Kinase Suppliers USA
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Product | Description | |
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Kinase Inhibitor Library Quick inquiry Where to buy Suppliers range | A unique collection of 2230 kinase inhibitors for high throughput screening and high content screening for drug discovery in kinase related diseases; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Targets include MAPK, PI3K, JAK, STAT, CDK, MEK, Insulin/IGF receptors, CaM Kinease II, PKA, JNK, PKC, RAF, EGFR, SAPK, GSK, MLCK, Src-family, IKK, PDGFR, VEGFR, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L1600. Categories: Kinase Inhibitor Libraries. | |
Kinase(phosphorylating), hexo- Quick inquiry Where to buy Suppliers range | Kinase(phosphorylating), hexo-. Group: Heterocyclic Organic Compound. CAS No. 9001-51-8. | |
Kinase(phosphorylating), protein serine/threonine Quick inquiry Where to buy Suppliers range | Kinase(phosphorylating), protein serine/threonine. Group: Heterocyclic Organic Compound. CAS No. 9026-43-1. Molecular formula: Ca. | |
MAP Kinase Kinase 3,6 (MKK3,6) (Ser189/207) BioAssay Phosphorylation Detection Kit, MAP Kinase Kinase 3,6 (MKK3,6) Nonphosphorylated Control Cell Extract Quick inquiry Where to buy Suppliers range | Nonphosphorylated Control Cell Extract for M2363-15A. Total cell extracts from NIH/3T3 cells, prepared without treatment, serve as a negative control. Group: Molecular Biology. Pack Sizes: 80ul. US Biological Life Sciences. | Worldwide |
MAP Kinase Kinase 3,6 (MKK3,6) (Ser189/207) BioAssay Phosphorylation Detection Kit, MAP Kinase Kinase 3,6 (MKK3,6) Phosphorylated Control Cell Extract Quick inquiry Where to buy Suppliers range | Phosphorylated Control Cell Extract for M2363-15A. Total cell extracts from NIH/3T3 cells, prepared with UV light treatment, serve as a positive control. Group: Molecular Biology. Pack Sizes: 80ul. US Biological Life Sciences. | Worldwide |
VEGFR2 Kinase Inhibitor VII, SKLB1002 (VEGFR Tyrosine Kinase Inhibitor XXXV, 6,7-Dimethoxy-4-(5-methyl-1,3,4-thiadiazol-2-ylthio)quinazoline, Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor VII) Quick inquiry Where to buy Suppliers range | A cell-permeable quinazoline that acts as a potent, ATP-binding site-targeting, VEGFR2-selective inhibitor (IC50=32nM), while exhibiting much reduced or little activity against 16 other kinases. An effective antiangiogenesis agent (98% inhibition of HUVEC tube formation at 10uM; 80% inhibition of zebrafish embryos intersegmental vessel growth at 2.5uM) that significantly suppresses SW620- and HepG2-derived tumor growth in mice (by 72% and 63%, respectively, in 18 days; 100mg/kg/day; i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Aurora 3, Control peptide (STK13, Serine Threonine Kinase 13, Aurora C, AIE2, AIK3, Aurora Related Kinase 3, Aurora/IPL1-like) Quick inquiry Where to buy Suppliers range | A synthetic peptide derived from the N-terminus of the human Aurora-3 protein. Group: Molecular Biology. Grades: Purified. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
Haspin Kinase Inhibitor, CHR-6494 (3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine, Haploid Germ Cell-Specific Nuclear Protein Kinase Inhibitor, CHR-6494, Indazolyl-propylimidazopyridazin-amine) Quick inquiry Where to buy Suppliers range | A cell-permeable indazolyl imidazopyridazinamine compound that acts as a potent and reversible inhibitor of histone kinase haspin activity (IC50 = 2nM) with moderate selectivity over TrkA, GSK-3beta, PIM1, Cdk1/B and Cdk2/A (% inhibition at 100nM = 58, 48, 36, 34 and 33, respectively) among a panel of 27-kinases. Shown to block pH3-Thr3, with no effect on pH3-Ser10 and pH3-Ser28, cause mitotic catastrophe, upregulate BUB1 and cyclin B1 levels, and potently induce apoptosis (IC50 = 473, 500 and 752nM in HeLa, HCT-116 and MDA-MB-231 cells, respectively). Further, efficiently blocks bFGF-induced sprouting vessel by 70% at 1uM (chicken embryo aortic arch ring assay) and suppresses tumor growth in HCT-116 xenografted mouse model (50mg/kg, i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
