity by acting on Asp-27B in the ATP-binding region at some extent. Uses: The hydrochloride salt form of khk-in-1 which is a ketohexokinase inhibitor that could have probable effect against diabetes and obesity by acting on asp-27b in the atp-binding region at some extent. Synonyms: MDK-0485; MDK0485; MDK 0485; ketohexokinase inhibitor. Grades: 98%. CAS No. 1303470-48-5. Molecular formula: C21H27ClN8S. Mole weight: 459.01. | |
| LY3522348 | KHK-IN-3 (Example 1) is a ketohexokinase ( KHK ) inhibitor. KHK-IN-3 can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KHK-IN-3. CAS No. 2568608-48-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149987. |  |
| PF-06835919 | PF-06835919, also known as MDK1846, is a potent ketohexokinase (KHK) inhibitor. PF-06835919 is reported in patent US 20170183328 A1, example 4. Increased fructose consumption and its subsequent metabolism have been implicated in hepatic steatosis, dyslipidemia, obesity, and insulin resistance in humans. Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, identification of a selective KHK inhibitor may help to further elucidate the effect of KHK inhibition on these metabolic disorders. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PF-06835919; PF 06835919; PF06835919; MDK1846; MDK-1846; MDK 1846; ketohexokinase inhibitor; ketohexokinase-In-1. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2102501-84-6. Molecular formula: C16H19F3N4O2. Mole weight: 356.35. Purity: >98%. IUPACName: 2-((1R,5S,6R)-3-(2-((S)-2-methylazetidin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)acetic acid. Canonical SMILES: O=C(C[C@@H]1[C@]2(CN(C[C@@]12[H])C3=NC(N4[C@H](CC4)C)=NC(C(F)(F)F)=C3)[H])O. Product ID: ACM2102501846. Alfa Chemistry ISO 9001:2015 Certified. Categories: Ketohexokinase inhibitor 1. |  |
| PF-06835919 | PF-06835919 (Ketohexokinase inhibitor 1) is an inhibitor of ketohexokinase (KHK) , with IC 50 s of 8.4 nM and 66 nM for KHK-C and KHK-A, respectively. PF-06835919 can be used for the study of metabolic disorders driven by the overconsumption of Fructose (HY-N0395) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ketohexokinase inhibitor 1. CAS No. 2102501-84-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00461. | |
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