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| Product | Description | |
|---|---|---|
| KN-93 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| KN-93 | KN-93. Group: Biochemicals. Alternative Names: N- [2- [ [ [3- (4-Chlorophenyl) -2-propen-1-yl] methylamino] methyl] phenyl] -N- (2-hydroxyethyl) -4-methoxy Benzene sulfonamide. Grades: Highly Purified. CAS No. 139298-40-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C26H29ClN2O4S. US Biological Life Sciences. |  Worldwide |
| KN-93 | KN-93 is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II ( CaMKII ) with a K i of 370 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 139298-40-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15465. |  |
| KN-93 | KN-93 is a selective Ca2+/calmodulin-dependent protein kinase II inhibitor, which has been implicated in the regulation of smooth muscle contractility. CaM kinase II activation was inhibited by KN-93 pretreatment (IC50 ~1 μM). KN-93 inhibited histamine-induced tonic force maintenance, whereas early force development and MLC20 phosphorylation responses during the entire time course were unaffected. Both force development and maintenance in response to KCl were inhibited by KN-93. Rapid increases in KCl-induced MLC20 phosphorylation were also inhibited by KN-93, whereas steady-state MLC20 phosphorylation responses were unaffected. In contrast, phorbol 12,13-dibutyrate (PDBu) did not activate CaM kinase II and PDBu-stimulated force development was unaffected by KN-93. Thus KN-93 appears to target a step(s) essential for force maintenance in response to physiological stimuli, suggesting a role for CaM kinase II in regulating tonic contractile responses in arterial smooth muscle. Pharmacological activation of protein kinase C bypasses the KN-93 sensitive step. Uses: Protein kinase inhibitors. Synonyms: KN 93; KN93. Grades: >98%. CAS No. 139298-40-1. Molecular formula: C26H29ClN2O4S. Mole weight: 501.04. |  |
| KN-93 - CAS 139298-40-1 | A cell-permeable, reversible and competitive inhibitor of rat brain CaM kinase II (Ki = 370 nM). Group: Fluorescence/luminescence spectroscopy. | |
| KN-93 hydrochloride | KN-93 hydrochloride is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II ( CaMKII ) with a K i of 370 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1956426-56-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15465A. | |
| KN-93 hydrochloride | KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII), a multifunctional serine/threonine protein kinase that transmits calcium signals in various cellular processes. KN-93 is commonly used for determining cellular functions. Synonyms: KN-93 HCl; N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide hydrochloride. Grades: ≥98%. CAS No. 1956426-56-4. Molecular formula: C26H29ClN2O4S·HCl. Mole weight: 537.5. | |
| KN-93 phosphate | KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II , with K i of 370 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1913269-12-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-15465B. | |
| KN-93 Phosphate | KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities. Synonyms: (E)-N- (2- ( ( (3- (4-chlorophenyl)allyl) (methyl)amino)methyl)phenyl)-N- (2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate; KN93; KN 93; KN-93; KN-93 phosphate. Grades: >98%. CAS No. 1188890-41-6. Molecular formula: C26H32ClN2O8PS. Mole weight: 599.03. | |
| KN-93 (Water Soluble) | Selective Ca2+/calmodulin-dependent protein kinase II inhibitor. Insulin release inhibitor. Acid secretion inhibitor. G1 cell cycle arrest inducer. Apoptosis inducer. Ion channel inhibitor. ROS inducer. Androgen receptor inhibitor. Group: Biochemicals. Alternative Names: 2-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine. Grades: Highly Purified. CAS No. 139298-40-1. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C26H29ClN2O4S H3PO4. US Biological Life Sciences. | Worldwide |
| KN-93, Water-Soluble | This KN-93 is a water-soluble version of KN-93 that acts as a reversible and competitive inhibitor of CaM kinase II (Ki = 370 nM for rat brain). Group: Fluorescence/luminescence spectroscopy. | |
| CaMKII Inhibitor XII (Ca2+/Calmodulin-Dependent Protein Kinase II Inhibitor XII) | A pyrimidinyl sulfonamide compound that acts as a potent, reversible and CaM non-competitive inhibitor of CaMKII activities (IC50 = 0.063uM) with excellent selectivity over several kinases (IC50 = >60, 36, 11, 30 and 21uM for CaMKIV, MLCK, p38alpha, Akt1 and PKC, respectively). Shown to exhibit ~25-fold greater potency towards CaMKII than the CaM-competitive inhibitor KN-93. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| KN-92 | KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell. Synonyms: KN 92; KN92. Grades: >98%. CAS No. 176708-42-2. Molecular formula: C24H25ClN2O3S. Mole weight: 456.98. | |
| KN-92 - CAS 1135280-28-2 | KN-92, CAS 1135280-28-2, is useful as a negative control for KN-93 (Cat. No. 422708), a Ca2+/CaM Kinase II inhibitor. Group: Fluorescence/luminescence spectroscopy. | |
| KN-92 hydrochloride | KN-92 is an inactive derivative of KN-93, the selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII). At concentrations up to 25 μM, KN-92 is ineffective at inhibiting CaMKII or arresting cell growth of NIH 3T3 fibroblasts. It is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. Synonyms: KN 92 hydrochloride; KN92 hydrochloride. Grades: >98%. CAS No. 1431698-47-3. Molecular formula: C24H26Cl2N2O3S. Mole weight: 493.45. | |
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