LRRK2 Inhibitor III, HG-10-102-01 (Leucine-Rich Repeat Kinase 2 Inhibitor III, Mixed-Lineage Kinase 1 Inhibitor I, MLK1 Inhibitor I, MNK Inhibitor III, (4- (5-Chloro-4- (methylamino)pyrimidin-2-ylamino)-3-methoxyphenyl) (morpholino)methanone) Quick inquiry Where to buy Suppliers range | A cell-permeable 2,4-diaminopyrimidinyl compound that acts as a potent, ATP-competitive LRRK2-selective inhibitor (IC5050 = 20.3, 3.2, 153.7 and 95.9nM, respectively,against human wt LRRK2 and G2019S, A2016T, G2019S/A2016T LRRK2 mutant; [ATP] = 100uM), displaying much reduced potency against MNK2 and MLK1 (IC50 = 0.6 and 2.1uM, respectively; [ATP] = 100uM) and little activity toward a panel of 136 other kinases. Although both HG-10-102-01 and LRRK2-In-1 inhibit cellular wt and G20195 LRRK2 phosphorylation (Optimal conc. 1 to 3uM), only HG-10-102-01 is effective against cellular A2016T and G2019S/A2016T LRRK2 phosphorylations (IC50 <3uM). And only HG-10-102-01, but not LRRK2-In-1 or CZC-25146, can cross blood-brain-barrier for LRRK2 phosphorylation inhibition in mice (30mg/kg to 50mg/kg i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O?. US Biological Life Sciences. | Worldwide |
MAP Kinase Kinase 3,6 (MKK3,6) Control Cell Extracts Quick inquiry Where to buy Suppliers range | MAP Kinase Kinase 3,6 (MKK3,6) Control Cell Extracts. Group: Biologicals. Grades: Lysate. Pack Sizes: 10Blots. US Biological Life Sciences. | Worldwide |
MAP Kinase Kinase 3,6 (MKK3,6) Nonphosphorylated Control Cell Extract Quick inquiry Where to buy Suppliers range | Nonphosphorylated Control Cell Extract for M2363-15A. Total cell extracts from NIH/3T3 cells, prepared without treatment, serve as a negative control. Group: Molecular Biology. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
MAP Kinase Kinase 3,6 (MKK3,6) Phosphorylated Control Cell Extract Quick inquiry Where to buy Suppliers range | MAP Kinase Kinase 3,6 (MKK3,6) Phosphorylated Control Cell Extract. Group: Molecular Biology. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
MAP Kinase Kinase 3,6 (MKK3,6) (Ser189/207) BioAssay Phosphorylation Detection Kit, Biotin (HRP) Quick inquiry Where to buy Suppliers range | MAP Kinase Kinase 3,6 (MKK3,6) (Ser189/207) BioAssay Phosphorylation Detection Kit, Biotin (HRP). Group: Molecular Biology. Grades: Affinity Purified. Pack Sizes: 100ul. US Biological Life Sciences. | Worldwide |
MAP Kinase p38, Control Cell Extracts (Mitogen Activated Protein Kinase p38, MAPK p38) Quick inquiry Where to buy Suppliers range | P38 MAP kinase (MAPK), also called RK (3) or CSBP (2), is the mammalian homologue of the yeast HOG kinase and participates in a signaling cascade controlling cellular responses to cytokines and stress (1-4). Four isoforms of p38 MAP kinase, alpha, beta, gamma and delta, have been identified so far. Like the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), UV light and growth factors (1-5). MKK3 and SEK activate p38 MAP kinase by phosphorylation at threonine 180 and tyrosine 182. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase 2 (3) and to phosphorylate the transcription factors ATF-2 (5), Max (6) and MEF2 (5-8). Nonphosphorylated p38 MAP Kinase Control Cell. Group: Biologicals. Alternative Names: EC=2.7.11.24. Grades: Lysate. Pack Sizes: 10Blots. US Biological Life Sciences. | Worldwide |
MARK/Par-1 Activity Inhibitor, 39621 (N-(2,5-Dimethylphenyl)-2-(4-(4-methoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-ylthio)acetamide, Microtubule Affinity Regulating Kinase Inhibitor, MAP Affinity Regulating Kinase Inhibitor, PAR1 Inhibitor) Quick inquiry Where to buy Suppliers range | A cell-permeable dihydropyrazinyl-thioacetamide that acts as an ATP-competitive MARK-selective inhibitor (IC50=3.6uM; [ATP]=100uM). Shown to effectively block primary rat cortical neuron axon growth (5.7um/hr vs 32.5um/hr with or without 20uM inhibitor) and prevent MARK2 overexpression-induced Tau Ser262 phosphorylation and cytotoxicity in CHO cells (10uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
MNK1/2 Inhibitor II, ETP-45835 (ETP45835?MNK Inhibitor II, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor II) (4-(3-(Piperidin-4-yl)-1H-pyrazol-5-yl)pyridine, diHCl) Quick inquiry Where to buy Suppliers range | A cell-permeable 3,5-disubstituted pyrazolo compound that acts as a selective MNK inhibitor (IC50=646 and 575nM, respectively, against MNK1 and MNK2) with much reduced or little activity against 24 other kinases (<15% inhibition at 5uM). Reported to exhibit good aqueous solubility (>100uM at pH 7.4) and inhibit the proliferation (IC50=17uM) and cellular eIF4E Ser209 phosphorylation (IC50=4.7uM) of MV4:11 cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N? 2HCl. US Biological Life Sciences. | Worldwide |
PKR Inhibitor III, 7DG (Double-stranded RNA-activated Protein Kinase Inhibitor III, EIF2AK2 Inhibitor III, 7-Desacetoxy-6,7-dehydrogedunin, Double-stranded RNA-dependent Protein Kinase Inhibitor III) Quick inquiry Where to buy Suppliers range | A cell-permeable gedunin analog that directly targets PKR via reversible interaction inhibits PKR-mediated cellular events by disrupting PKR signaling complexes assembly, such as IkK complex and inflammasome / pyroptosome, resulting in effective blockage of LPS-induced IkBbeta degradaion (20uM) and protection against anthrax toxin LT-induced caspase-1 activation as well as subsequent pyroptosis (10uM) in murine macrophage J774 cultures. PKR is also known to mediate LT-induced apoptosis via its kinase activity in LPS-primed Macrophages derived from C57BL/6 with a resistent NLRP1 allele, inhibitable by C16, but not by 7DG, while LT-induced pyroptosis in J774 cultures is insensitive to C16 treatment. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
