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| Product | Description | |
|---|---|---|
| Ki16425 | Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with K i s of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA -induced activation of p42/p44 MAPK [1] [2]. Ki16425 can also inhibit LPA -induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Debio 0719. CAS No. 355025-24-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13285. |  |
| Ki16425 | Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively, shows no activity at LPA4, LPA5, LPA6. Synonyms: Ki16425; Ki-16425; Ki 16425. Grades: >98%. CAS No. 355025-24-0. Molecular formula: C23H23ClN2O5S. Mole weight: 474.96. |  |
| Ki16198 | Ki16198, the methyl ester of Ki16425, is a potent and orally active LPA receptor antagonist with Kis of 0.34 and 0.93 μM against inositol phosphate production induced by LPA1 and LPA3, respectively. It is effective for pancreatic cancer tumorigenesis and metastasis in vivo. Synonyms: 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonylamino)-3-methyl-5-isoxazolyl)benzylsulfanyl)propanoic acid methyl ester; Propanoic acid, 3-[[[4-[4-[[[1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]-, methyl ester; KI-16198; KI 16198; Methyl 3-((4-(4-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-3-methylisoxazol-5-yl)benzyl)thio)propanoate. Grades: >98%. CAS No. 355025-13-7. Molecular formula: C24H25ClN2O5S. Mole weight: 488.98. | |
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