Protein Kinase C, alpha, primers, amplimer 324bp (AAG6, MGC129900, MGC129901, PKCA, PKC-A, PKC-alpha, PRKACA, Protein kinase C alpha type), Primer A, Upstream Primer Quick inquiry Where to buy Suppliers range | Protein Kinase C, alpha, primers, amplimer 324bp (AAG6, MGC129900, MGC129901, PKCA, PKC-A, PKC-alpha, PRKACA, Protein kinase C alpha type), Primer A, Upstream Primer. Group: Molecular Biology. Pack Sizes: 1x50ul. US Biological Life Sciences. | Worldwide |
Protein Kinase C, alpha, primers, amplimer 324bp (AAG6, MGC129900, MGC129901, PKCA, PKC-A, PKC-alpha, PRKACA, Protein kinase C alpha type), Primer B, Downstream Primer Quick inquiry Where to buy Suppliers range | Protein Kinase C, alpha, primers, amplimer 324bp (AAG6, MGC129900, MGC129901, PKCA, PKC-A, PKC-alpha, PRKACA, Protein kinase C alpha type), Primer B, Downstream Primer. Group: Molecular Biology. Pack Sizes: 1x50ul. US Biological Life Sciences. | Worldwide |
SAPK1, JNK (Stress Activated Protein Kinase, Jun Kinase) Control Cell Extracts Quick inquiry Where to buy Suppliers range | The SAPK/JNK pathway is homologous to the MAPK pathway in its overall form but is activated by largely distinct stimuli (1). A variety of extracellular stimuli activate the JNK/SAPK pathway including inflammatory cytokines, UV light, inhibitors of protein synthesis and osmotic stress (1-5). Inflammatory cytokines such as TNFa and IL1 appear to activate this pathway via the Rac/Rho family of small GTP binding proteins, whereas inhibitors of protein synthesis and UV light appear to act independently of Rho and Rac (6). Activated MEKK1 phosphorylates SEK1 (also known as MKK4), which in turn activates SAPK (also known as JNK). SAPK binds tightly to the N-terminal region of c-Jun and ATF-2. It phosphorylates c-Jun at Ser63 and Ser73, and ATF-2 at Thr69 and Thr71 (5). Group: Biologicals. Grades: Lysate. Pack Sizes: 10Blots. US Biological Life Sciences. | Worldwide |
Sphingosine Kinase Inhibitor IV, CB5468139 (N-(3-chloro-1,4-dioxo-1,4-dihydro-2-naphthalenyl)-N-cyclohexylacetamide, SK Inhibitor IV, Sphingosine Kinase Inhibitor IV) Quick inquiry Where to buy Suppliers range | A cell-permeable naphthoquinone derivative that acts as an ATP-competitive inhibitior against sphingosine kinase 1 (IC50 = 2uM; [sphingosine] = 10uM & [ATP] = 100uM) and several protein kinases, including, but not limited to, TNK2, AURKB, Met, Syk, AURKC, Fyn, Flt2, PIM2, MST2, CLK1, Tie1, and Fak (IC50 <2uM), while exhibiting much reduced potency toward DAG Kinase and sphingosine kinase 2 (37% and no inhibition, respectively, at 100uM). Shown to be more potent than SK1/2 dual inhibitor against kidney adenocarcinoma A498 proliferation (GI50 = 10 and 20uM, respectively; 48h) and the two inhibitors are also reported to induce differential modulations of A498 cellular ceramides and S1P levels when applied at their respective GI50. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
SRPK Inhibitor, SRPIN340 (N- (2-Piperidin-1-yl-5- (trifluoromethyl) phenyl) isonicotinamide, Serine-Arginine-Rich Protein Kinase Inhibitor, SR Protein Kinase Inhibitor, SR Protein Phosphorylation Inhibitor 340, (SRPIN)340) Quick inquiry Where to buy Suppliers range | A cell-permeable isonicotinamide that acts as an ATP-competitive SRPK1-selective inhibitor (IC50 = 0.14 and 1.8uM, respectively, against mSRPK1 and mSRPK2) with much reduced activity against 143 other kinases. Shown to effectively counteract IGF-1-induced anti-angiogenic to pro-angiogenic VEGF isoforms switch both in cultures in vitro (1h 10uM SRPIN340 prior to 12h IGF-1 stimulation of PCIPs) and in a murine hypoxia-induced retinal neovascularization model in vivo (10pmol/uL/eye intraocular SRPIN340 injection) by inhibiting PKC/SRPK signaling-dependent, alternate splicing factor ASF- (SF2; splicing factor 2) mediated VEGF pro-mRNA PSS (proximal splice site) selection. Suppresses RNA virus Sindbis propagation (IC50 = 60uM in Vero cultures) and HCV-JFH1 replication (1 & 10uM SRPIN340 in Huh7.5.1 cultures). Exhibits no toxicity toward rats (2g/kg p.o. for 2 wks), CHO (5mg/ml for 24h), or Huh7 (30uM for 48h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Ack1 Inhibitor, AIM-100 (Activated Cdc42 Kinase 1 Inhibitor, (S)-5,6-Diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine) Quick inquiry Where to buy Suppliers range | A cell-permeable furopyrimidine that acts as a potent, ATP-binding site-targeting, Ack1-selective inhibitor (IC50 = 22nM) and effectively prevents receptor-mediated Ack1 activation (by >90% in MEF & LAPC4 cultures; 16h 800nM), while exhibiting much reduced potency against Lyn, Lck, Abl1 and BTK (IC50 ≥346.7nM) and no inhibitory activity toward 25 other kinases. Shown to completely inhibit EGF-induced, but not androgen DHT- (dihydrotestosterone) stimulated, AR transcription activity in serum- and androgen-deprived prostate cancer LAPC4 cutlures. Effectively inhibits androgen-independent LNCaP prostate cancer growth both in vitro (by 60%; 72h 8uM) and in castrated mice in vivo (4mg/kg/96h injections on day 7/11/15/19/23/27 post tumor transplant). Group: Biochemicals. Grades: Highly Purified. CAS No. 873305-35-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
A-kinase anchor protein 9 (1398-1407) Quick inquiry Where to buy Suppliers range | A-kinase anchor protein 9 (1398-1407) is amino acids 1398 to 1407 fragment of A-kinase anchor protein 9. AKAP-9 is a scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Synonyms: AKAP-9 (1398-1407). | |
A-kinase anchor protein 9 (1398-1407) Quick inquiry Where to buy Suppliers range | A-kinase anchor protein 9. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-086. | |
Akt1/2 kinase inhibitor Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG, 25MG. Mole weight: 551.64 (anhydrous free base basis). Catalog: IAR4241683. Assay: ≥98% (HPLC). | |
AKT Kinase Inhibitor Quick inquiry Where to buy Suppliers range | AKT Kinase Inhibitor is a Akt Kinase Inhibitor. Synonyms: 2-Propyn-1-ol, 3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-. Grades: >98%. CAS No. 842148-40-7. Molecular formula: C16H19N7O3. Mole weight: 357.37. | |
Annotated Phosphosites-Kinase Quick inquiry Where to buy Suppliers range | Annotated Phosphosites-Kinase. Uses: Enzyme Substrate Arrays. Product ID: PMA-H118. | |
ATR Kinase Inhibitor II (3-Amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfonyl)-phenyl)-N-phenylpyrazine-2-carboxamide) Quick inquiry Where to buy Suppliers range | A cell-permeable aminopyrazinyl-sulfone compound that acts as a potent, reversible and ATP-competitive inhibitor of ATR kinase (IC50 = 12nM; Ki=6nM) with excellent selectivity over ATM, DNA-PK (IC50 > 8uM) and in a 50-kinase panel (% inhibition at 2uM = 59, 57, 55, 52, 43 and 42 for AMPK, Lck, RIPK2, Ret, IKK-alpha and FGFR3, respectively). Shown to block pH2AX-Ser139 (IC50 = 420nM in hydroxyurea treated HT29 cells) and preferentially enhance cisplatin cytotoxicity against tumor cells over normal cells by ~7-fold at 620nM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
Aurora Kinase Inhibitor II Quick inquiry Where to buy Suppliers range | The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. Aurora kinase inhibitor II is a cell-permeable anilinoquinazoline that blocks the activity of Aurora A with IC50 of 0.39 μM. This compound has the ability to permeate the cell and is involved in the regulation of the cell cycle, particularly cell division. This compound has the ability to permeate the cell and is involved in the regulation of the cell cycle, particularly cell division. Synonyms: 4-(4?-Benzamidoanilino)-6,7-dimethoxyquinazoline. Grades: ≥98%. CAS No. 331770-21-9. Molecular formula: C23H20N4O3. Mole weight: 400.4. | |
Aurora Kinase Inhibitor III Quick inquiry Where to buy Suppliers range | Aurora kinase inhibitor III is a potent ATP-competitive aurora related kinase inhibitor with IC50 of 42 nM. Aurora kinase inhibitor III is a cell-permeable, 2,4-dianilinopyrimidine compound which has been used to study a variety of tumor types. It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively). Aurora kinase protein levels are elevated in c-myc-driven B-cell lymphomas in both mice and humans. Study of the inhibition of Aurora kinase proteins could lead to potential treatments for malignancies. Synonyms: Aurora Kinase Inhibitor III; AKI-7169; AKI 7169; AKI7169. Grades: ≥98%. CAS No. 879127-16-9. Molecular formula: C21H18F3N5O. Mole weight: 413.4. | |
Aurora Kinase Inhibitor VI, ZM447439 (4-(4-(N-Benzoylamino)anilino)-6- methoxy-7- (3- (1-morpholino) propoxy) quinazoline) Quick inquiry Where to buy Suppliers range | A cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC50=110 and 130nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC50=0.88, 1.03 and 1.79uM for Lck, Src and MEK1, respectively, and IC50>10uM for Cdk1/2/4, Plk1, Chk1). Blocks phosphorylation of Histone H3-Ser10 in Xenopus cycling egg extracts at 20uM, and reduces mitotic spindle assembly. Shown to repress kinetochore localization of BubR1, Cenp-E, and Mad2, and arrest the growth of proliferating tumor cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 331771-20-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
BMP Inhibitor III, LDN-212854 (Abl Inhibitor V, LDN212854, Bone Morphogenetic Protein Inhibitor III, PDGFR Tyrosine Kinase Inhibitor XXIV, RIP2 Inhibitor I, RIPK2 Inhibitor I, 5-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline) Quick inquiry Where to buy Suppliers range | A cell-permeable pyrazolopyrimidinyl quinoline that is superior to Dorsomorphin and DMH1 as an ATP-site-targeting, ALK1/2 inhibitor (IC50 = 2.40 and 1.30nM, respectively; [ATP] = 6uM) with respect to both potency and selectivity over ALK3/4/5 (IC50 = 0.858, 2.133, and 9.276uM, respectively). Also a potent RIPK2 inhibitor (IC50 = 6nM) with reduced potency against ABL1/c-abl, PDGFR-beta, ALK3, and PDGFR-alpha (IC50 = 40, 68, 85.8, and 650nM, respectively) and little inhibitory activity toward a panel of more than 190 kinases. Effectively inhibits ALK2- and ALK3-mediated C2C12 osteogenic differentiation (IC50 = 10 and 40.5nM, respectively) in vitro and prevents constitutively active ALK2 Q207D mutant-induced heterotopic ossification in mice (6mg/kg/12h via i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??N?. US Biological Life Sciences. | Worldwide |
Ca2+/Calmodulin Kinase II Inhibitor 281-309 Quick inquiry Where to buy Suppliers range | The Ca2+/Calmodulin Kinase II Inhibitor 281-309 controls the biological activity of Ca2+/Calmodulin Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 500μG. Mole weight: 3374.06. Catalog: IAR42415239. Assay: ≥97% (HPLC). | |
Calmodulin-Dependent Protein Kinase II 281-309 Quick inquiry Where to buy Suppliers range | Calmodulin-Dependent Protein Kinase II (281-309) is a peptide of calcium/calmodulin-dependent protein kinase II (CaM-kinase II). Uses: Peptide Inhibitors. CAS No. 116826-37-0. Product ID: R1267. | |
Calmodulin-Dependent Protein Kinase II 290-309 Quick inquiry Where to buy Suppliers range | Calmodulin-dependent protein kinase II (290-309) is a synthetic peptide derived from the rat brain protein sequence that contains the calmodulin binding domain. It inhibits calcium/calmodulin-dependent protein kinase II (CaMKII) with IC50 of 52 nM and CaMKII-dependent phosphodiesterase activity with IC50 of 1.1 nM. It has been used in the study of CaM binding, autophosphorylatio and dynamics. Synonyms: Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala; L-leucyl-L-lysyl-L-lysyl-L-phenylalanyl-L-asparagyl-L-alanyl-L-arginyl-L-arginyl-L-lysyl-L-leucyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-leucyl-L-threonyl-L-threonyl-L-methionyl-L-leucyl-L-alanine; CaM kinase II (290-309); Calmodulin-dependent Protein Kinase II fragment 290-309. Grades: ≥97% by HPLC. CAS No. 115044-69-4. Molecular formula: C103H185N31O24S. Mole weight: 2273.83. | |
Calmodulin-Dependent Protein Kinase II 290-309 Quick inquiry Where to buy Suppliers range | Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. Uses: Peptide Inhibitors. CAS No. 115044-69-4. Product ID: R1268. | |
Calmodulin-Dependent Protein Kinase II (290-309) trifluoroacetate salt Quick inquiry Where to buy Suppliers range | Calmodulin-dependent protein kinase II (290-309) is a synthetic peptide derived from the rat brain protein sequence that contains the calmodulin binding domain. It inhibits calcium/calmodulin-dependent protein kinase II (CaMKII) with an IC50 value of 52 nM and CaMKII-dependent phosphodiesterase activity with IC50 of 1.1 nM. Calmodulin-dependent protein kinase II (290-309) has been used in the study of CaM binding, autophosphorylation, and dynamics. Grades: ≥95%. Molecular formula: C103H185N31O24S·xCF3COOH. Mole weight: 2273.83. | |
Calmodulin-dependent Protein Kinase II fragment 290-309 Quick inquiry Where to buy Suppliers range | ≥97% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 115044-69-4. Pack Sizes: 1MG. Mole weight: 2273.83. Catalog: AP115044694-B. Assay: ≥97% (HPLC). | |
Calmodulin Kinase IINtide Quick inquiry Where to buy Suppliers range | A potent and specific inhibitor of CaMK II (IC50 = 50 nM for both the total and Ca2+-independent CaMK II activity). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 3115.63. Catalog: IAR42415241. Assay: ≥95% (HPLC). | |
Calmodulin Kinase IINtide, Myristoylated Quick inquiry Where to buy Suppliers range | The myristoylated form of CaMK IINtide. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 4698.21. Catalog: IAR42415242. Assay: ≥95% (HPLC). | |
CaMKII Inhibitor XII (Ca2+/Calmodulin-Dependent Protein Kinase II Inhibitor XII) Quick inquiry Where to buy Suppliers range | A pyrimidinyl sulfonamide compound that acts as a potent, reversible and CaM non-competitive inhibitor of CaMKII activities (IC50 = 0.063uM) with excellent selectivity over several kinases (IC50 = >60, 36, 11, 30 and 21uM for CaMKIV, MLCK, p38alpha, Akt1 and PKC, respectively). Shown to exhibit ~25-fold greater potency towards CaMKII than the CaM-competitive inhibitor KN-93. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
CARBAMATE KINASE Quick inquiry Where to buy Suppliers range | CARBAMATE KINASE. Group: Heterocyclic Organic Compound. Grades: 96%. CAS No. 9026-69-1. | |
Casein from milk, suitable for substrate for protein kinase (after dephosphorylation) Quick inquiry Where to buy Suppliers range | In milk, casein exists as a calcium salt, forming micellar particles surrounded by soluble kappa-casein. The casein component of milk is relatively thermally stable and can withstand temperatures of 62-71°C, while the whey protein component denatures at this temperature. Casein is digested slowly in organisms and coagulates in the stomach, resulting in anti-catabolic properties of casein. Casein is a large, firm, dense curd that is extremely difficult to digest. There are four different types of casein, each with a different genetic variation. They are α-s1 casein, α-s2 casein, β-casein and κ-casein, respectively. Uses: ·Nutritional supplements ·Raw material of food ·Paint, wood glue, plastic fiber ·Dentist Materials. Group: Animal Hydrocolloids. CAS No. 9000-71-9. Molecular Weight: 2061.96 g/mol. Boiling Point: 280 °C (dec.) (lit.). Flash Point: ≥70 %. Purity: 1.26 g/cm3. Density: H2O: insoluble, forms a cloudy suspension. | |
Casein Kinase II Inhibitor VIII Quick inquiry Where to buy Suppliers range | The Casein Kinase II Inhibitor VIII controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 10MG. Mole weight: 354.38. Catalog: IAR42415282. Assay: ≥99% (HPLC). | |
Casein Kinase II Inhibitor VIII (4- (2- (4-Methoxybenzamido) thiazol-5-yl) benzoic acid, CK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII) Quick inquiry Where to buy Suppliers range | A cell-permeable thiazolamide compound that acts as a potent, reversible, and ATP-competitive inhibitor against casein kinase-2/CK2 (IC50=32 and 46nM against CK2a and CK2a', respectively), as well as DYRK1B and FLt-3 (82% and 76% inhibition, respectively, at 30nM), while diplaying reduced or little potency toward other targets in a 70-kinase panel selectivity profile study. Shown to effectively block the proliferation of a variety of cancer cells (IC50=2.6, 1.6, and 2.4uM, in A549, HCT116, and MCF-7 cultures, respectively). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Casein Kinase II Inhibitor XII, TBBz (4, 5, 6, 7-Tetra bromobenzimidazole, CYP24A1 inhibitor, TBBz, CK2 Inhibitor, TBBz) Quick inquiry Where to buy Suppliers range | A cell-permeable halogenated benzimidazole compound that acts as a selective and ATP competitive inhibitor of casein kinase II (CK2, Ki = 70nM for the active hetero-tetrameric form). However, its effect on free CK2a and CK2a' subunits is significantly reduced (Ki = 510 and 400nM, respectively). Reported to reduce viability and proliferation in HeLa, Jurkat, and HL-60 cells (at 25uM). Also shown to disrupt the promoter activity of CYP24A1 and down-regulates its endogenous and 1, 25-Vitamin D3 (1,25-D3)-induced expression in PC3 cells. Synergistically enhances the anti-tumor effect of 1, 25-D3 in a PC3 xenograft murine model. CAS No:577779-57-8. Group: Biochemicals. Grades: Highly Purified. CAS No. 577779-57-8. Pack Sizes: 20mg. Molecular Formula: C?H?Br?N?, Primary Target: CK2. US Biological Life Sciences. | Worldwide |
Casein Kinase I Inhibitor III, PF-4800567 Quick inquiry Where to buy Suppliers range | The Casein Kinase I Inhibitor III, PF-4800567 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG. Mole weight: 359.81. Catalog: IAR42415280. Assay: ≥99% (HPLC). | |
Casein Kinase I Inhibitor III, PF-4800567 (CKI Inhibitor III, PF-4800567)(3-(3-Chlorophenoxymethyl)-1-(tetrahydropyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine, HCl) Quick inquiry Where to buy Suppliers range | A cell-permeable pyrazolopyrimidinyl amino compound that acts as a potent, ATP-competitive and reversible inhibitor of CKle with ~22-fold greater potency over CKld (IC50=32 and 711nM, respectively) and displays excellent selectivity among 50-kinases, with the only exception of EGFR (69% inhibition at 1uM). Shown to preferentially block PER3 (PERIOD3) nuclear translocation in COS7-GFP-PER3-CKle cells over CKld-transfected cells (IC50=0.13 and 2.65uM, respectively), and PER2 degradation in COS7-GFP-PER2-CKle cells. Unlike Casein Kinase I Inhibitor II, PF-670462, PF-4800567 exerts only marginal effect on circadian clock under similar conditions. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Casein Kinase I Inhibitor V, LH846 - CAS 639052-78-2 Quick inquiry Where to buy Suppliers range | The Casein Kinase I Inhibitor V, LH846 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 10MG. Mole weight: 316.81. Catalog: IAR42415281. Assay: ≥98% (HPLC). | |
Casein Kinase I Inhibitor V, LH846 (N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide)(N-(5-Chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetamide) Quick inquiry Where to buy Suppliers range | A cell-permeable benzothiazolo compound that acts a potent, selective, and reversible inhibitor of CKIg (IC50=290nM). Exhibits much reduced potency towards CKle and CKla isoforms (IC50=1.3 and 2.5uM, respectively). Does not affect the activity of CK2 or other kinases in a 59-protein kinase panel. Shown to block CKld-dependent period protein PER1 phosphorylation and diminish its proteasomal degradation in a dose-dependent manner. Also, shown to lengthen the circadian period in U2OS cells (10h at 8uM) without significantly affecting the amplitude of Per2-dLuc and Bmal1-dLuc rhythms. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Casein kinase I isoform alpha (26-34) Quick inquiry Where to buy Suppliers range | Casein kinase I isoform alpha. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-198. | |
Casein Kinase Substrates 3 Quick inquiry Where to buy Suppliers range | Casein Kinase Substrates 3 is a substrate of casein kinase. Synonyms: Arg-Arg-Lys-Asp-Leu-His-Asp-Asp-Glu-Glu-Asp-Glu-Ala-Met-Ser-Ile-Thr-Ala; L-arginyl-L-arginyl-L-lysyl-L-alpha-aspartyl-L-leucyl-L-histidyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alanyl-L-methionyl-L-seryl-L-isoleucyl-L-threonyl-L-alanine; Casein Kinase I substrate. Grades: ≥95% by HPLC. CAS No. 154444-97-0. Molecular formula: C85H139N27O35S. Mole weight: 2131.24. | |
Casein Kinase Substrates 3 Quick inquiry Where to buy Suppliers range | Casein Kinase Substrates 3 is a substrate of casein kinase. Uses: Peptide Inhibitors. CAS No. 154444-97-0. Product ID: R1271. | |
Cdc2-Like Kinase Inhibitor IV, KH-CB19 Quick inquiry Where to buy Suppliers range | The Cdc2-Like Kinase Inhibitor IV, KH-CB19 controls the biological activity of Cdc2-Like KInase. This small molecule/inhibitor is primarily used for Cell Structure applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 10MG. Mole weight: 338.19. Catalog: IAR42417807. Assay: ≥95% (HPLC). | |
Cdc2-Like Kinase Inhibitor IV, KH-CB19 ((E)-Ethyl-3-(2-amino-1-cyanovinyl)-6,7-dichloro-1-methyl-1H-indole-2-carboxylate) Quick inquiry Where to buy Suppliers range | A cell-permeable N-methylindolyl-enaminonitrile compound that acts as a potent, non-ATP mimetic binding and reversible inhibitor of Clk1 and Dyk1A (IC50=19.7 and 55.2nM, respectively) with moderate to excellent selectivity over Clk3 (IC50=530nM) and against 71-kinases. Shown to suppress phosphorylation of Ser/Arg-rich (SR) proteins, regulate alternative splicing and lower both full-length and alternatively spliced human tissue factor isoforms much more efficiently than Cdc2-Like Kinase Inhibitor, TG003 in HMEC-1 cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??Cl?N?O?, Molecular Weight: 338.2. US Biological Life Sciences. | Worldwide |
Ceramide kinase inhibitor,k1 Quick inquiry Where to buy Suppliers range | White solid. Group: Heterocyclic Organic Compound. Grades: 96%. CAS No. 1258005-85-4. Molecular formula: C21H28O4. Mole weight: 344.4. | |
cGMP Dependent Kinase Inhibitor Peptide Quick inquiry Where to buy Suppliers range | cGMP Dependent Kinase Inhibitor Peptide. Group: Biochemicals. Grades: Purified. CAS No. 82801-73-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
cGMP Dependent Kinase Inhibitor Peptide Quick inquiry Where to buy Suppliers range | cGMP Dependent Kinase Inhibitor Peptide. Uses: Peptide Inhibitors. CAS No. 82801-73-8. Product ID: R0846. | |
cGMP Dependent Kinase Inhibitor Peptide Quick inquiry Where to buy Suppliers range | PKG Inhibitor is a competitive inhibitor of cGMP-dependent protein kinase (PKG). It is an analog of a substrate peptide corresponding to a phosphorylation site of histone H2B, and inhibits phosphorylation of intact histones by PKA. Synonyms: cGMP Dependent Kinase Inhibitor Peptide. Grades: >98%. CAS No. 82801-73-8. Molecular formula: C38H74N18O10. Mole weight: 943.12. | |
Choline Kinase-a Inhibitor, CK37 (CK37, N-(3,5-dimethyl-dimethylphenyl)-2-[[5-(4-ethylphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide) Quick inquiry Where to buy Suppliers range | A cell-permeable, non-Hemicholinium-3 derivative and choline-competitive choline kinase-a inhibitor. It is demonstrated to inhibit endogenous choline kinase activity, dose-dependently, between 1-10uM, and dose-dependently decrease phosphocholine concentrations, as well as levels of downstream choline metabolites, including phosphatidylcholine and phosphatidic acid in HeLa cells. At 10uM, it is also shown to attenuate MAPK and PI3K/AKT signaling, and disrupt the actin cytoskeleton and membrane ruffling, consistent with siRNA choline kinase-a transfection. This compound exhibits dose-dependent suppression of cell growth in six tumor cell lines (IC50=5-10uM), in vitro. Furthermore, it is shown to suppress tumor growth in a mouse model by 48% at 0.08mg/g daily dose for 8 days without obvious toxicity, in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 1001478-90-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
CID 2011756 (Pan Protein Kinase D (PKD) Inhibitor, Cell Permeable, 5- (3-Chlorophenyl) -N-[4- (4-morpholinylmethyl) phenyl]-2-furancarboxamide) Quick inquiry Where to buy Suppliers range | Protein kinase D (PKD) inhibitor (IC50 values are 0.6, 0.7 and 3.2um for PKD2, PKD3 and PKD1 respectively). Cell permeable (EC50=10um for PKD1 inhibition). ATP-competitive. Group: Biochemicals. Grades: Highly Purified. CAS No. 638156-11-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
C-Jun-amino-terminal kinase-interacting protein 2 (683-692) Quick inquiry Where to buy Suppliers range | C-Jun-amino-terminal kinase-interacting protein 2. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-068. | |
c-Met Kinase Inhibitor III Quick inquiry Where to buy Suppliers range | The c-Met Kinase Inhibitor III controls the biological activity of c-Met. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 2MG. Mole weight: 419.28. Catalog: IAR42415667. Assay: ≥95% (HPLC). | |
Compound 43 TAO Kinase Inhibitor Quick inquiry Where to buy Suppliers range | Compound 43 TAO kinase inhibitor is an ATP-competitive and selective inhibitor of TAOK1 and TAOK2 (IC50s = 11 and 15 nM, respectively). It is selective for TAOK1 and TAOK2 over 62 kinases in a panel, but does inhibit TAOK3 by 87% and seven additional kinases by 21-52%. Synonyms: N-[2-oxo-2-[(1,2,3,4-tetrahydro-1-naphthalenyl)amino]ethyl]-[1,1'-biphenyl]-4-carboxamide. Grades: ≥98%. CAS No. 850467-66-2. Molecular formula: C25H24N2O2. Mole weight: 384.47. | |
Creatine kinase (from Rabbit muscle) Quick inquiry Where to buy Suppliers range | Creatine kinase (from Rabbit muscle). Group: Heterocyclic Organic Compound. Alternative Names: CK, ATP: creatine N-phosphotransferase. Grades: 96%. CAS No. 9026-66-8. Mole weight: 1.0079. | |
Cyclin-dependent kinase 4 (924-932) Quick inquiry Where to buy Suppliers range | Cyclin-dependent kinase 4. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-194. | |
DNA-dependent protein kinase catalytic subunit (2836-2844) Quick inquiry Where to buy Suppliers range | DNA-dependent protein kinase catalytic subunit. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-075. | |
eEF2K Inhibitor, A-484954 (7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic Elongation Factor-2 Kinase Inhibitor, A-484954) Quick inquiry Where to buy Suppliers range | A cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50=280nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.CAS No.142557-61-7. Group: Biochemicals. Grades: Highly Purified. CAS No. 142557-61-7. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Molecular Weight: 289.3. US Biological Life Sciences. | Worldwide |
eIF2-GTP-tRNAiMet Ternary Complex Inhibitor, BTdCPU (N,N'-diarylurea;translation Initiation Tenrary Complex Inhibitor, 1-(benzo[d][1, 2, 3]thiadiazol-6-yl)-3-(3, 4-dichlorophenyl)urea, BTdCPU, Heme-regulated Inhibitor Kinase Activator, BTdCPU) Quick inquiry Where to buy Suppliers range | A cell-permeable N,N'-diarylurea that acts as an inhibitor of the formation of the ternary complex of eukaryotic translation initiation factor 2 (eIF2), GTP and the initiator methionine tRNA (Met-tRNAi), a key regulatory step of translation initiation. It directly activates heme-regulated inhibitor kinase (HRI), which then phosphorylates eIF2a in cells at 10uM and in cell-free extracts dose-dependently, and thereby prevents respective ternary complex formation without elevating oxidative stress. The sensitivities of various cancer cell lines to the anti-proliferative effects of this compound are shown to correlate with the expression of HRI. Furthermore, this compound displays tumor growth inhibition in a mice xenograft model of MCF-7 human breast cancer cells at 175mg/kg, in vivo.CAS No:1257423-87-2. Group: Biochemicals. Grades: Highly Purified. CAS No. 1257423-87-2. Pack Sizes: 10mg. Molecular Formula: C??H?Cl?N?OS, Molecular Weight: 339.2. US Biological Life Sciences. | Worldwide |